Alley comes from San Francisco designers and partners Laura Patnaude and John Robblee. They consider their garments to be stylish clothes tailored for the athletically fit male. For this Spring/Summer 2010 Alley has put together a collection of stylish button down tops, jackets, shorts, and slacks. Available now at Alley.
Continue reading for more images.
When a North Korean Submarine shot a torpedo that hit a south Korean ship and sunk 46 people. The South Korean President, Lee Myung-bak suspended all trade with North Korea for the attack. North Korea now has taken it’s own action by severing all links, escalating the standoff over accusations that the North sank a South Korean’s Ship.
North Koreans news agency also reported that North Korea would expel all South Koreans from a joint-industrial zone in Kaesong, near the border.
This also sparked the tension between the two separated countries, and just time will tell what can happen. The U.S also started to get ready for war as the tension grows. Barack Obama has also said that the U.S is in the favor of the South Koreans and has their full support and that they should start getting ready for a future battle. Pyongyang has denied any relation to the march incident and said that the South Korean President was listening to a report by an International team. This sparks strong vigilance and alert for both countries.
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If you’re at ASM, I just want to let you know I’ll be at the ASM Press Bookstore from 1 pm to 2 pm on Wednesday. The bookstore is on the far right end of the lobby as you’re standing in front of the convention center. If you want to talk about the things I’ll be discussing this afternoon at 5:30 pm, come by. Also, ASM Press has signed copies of Microcosm for sale. See you there!
Luke Timmerman wrote:
Vertex Pharmaceuticals has finally got the definitive proof it needs to say it has made a breakthrough for hepatitis C patients. The Cambridge, MA-based biotech company said today that its experimental drug for the chronic liver damaging disease was able to cure three-fourths of patients in the last stage of clinical testing required for FDA approval.
Vertex’s telaprevir compound, when given in combination with two standard drugs, was able to eradicate any detectable sign of the hepatitis C virus in the blood for 75 percent of patients a full 24 weeks after they completed their course of therapy, Vertex said today in a statement. That is compared with 44 percent who did that well on a typical 48-week course of the usual drugs, pegylated interferon alpha and ribavirin. The results, which essentially represent the rate of clinical cures, were from a pivotal study of 1,095 patients known as “Advance.”
This is the first time a company has shown in the final phase of clinical testing that a protease inhibitor, a type of enzyme blocker on the virus, which can almost double the cure rate for hepatitis C patients, while cutting the course of treatment in half for the standard drugs, which cause flu-like symptoms. An estimated 170 million people worldwide, and about 3 million people in the U.S. are infected with chronic hepatitis C, which damages the liver and can shorten lifespans. If Vertex can confirm these results in two more pivotal trials that are expected to yield results in coming months, Vertex could seek FDA approval later this year and bring telaprevir to the U.S. market in 2011. U.S. sales alone could amount to more than $2 billion after a couple years, analysts say.
“These first Phase 3 results are important for people with hepatitis C, as they represent a potential new era of therapy where doctors may be able to use direct acting antiviral medicines to improve treatment and help patients potentially avoid life-threatening liver-related consequences,” said Ira Jacobson, the chief of gastroenterology and hepatology, at Weill-Cornell Medical College, in a Vertex statement.
Shares of Vertex (NASDAQ: VRTX) climbed 11 percent to $38 in after-hours trading today following the announcement.
The data to support telaprevir shouldn’t come as a surprise given what the company has seen in its previous studies. This Advance trial enrolled patients who have chronic hepatitis C infections, but have never before been treated. That’s because many people consider the standard therapy—pegylated interferon alpha and ribavirin—as worse than the disease because of the flu-like symptoms they must endure for almost a year.
Doctors wanted to see in this study whether adding telaprevir, as a pill taken three times a day, would be able to provide enough benefit to outweigh the side effects. Patients were randomly …Next Page »
The paper reviewed is ‘Behavioral Symptoms and Caregiver Burden in Dementia’ by Shaji and colleagues and freely available here.
Aims: The authors write that
‘The present study examines the prevalence of BPSD in a community sample of patients with dementia and its impact on the caregivers‘
Method: The study took place in a rural area in Kerala, India. Trained healthworkers identified cases which were then screened by clinicians using DSM-IV criteria and the Clinical Dementia Rating (CDR) scale. Subjects rated as moderate to severe on the CDR were included in the study. I didn’t notice any exclusion criteria and the population might therefore be representative of a clinical population (albeit with selection bias influencing the sample population characteristics). The subjects were also included in two other studies and three outcome measures were collected
The statistical tests used for different data types are clearly stated.
