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  • Andrew Wakefield, martyr | Bad Astronomy

    [Note: I expect antivaxxers to flood the comments below with their typical spin and distortions. I urge everyone to read my comments policy. I also note that the article here is extensively linked to other sources backing up my claims about Wakefield and the antivax movement. The debunking of the vast majority of antivax claims can be found in those links.]

    Andrew_WakefieldAndrew Wakefield, the man who more than anyone started the modern antivaccination movement that has led to the rise of measles, pertussis, and other preventable diseases, has been struck off the UK General Medical Council’s register. The GMC registers doctors in the UK, and oversees their conduct. To be struck off is essentially the same as being disbarred.

    This is indeed good news, but forgive me if I don’t dance in the streets. It hardly makes any difference, and is years too late.

    In 1998, Wakefield published a paper which led to people thinking vaccines caused autism. His research was shoddy, poorly done, unethical, and, frankly, wrong. Eventually the original paper was withdrawn by the medical journal in which it was published.

    Syringe, from http://www.flickr.com/photos/8499561@N02/2756332192/That’s all great, in that eventually truth won out. But has it, really? Sure, he’s disbarred, and reality-based people understand he’s totally wrong. But the antivax movement still rolls on. Wakefield moved to Texas where he still spreads his antivax propaganda; he was on NBC’s TODAY show just this morning — what a coincidence! — still proclaiming his innocence, and still spreading falsehoods about vaccines.

    And falsehoods they are. From the NBC page:

    When [host Matt] Lauer asked Wakefield whether it’s dangerous to continue promoting an MMR-autism link when it causes many families to shy away from vaccinating their children, Wakefield answered, “Matt, you’re missing the point.

    “The point is that despite denying it, in the public relations campaign they’ve used against me and against the parents, they are conceding these in vaccine court.”

    Actually, that’s completely wrong, and he should know better. For one thing, courts have ruled over and again that there is no evidence to link vaccines and autism. What Wakefield is most likely referring to is the Hannah Poling case, which can be twisted and spun into making it sound like it connects vaccines and autism, but it doesn’t. Read Steve Novella’s entry on that case to see how once again the truth eludes Wakefield.

    For another, Lauer was not missing the point at all. Wakefield was dodging the point. Lauer was precisely correct; it is dangerous to promote a link that doesn’t exist between autism and vaccines, for exactly the reason Lauer stated.

    It would’ve been interesting indeed to see Matt Lauer following up that question with asking Wakefield about his huge financial conflict of interest in all this, since Wakefield was developing an alternative to vaccines when he wrote that paper. Or if he had anything to say about investigative journalist Brian Deer — a man who has been at the forefront of exposing Wakefield all along — and the evidence he found that alleges Wakefield was paid by lawyers to start a vaccine scare?

    Anyway, for years Wakefield has been claiming he’s the victim here. This news won’t change that, and will in fact make him a martyr to his reality-impaired followers.

    He’s not the victim here. The real victims are people who get measles, people who get rubella, people who get pertussis. Most of the time these folks recover and are fine, though miserable. But sometimes it’s not such a happy ending. Dana McCaffery, a four month old girl in Australia, died last year because the herd immunity was too low where she lived. Because people chose not to vaccinate — and the antivax movement was strong there — that little girl died.

    We’re seeing outbreaks of vaccine-preventable diseases all over the world, and in many of those regions the voices of Wakefield and the antivaxxers are strong. I’m glad the GMC finally took action and did the right thing, but this does not mean we must rest in our fight against those zealots who believe — without any evidence, and plenty of evidence against them — that vaccines cause autism.

    They don’t. But how many kids will get sick before everyone finally realizes that?

    Syringe picture from ZaldyImg’s Flickr photostream, used under the Creative Commons license.


  • Hepatitis C Bulletin: Beware of Eltrombopag!

    Although eltrombopag may help some people complete Hepatitis C therapy and thus beat the virus, learn why the FDA is warning physicians that this platelet-boosting drug poses a risk to those with chronic liver disease.

    by Nicole Cutler, L.Ac.

