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Joslin Identifies Source of Beta Cell Damage Scientists at the Joslin Diabetes Center, Boston, MA, led by Principal Investigator Robert Stanton, M.D., have discovered that high blood glucose levels damage a key enzyme that guards insulin-producing beta cells. Their surprising finding raises hopes of finding drugs that protect the enzyme, and thus the beta cells and their insulin production. The discovery focuses on a cellular process known as "oxidative stress." |
Joslin Diabetes Center Release Here. No specific data given, but Jenny Ruhl, over at Blood Sugar 101, cites to an Italian study that indicated impaired beta cell functioning in folks with two-hour OGTTs over 100:
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In lean NGTs with a 2-h plasma glucose concentration (2-h PG) between 5.6 and 6.6 and between 6.7 and 7.7 mmol/l, there was a progressive decline in I/G÷IR compared with NGTs with a 2-h PG less than 5.6 mmol/l. |