Results:
Discussion:
The authors draw a number of conclusions. They note the absence of a relationship between BEHAVE-AD and GHQ-12 scores and suggest that a larger sample size may be helpful in exploring this relationship further.
Conclusions:
I thought this was a small but interesting study in a sample with family based care of people with moderate to severe dementia. There was found to be an association between GHQ scores in carers and ZBI scores although the direction of the link was unclear given the cross-sectional design of this study.
Call for Authors: If you are interested in writing an article or series of articles for this blog please write to the e-mail address below. Copyright can be retained. Index: An index of the site can be found here. The page contains links to all of the articles in the blog in chronological order. Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail [email protected]. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.
The HTC Incredible vanished from Verizon’s website on Tuesday — for a grand total of about 6 minutes. Don’t worry, it’s not in the midst of some massive recall or anything. It apparently was just to swap out some of the specs — mainly the addition of a 2GB microSD card, says Mobile Burn. (Though we don’t see that mentioned.) That said, the estimated shipping date is June 15, so you might want to trek to your nearest brick-and-mortar store if you’re looking for one. [Mobile Burn via VZW]
Update: Verizon just got back with us, and indeed the down time was nothing more nefarious than to update the microSD card spec. Sky’s not falling.
This is a post by Android Central. It is sponsored by the Android Central Accessories Store
Parece que a los australianos le gustan los coches italianos, puesto que volvemos con un nuevo coche de policía, ahora ha sido el Alfa Romeo Mi.To el que servirá a las fuerzas del orden en Sydney.
Me hubiera gustado verlo con sirenas, pero el fin para el que va destinado este Mi.To no debe de necesitarlas, puesto que será el coche reclamo para una campaña de seguridad vial destinada a la gente joven, de la que quieren captar la atención con el italiano vestido de policía.
Además esta colaboración de la firma italiana y las autoridades policiales de Sydney no es nueva, puesto que hace cuatro años también se cedió un GT para actividades divulgativas y de seguridad vial.
Vía | Autoblog.it
LaCie’s new Rugged Safe HDD is for the super-paranoid: it offers 128-bit AES hardware encryption, biometric fingerprint access and a shock-proof enclosure. Your high school papers and pirated SNES ROMs will be downright untouchable. More »
LaCie – Security – Cryptography – Universal Serial Bus – Hard disk drive
No one dreams of leaving a lasting carbon footprint on the world when they depart. But if it’s a choice between that and being reduced to a brown soupy liquid and a pile of bones, which option would you take? The California legislature is considering allowing funeral homes to provide a third alternative to burial or cremation. Instead of hauling out the backhoe or firing up an incinerator to dispose of human remains, funeral directors could offer a method called alkaline hydrolysis or “bio-cremation.” This technique uses hot water, pressure, and potassium-sulfate (the strongly basic chemical often referred to as lye) to break down the body’s tissues into simple molecules in a matter of a few hours. Proponents of bio-cremation say it’s the eco-friendly death option. They note that cremation produces air pollution and greenhouse gases, while burials use tons of wood for caskets and involve treating bodies with hazardous embalming chemicals. Four other states have already approved bio-cremation, but before funeral homes can offer the service, they have to figure out what to do with the environmentally friendly liquid remains. Last week, an undertaking service in Minnesota asked its local city council for permission to pour it down the drain. Out of respect …
Maybe the standard Sony Vaio P is a bit pedestrian for your taste. It’s just not enough, right? Well then, how about one covered with crocodile skin? It’s supposed to be a digital clutch anyway.
Pricing info isn’t available, but it’s not going to be low-cost. The model’s spec’d out with the Atom Z560 Intel US15X chipset, 256GB SSD, and optional 12-hour battery. Plus all that crocodile skin can’t be cheap. [SonyBrands via eeepc via liliputing]
Today I jogged through Amsterdam from the Royal Palace on Dam Square to the mouth of the river. Like many European city centers, Amsterdam has evolved into a super mall, an old surface covered with the images of models posing with products, often in gigantic proportions. There is a spell cast on me, regardless of […]
iLuv, one of a number of manufacturers of Apple accessories, has added three small and portable speaker options that provide high quality sound while eliminating cable clutter. The three speaker options include a mini clip speaker, a portable speaker bar and a pair of newly designed cube speakers, all powered by USB to reduce cable clutter on the desktop. All three speaker designs work with Mac or PC…
Continue Reading iLuv’s speaker trio for iPad, Mac and PC
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You can get a PDF file viewer anywhere, but we all know that Adobe does it the best, and it just released an official Adobe Reader app [Market link] for Android. First impression is its pure simplicity, and I mean that in a good way. Now, before you get excited – make sure you’re running Éclair, and have at least 550MHz CPU with 256MB of RAM, or else it’s just not going to be a smooth experience.