    Following the latest news updates on medications that you have been or could be prescribed is a monumental and often frustrating task. This is especially true for those living with chronic Hepatitis C, since new developments related to this illness seem to emerge on a daily basis. A recent report from the U.S. Food and Drug Administration (FDA) has delivered news that ranks high on the priority list of things those with Hepatitis C should be aware of. In collaboration with the FDA, GlaxoSmithKline unveiled important information about the platelet-boosting drug eltrombopag (Promacta), specific to individuals with liver disease.

    What Is Eltrombopag?
    To help those with a blood-clotting problem, eltrombopag is a medication that increases the production of platelets. Other drugs that can restore normal platelet functions are infusions or injections, while eltrombopag has the advantage of being a pill taken just once a day.

    Irregularly-shaped, colorless cells that are present in blood, platelets have a sticky surface that helps them form clots to stop bleeding. This function is necessary, because the human body does not handle excessive blood loss well. Thus, individuals who have low levels of platelets in their blood run a substantial risk of a dangerous bleed. There are a handful of conditions that could lead to low platelet levels. Because it is one of the most severe side effects of ribavirin, a low platelet count is the most prominent reason for discontinuing Hepatitis C combination therapy (pegylated interferon and ribavirin).

    Eltrombopag Used for Hepatitis C
    Following a 2007 study by Duke University Medical Center researchers, eltrombopag has been a medication preferred by some hepatologists for certain individuals with Hepatitis C. According to the study involving Duke and other centers worldwide, eltrombopag was found to boost platelet levels of a majority of patients with low platelet counts and cirrhosis of the liver due to Hepatitis C infection.

    Completing the fully prescribed course of Hepatitis C combination therapy offers those with this liver disease the most hope for recovery. Unfortunately, many must discontinue Hepatitis C treatment because of its severe side effects. By capitalizing on the platelet-boosting action of eltrombopag, patients with low platelet counts were deemed eligible for beginning or continuing Hepatitis C combination therapy – giving them a better chance of eliminating the virus.

    The Eltrombopag Warning
    Despite the appearance of eltrombopag being a savior for many people trying to complete Hepatitis C treatment, a new safety finding reveals just the opposite. Upon this discovery, the FDA has begun notifying healthcare professionals to be aware of eltrombopag increasing the likelihood of a venous thrombus in those with chronic liver disease. Also known as a blood clot in a vein, a venous thrombus located in deep veins is a major risk for a pulmonary embolism – a potentially fatal event. Although the study revealing this trend was small, there was a clear tendency to forming venous blood clots in participants who took eltrombopag compared to those taking a placebo. While GlaxoSmithKline is working with regulatory agencies to include more specific safety information on eltrombopag’s label, here is what you should know:

    · Eltrombopag should be aimed at increasing the platelet count to a level that reduces the risk of bleeding – not for bringing the platelet count up to normal.

    · Additional caution should be exercised when administering eltrombopag to those with Hepatitis C, including lower dosages and monitoring the patient closely.

    Any course of therapy must carefully weigh potential risks with the possible benefits. When it comes to fighting Hepatitis C, this analysis gets complicated, especially if managing low platelet counts during antiviral therapy. Your healthcare provider should be aware of this new warning by the FDA. However, we are always our own best advocates, so make sure you know about the potential risk of using eltrombopag during Hepatitis C therapy.

    References:

    http://www.docguide.com/news/content.nsf/news/852576140048867C8525772100737C12, FDA Warns Against Eltrombopag Use in Patients With Chronic Liver Disease, Retrieved May 17, 2010, Doctor’s Guide Publishing Limited, 2010.

    http://www.drugs.com/mtm/eltrombopag.html, eltrombopag, Retrieved May 19, 2010, drugs.com, 2010.

    http://www.fi.edu/learn/heart/blood/platelet.html, Platelets: Sticky Situations, Retrieved May 19, 2010, The Franklin Institute, 2010.

    http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=1;spage=51;epage=56;aulast=Danish, Considerations in the management of hepatitis C virus-related thrombocytopenia with eltrombopag, Fazal A Danish, et al, Retrieved May 17, 2010, The Saudi Journal of Gastroenterology, January 2010.

    http://www.sciencedaily.com/releases/2007/11/071128172408.htm, Pill Boosts Platelets In Hepatitis C Patients, Retrieved May 17, 2010, ScienceDaily LLC, 2010.

