To further strengthen its activities in the detection of single uranium particles, the JRC and Euratom Safeguards have decided to jointly establish a high-sensitivity particle analysis laboratory. The new laboratory’s core facility will be a large geometry secondary ion mass spectrometer (LG-SIMS) for trace analysis of aerosol particles. It will allow the detection speed and sensitivity of nuclear material to be increased by at least a factor of ten. The minor isotopes of uranium will become accessible, which is important for identifying the source of the material.