This is a post by Android Central. It is sponsored by the Android Central Accessories Store
Filed under: Ford, Design/Style
While Volvo’s fate isn’t perfectly clear yet, it appears that everyone might have been best served by Ford severing ties with the foreign branches of its Premier Automotive Group: Aston Martin, Volvo, Land Rover and Jaguar. True, Ford didn’t get to fully benefit from the labor it put into the cars those brands are unveiling to accolades right now, but it spared itself the continued financial and brain drain on its core brands.
It was a drain that was also felt by the company’s design arm, headed by J Mays. Referring to how thin The Blue Oval’s design resources were stretched, Mays called the efforts “an inch deep and a mile wide.” Part of it was that there were simply so many new models to keep track of, the other part being that so many of those cars had such vastly different requirements – an Aston couldn’t look like a Lincoln, and even though an Aston could use Volvo’s switchgear it shouldn’t look anything like S80 or an XF.
Now the team can focus on wrapping the company’s products and concept cars (like the Ford Start shown above) in the “Post-Kinetic” design language developed a few years ago. That, Mays says, is also easier because of Ford’s rationalization of its platforms – something that also could not have been as completely without selling the company’s PAG brands.
Gallery: Ford Start Concept
[Source: Ward’s Auto]
Life much easier for Ford designers in a post-PAG world originally appeared on Autoblog on Tue, 25 May 2010 16:29:00 EST. Please see our terms for use of feeds.
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So the iPhone 3G has been discontinued, and now Wal-Mart has gone and lowered the price of the iPhone 3GS down from $197 to $97—a full $100 drop. The change gives credence to the rumor that Apple will be dropping the price of the iPhone 3GS to $99 with two-year contract, and that the 3GS will take the place of the 3G as the entry-level iPhone device. As we stated previously, we thought it would behoove Apple to keep the 3G around as the free with contract phone, then use the 3GS as the $99 device, and finally use the iPhone Pro as the flagship model. We think that would be a good price structure to take on Android, but hey, we aren’t Apple—let’s see where this all ends up.
In the meantime though, as enticing as a $97 iPhone 3GS might sound, just wait to see what gets announced at the WWDC 2010 keynote first, m’kay?
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Cuando aún estamos procesando la información que ha llegado desde el Salón de Madrid, y entre las marcas participantes tenemos a la propia BYD que llegará a nuestro país a través del conocido Grupo Bergé, una noticia curiosa nos llega desde oriente.
Según publican en Autoblog, BYD lanzó al mercado el F3DM a finales de abril, modelo que pudimos ver en Madrid, y sólo ha conseguido vender 13 unidades de este híbrido que según la firma china es el modelo híbrido más barato actualmente en el mercado.
Pero precisamente de ahí viene el problema en China, puesto que no se han definido aún las ayudas del gobierno asiático a este modelo, que podrían rebajar el precio del coche en 7.000 euros, por lo tanto hasta los 11.800 euros al cambio (100.000 yuanes). En nuestro país pese a aparecer en el catálogo MOVELE no tiene ayuda definida este modelo, ni tampoco el E6 y aún queda por saber con que precios llegará a los mercado europeos BYD con sus dos modelos híbridos.
Vía | Autoblog en español
by David Hanson
The second dispatch from the Breaking Through Concrete team, who’re driving across America in a biodiesel-fueled bus to document the urban-farm movement.
The Santa Cruz Homeless Garden Project grows more than 4,000 strawberry plants.(Michael Hanson photos)The day began in the parking lot of a real estate office off Hwy 17 south of San Jose. We parked Lewis Lewis there after the long drive from Medford, OR. Sleeping at a gentle downslope angle, we hoped not to hear the window tap and see the bright white light of a California Highway Patrol officer’s mag light telling us we can’t overnight park here. But there were no rude awakenings or spicy dreams about Officer Poncherella, and we rolled out early, arriving at 7am to the Santa Cruz Homeless Garden Project‘s Natural Bridges Farm on the north side of Santa Cruz, Calif.
Paul Glowaski, farm director(Michael Hanson)Within a few minutes, we were eating breakfast strawberries and drinking coffee with David, one of the farm’s trainees. By nightfall, we would be back in the same spot sipping bourbon and eating dessert strawberrries with the farm director. As usual, it’s what happens between the coffee and the toddy that makes up a day.