  • Apple’s five stages of Google grieving

    By Joe Wilcox, Betanews

    Grief typically follows any breakup, whether by the living separating or death taking one away. Apple’s response to the disillusion of its Google relationship is near textbook case of the five stages of grief: denial, anger, bargaining, depression and acceptance. Apple is slowly coming to terms with life after Google, and like any grieving the process hasn’t been easy.

    Denial. Two years before Apple released iPhone, Google bought Android. From the August 2005 acquisition, it was clear that Google would make mobile a priority, and surely that a phone would follow. “We did not enter the search business. They entered the phone business,” Apple CEO Steve Jobs told employees during a March meeting. Google released Android OS about 18 months after iPhone launched in June 2007, but the product was foreseeable. Jobs’ retort is classic denial behavior.

    Jobs’ claim that Apple “did not enter the search business” is another form of denial. Google’s search business is all about monetization through advertising. Apple’s iAd is such potential advertising competition to Google that last week the US Federal Trade Commission cleared way for Google’s AdMob acquisition; before Apple announced iAd, the agency indicated the acquisition could be blocked.

    Anger. Jobs’ temper is renown around Silicon Valley. Apple’s anger against Google is simply undeniable; there are so many examples. Jobs has personally attacked Google in e-mails to Apple customers and partners and through public statements. In March, Jobs reportedly said that Google’s oft-quoted “You can make money without doing evil” is “bullshit.” Some of those angry statements exhibit deep denial, too, such as Jobs’ early April assertion that: “Search is not happening on phones.” Who is he fooling but himself?

    Apple’s HTC lawsuit is a form of repressed anger. While Apple sued HTC, the claims are really about Android and Google. Can you say passive-aggressive behavior?

    Bargaining. Google’s advances on Apple extend beyond the phone. There is the browser; according to Net Applications, Chrome usage now exceeds Safari. Google released Chrome about the same time as Android, rapidly iterating on the browser — now approaching version 5 — for technology developed first by Apple; Chrome is based on WebKit. In a clear swipe against Chrome innovations, Apple bargained with developers during the iPhone 4 OS announcement, on April 8, with new Safari features that extended some of Chrome’s best capabilities. Chrome sandboxes tabs to improve performance and to minimize crashes’ effects. Apple will go further with kernel-level multi-processing.

    Jobs’ “Thoughts on Flash” is more bargaining. While seemingly all about Adobe, Apple’s anti-Flash campaign is as much about Google. As I explained last month, Apple and Google are taking two different, fundamentally clashing approaches to the mobile Web. Apple’s approach is more applications-centric, while Google puts greater emphasis on the browser. Google supports Flash, which is coming with Android 2.2 (some people have already; you lucky bastards). Google arguably will embrace the real Web, not the one Jobs is bargaining to makeover.

    Depression. Jobs has been remarkably prolific over the last couple months responding to customer and developer e-mails. It’s commendable that such a prominent CEO is taking such an active role in such an unorthodox way. C`mon, how often do you read about the chief executives of GM, Microsoft or Pepsico responding to so many customer or partner e-mails? But the timing indicates post-Google breakup depression. Jobs’ prolific responses started after Schmidt resigned from Apple’s board (late summer 2009) and Apple-Google sniping reached public levels (early 2010). Actually, the e-mails are mixed denial, anger and depression.

    Acceptance. The e-mails also signal Apple’s acceptance — that Google is a competitor in mobile operating systems and Web browsers, and that the two companies will clash over customers, developers and other partners. In response to a May 22nd e-mail about last week’s Gizmodo article asserting that “Google is leapfrogging Apple,” Jobs reportedly responded: “Not a chance!” Google is buddy no more, but the enemy. If there was a sixth stage to grief, betrayal, Apple could be said to exhibit it, too.

    Apple’s HTML 5 push is another form of acceptance, but more self-destructive. While Apple positions HTML 5 as an alternative to Flash, the technology looks to benefit Google much more than Apple. Already Google has used HTML 5 to circumvent Google Voice’s prohibition from the iTunes App Store.

    Do you have more examples of Apple’s five stages of Google grieving? Please offer them up in comments.

    Copyright Betanews, Inc. 2010



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  • Sprint Evo 4G hardware hands-on

    Sprint Evo 4G with Android 2.1 and Sense

    The Sprint Evo 4G isn’t all that new to us, having been at its announcement at CTIA in March and its coming-out party in New York City just a few short weeks ago. But it’s finally time to properly put the 4.3-inch WiMax monster through its paces. And we’re going to start with the hardware. Join us after the break as we unbox the black slab.

    This is a post by Android Central. It is sponsored by the Android Central Accessories Store

  • Judge Throws Book & Booze Bracelet At Lindsay Lohan

    No alcohol, no drugs, no work outside of Los Angeles, and a not-so-trendy new bracelet — those are just a few of the rules Lindsay Lohan will have to abide by if she wants to remain free, a California judge said Monday.

    Lohan avoided arrest after failing to show up for probation hearing by posting $100,000 bail, but still faces the other conditions imposed by the judge. In an early morning hearing in Los Angeles, Superior Court Judge Marsha Revel ruled that Lohan could remain free on bail, but she cannot consume alcohol, must wear an alcohol-monitoring bracelet, is not allowed to leave the Los Angeles-area, and will have to submit to random weekly drug testing.

    While a frustrated Lindsay looked on, her attorney — Shawn Chapman Holley — argued that the actress is beginning filming of a movie in Texas and needs the court’s OK to travel. Tough titty, says the judge, who suggested LiLo delay the start of the project. The bracelet — a SCRAM device — must be in place within 24 hours, per Judge Revel’s order.

    Last week’s scheduled hearing involved a progress report on her probation stemming from two arrests in 2007. A July 6 court date has been set to review that matter. If it is determined that Lindsay has violated her probation in any way, she could face up to 180 days in jail.


  • AT&T’s Tarnished $1.4B Sterling Sale

    AT&T said today it’s agreed to sell its Sterling Commerce software division to IBM for $1.4 billion. The deal will let AT&T offload a business unit that SBC Communications bought for $3.9 billion at the height of the dot-com boom (SBC went on to buy AT&T in 2005 but kept the iconic telecom name). Sterling offers pricing and e-commerce software that businesses can use to manage pricing in real time or to get an entire view of their inventory, from marketing to fulfillment.

    However, AT&T isn’t a software company, and the original rationale behind buying Sterling — namely that the phone company could become an exchange for online pricing — never panned out. So even though the sale price is much less than what SBC paid back in 2000, the deal is a good way for AT&T (which never integrated Sterling into its business) to get rid of a non-core asset. IBM’s acquisition will pit it against similar software from HP and other large enterprise software providers, which is where Sterling belongs anyhow.

    Image courtesy of Flickr user zzzack



    Atimi: Software Development, On Time. Learn more about Atimi »

  • Facebook Doesn't Adhere to Its Stated 'Principles'

    Facebook has faced backlashes before, but this time feels different. Despite amassing an empire of nearly 500 million users, the company is in the midst of a public relations fiasco, with users, tech columnists and even the FTC slamming CEO Mark Zuckerberg for privacy violations. So Zuckerberg took to the Washington Post today to defend Facebook’s record and name the company’s leading principles.

    There’s just one problem. If these are Facebook’s principles, the company isn’t doing a great job adhering to them. Let’s look at the first three:

    1. “You have control over how your information is shared.”

    Is it fair to say users have control over their information if the rules governing the information keep changing?

    In 2007, no Facebook information was public to the broader Internet. At the end of 2009, basic stuff like name and gender became searchable through Google. In December, the company added “likes” and friends to the Internet-public stockpile. In April 2010, it added photos. Without pressing a button, the average default public user would have seen dramatic changes in how his information was shared through Facebook between 2007 and 2010.

    The company is working on a simplified privacy system in the next few months, and one hopes that it will be simple, intuitive and wary of the balance between those who want to lock down all of their information and those who don’t mind transparency. But the fact is, it’s in Facebook’s business interest to have users default to public and then to slowly grow the definition of the word public. Facebook’s privacy rules have evolved and personal control over information has sometimes been a casualty of that evolution.


    2. “We do not share your personal information with people or services you don’t want.”