The Homeless Garden Project is a 20-year-old success story that began as a small plot and a thousand donated herb plants tended by a few homeless men and women. It now employs 14 homeless trainees and provides weekly CSA shares to over 80 members of the Santa Cruz community.
People might wonder if the name isn’t demeaning. Yeah, we get that sometimes,” says Paul Glowaski, 31, farm director. “But at some point you’ve got to stand up and say, ‘This is who we are, we’re people.’”
The Homeless Garden Project is not a charity case. It grows beautiful organic produce to rival any small farm’s in the country—deep shades of purple and maroon and green and yellow in the rainbow chard rows, artichoke stalks as tall as a man, strawberries the size of crabapples, kale, broccoli, squash, lettuce, spinach, bok choi, lavender, wheat (they make pancake mix), and rows of cut flowers. It just so happens that homeless people, given a chance at gainful employment for up to three years, are the ones moving the plow, lining the irrigation tubes, harvesting the goods, learning job skills, and enjoying the satisfaction of responsibility and community.
“We hit both sides,” says Glowaski, a passionate man whose turquoise eyes almost tear up when he talks about the farm. “The progressives love us because we grow organic food and offer a social service and conservatives love us because we provide job training.”
The farm is about to go crazy. Already the strawberries are lying fat and drunk in their sugary juices. The trainees—the term for employees—crouch between the rows and pluck them off, chatting and laughing.
Robert, a Santa Cruz Homeless Garden trainee, in the shelter where he now lives.Robert arrived two months ago when he took a bus away from San Francisco and the bad scene he’d fallen into there. He’s lean and he smiles a lot. His voice is deep as a blues singer, but still all young and caramel smooth. He walks or takes the bus here from the homeless shelter, and he saves his money from the hourly farm wage he gets for working 20 hours a week. His training program began in early spring. He tells us about how amazing it feels to plant something, watch it grow, then pull it and share it with someone.
Darrie Gaznhorn has been the executive director of the Homeless Garden Project for almost the entire 20 years. She works in the project’s gift shop in downtown Santa Cruz, for which trainees make wreaths and candles and other value-added farm wares during the winter. Gaznhorn’s worked with hundreds of trainees, and she’s seen some move on to success and others slide back down the wrong side of life. Although HGP doesn’t call itself a horticultural therapy project, therapy and recovery—in addition to concrete job skills—are intrinsic in a farm.
“Food has incredible meaning for survival. It’s so needed and tangible and there’s such satisfaction in planting a seed and seeing it grow. You see results,” she says. “People say that when they’re weeding, they’re throwing away the bad thoughts. They see the clean row in front of them and this pile of bad stuff off to the side. Farming and providing food for people is an honorable thing, and it’s very healing.”
We stand at the edge of the Sonora wheat, a 16th-century heirloom seed brought up the coast by the Spanish missionaries and cultivated at HGP. Glowaski talks about his generation—our generation—and how it has a different approach to the nonprofit world than the one established by our parents’. He doesn’t like asking for money, preferring instead to aim for the new buzz in business planning: the Triple Bottom Line, the triangle formed by ecological, social, and economic values. It’s easy to see businesses that miss the ecological and social part; just watch the news. But many nonprofits, especially production urban farms, no longer want to settle for fundraisers and grants; they want and need to hit the economic corner of the triangle.
The sun takes its time setting and the wind is cold. The trainees have left but Glowaski’s still here. This is his time to chill. He says at this crepuscular hour the farm reveals itself in a brief moment of soft colors when everything alive is moving, either coming or going.
Here’s Glowaski talking about HGP:
Related Links:
Breaking Through Concrete: Day 1 – Seattle to Talent, Ore.
Boost your support for urban agriculture with a rice-growing bra
Rooftop farming and beekeeping boom in New York
Gaga’s ready for her closeup — on CNN’s Larry King Live!
According to King’s Twitter feed, the bespectacled interviewer will sit down for a chat with the new Princess of Pop during his top-rated primetime talk show next week.
King Tweeted on Monday evening: “Are you ready for this? Coming next week to Larry King Live…. @LADYGAGA!”
Seagate has revealed a hybrid solid state/hard drive which is claimed to be “the world’s fastest 2.5 inch laptop PC hard drive.” The Momentus XT offers users the price and capacity benefits of a hard disk drive and the speed advantages of solid state memory in one laptop-sized drive…
Continue Reading Seagate Momentus XT hybrid claimed as world’s fastest laptop drive
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![Click here to read Valve Parodies Apple's "1984" Commercial](http://cache.gawkerassets.com/assets/images/4/2010/05/160x120_uoiy7i0f78y.jpg "Click here to read Valve Parodies Apple's "1984" Commercial")