    This is a strange principle for a company now infamous for sharing personal information with people and services users didn’t expect. Examples abound, but Time magazine’s Dan Fletcher noted one of the more infamous episodes in a new article:

    In 2007… default settings in an initiative called
    Facebook Beacon sent all your Facebook friends updates about purchases
    you made on certain third-party sites. Beacon caused an uproar among
    users — who were automatically enrolled — and occasioned a public
    apology from Zuckerberg.

    In another snafu, Zuckerberg’s photos surfaced on the Web — some were excerpted by Gawker — before he reclaimed them behind the privacy wall. Facebook’s privacy rules and updates have been so complicated and messy that even its founder and CEO has been a victim.


    3. “We do not give advertisers access to your personal information.”

    Before we parse this statement, let’s review the company’s ad strategy. Facebook gives advertisers access to buckets of information. So if Ford wants to show ads to a 30-year old in D.C. who likes red sports cars, Facebook can scrape together all the thirtysomethings in the D.C.-area who express an interest in sports cars or The Fast and the Furious and put targeted ads by their pages.

    Does this count as giving advertisers access to personal information? It’s tricky. Ford does not get to see a list of names. Instead it gets to show its products to a pool of Facebook users. But the more you share, the more access advertisers get. As the Time cover story explains, “if three of your friends click a
    Like button for, say, Domino’s Pizza, you might soon find an ad on your
    Facebook page that has their names and a suggestion that maybe you
    should try Domino’s too.”

    At best, these principles are conspicuously inarticulate attempts to
    split the difference between Facebook’s business interest (openness)
    and users’ chief concern (privacy). At worst, Facebook is engaging in
    corporate recidivism — shoving its privacy settings toward publicity,
    apologizing with an homage to privacy, and then swiftly re-offending.

    ______

    The weird thing about all of this is that, as a user, I don’t really care. I’m Facebook friends with my boss, my colleagues, and my mom. I don’t place (or leave) information on Facebook I don’t want public. Sure, there are some photos of me I would rather not appear on the 5 o’clock news. But I certainly wouldn’t think of leaving Facebook in indignation over the privacy updates, complicated as they are.

    As somebody who’s interested in the future of the Web and Web-advertising, I do care, quite a bit. See, I actually like what Facebook is trying to do with Open Graph, which collects articles and information that users “like” on Facebook widgets throughout the Web and pools it together to personalize our experience on sites like Yelp, Pandora, and the Washington Post. But when Zuckerberg goes national with equivocal statements like the ones above about privacy and user expectations, he damages the potential of his brand and his ideas.





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  • Tata completes Nano fire probe, says car is safe

    Filed under: , , ,

    Earlier this year, there were reports of at least three Tata Nano runabouts channeling The Trammps and going up in Disco(unt) Infernos. Of the three Nanos that got the charbroil treatment, two of them were apparently due to a faulty switch. The third couldn’t be explained, so Tata put together a team of 20 employees supplemented by a forensics expert to figure out what was going on.

    Without explaining what happened, the team has reportedly “found no manufacturing defects,” and according to PTI News, they say that the third incident is unrelated. Furthermore, all Nanos “absolutely safe.” As you were, then. Still, in case current Nano owners want to be even more than absolutely safe, Tata will preemptively check any vehicle already in service.

    [Source: PTI News]

    Tata completes Nano fire probe, says car is safe originally appeared on Autoblog on Mon, 24 May 2010 11:40:00 EST. Please see our terms for use of feeds.

    Read | Permalink | Email this | Comments

  • You Need a USB Port Cleaner as Much as You Need a Colonics Session [Accessories]

    Only $17 and some plugin-plugout action separate you from shiny USB ports. Why do you need that? No idea. But as one of my teachers used to say in high school: “Remember kids, always keep all your ports clean.” [Brando] More »







  • Join Gizmodo, LifeHacker, and Jezebel for Drinks Tonight in NYC [Announcements]

    If you live in the area and can carve a little extra time into your calendar, join Gizmodo, Lifehacker, and Jezebel at Sweet and Vicious in New York City (on Spring Street between Elizabeth and Bowery) later tonight. We’ll be heading that way after 6 (and will stick around until at least 7:30), and look forward to seeing you there! Photo by Stewart. More »







  • Yahoo Dumps ‘Personals’ for Match.com’s Online Dating Services

    Yahoo is continuing its slim-fast diet and shedding yet another one of its services. Yahoo Personals is to be no more, as the service will be outsourced to IAC’s Match.com. Existing users will be able to switch over to the new service dubbed “Match.com on Yahoo.” The move is the latest in a long line of outsourcing d… (read more)

  • 54,000 More HP Batteries Recalled

    Hewlett-Packard doesn’t just make props for cringeworthy feature length commercials; the company also sells batteries that sometimes catch fire. A year ago HP recalled about 70,000 bad batteries, and now it’s added another 54,000 to the list.

    The batteries and the laptops they came with were sold between August 2007 and July 2008. Even if you cleared your battery during last year’s recall, you may want to check again to see it’s been added to the list. The CPSC has a full list of the notebook and battery ID numbers, or you can check out the official HP recall page. You can also call HP at 1-800-889-2031 between 7am-7pm CT Monday through Friday.

    “HP Expands Recall of Notebook Computer Batteries Due to Fire Hazard” [CPSC]
    HP Notebook PC Battery Pack Replacement Program [HP]

  • Gutierrez, Quigley want immigration reforms to cover gay couples

    below, release….

    REPS. GUTIERREZ, QUIGLEY CALL FOR INCLUSION OF SAME-SEX COUPLES IN COMPREHENSIVE IMMIGRATION REFORM

    Congressman Gutierrez: “Our efforts to fix our broken immigration system and protect basic civil rights are not truly comprehensive if we exclude same-sex couples.”

    Congressman Quigley: “The beauty of America is that somewhere in each of our lineages, someone made the choice to come here, to a country built on fairness and justice. We must continue to honor that tradition not just for some, but for all families.”

    CHICAGO – Congressman Luis V. Gutierrez, the sponsor of the Comprehensive Immigration Reform for America’s Security and Prosperity Act of 2009 (CIR ASAP), and a national leader of the fight for immigration reform and fairness efforts, and Congressman Mike Quigley, a CIR ASAP co-sponsor and leading voice for LGBT equality, will join with LGBT leaders to hold a press conference in Chicago on Monday to announce their strong support for inclusion of same-sex couples and their families in comprehensive immigration reform efforts in Congress this year.

    WHAT: Rep. Luis V. Gutierrez, Rep. Mike Quigley, Rep. Jared Polis, LGBT community leaders and advocates announce plans to include same-sex couples and their families in immigration reform

    WHEN: Monday, May 24, 2010
    12:00pm CT

    WHERE: The Center on Halsted
    3656 N. Halsted
    Chicago, Illinois

    WHO: Congressman Luis V. Gutierrez (D-IL-4)
    Congressman Mike Quigley (D-IL-5)
    Congressman Jared Polis (D-CO-2)
    LGBT and Immigrant Leaders and Families, TBD

    CIR ASAP (H.R. 4321), Gutierrez’ comprehensive bill cosponsored by 97 other members, does not currently include a specific provision extending legal immigration benefits to bi-national same-sex couples and their families. However, the Congressman is recommitting himself to inclusion of a specific provision that would allow an American citizen in a committed same-sex bi-national relationship to petition for an immigrant visa for their permanent partner in the same manner as an heterosexual couple would. This would ensure that all American families can remain together through the immigration process. As many as 40,000 couples – many with American citizen children – would benefit from the provision. Other key provisions of CIR ASAP, including legalization provisions for undocumented residents, asylum policy reforms, and treatment in detention, already apply to lesbian, gay, bisexual and transgendered persons.

    Congressman Gutierrez will be joined at the press conference by Reps. Mike Quigley (D-IL) and Jared Polis (D-CO), who are each strong supporters of LGBT inclusion in immigration reform. Leaders from the LGBT and immigrant communities in Chicago are also invited to speak. Together they will announce their support for including same sex couples and their families in comprehensive immigration reform. They will also address the need for the LGBT and immigrant communities to be united in their efforts to pass legislation this year.

    Also participating in the press conference will be individuals who would benefit from the provision and who will tell their personal stories of their families being separated by America’s broken immigration system.
    ###

  • Kardashians “Nightline” Interview Sets Record Straight On Rumors

    The always-enterprising Kardashian women are setting the record straight on rumored plastic surgery, E!’s supposed wedding deal with Kourtney Kardashian-Odom, and Kris Jenner’s take on Kim’s nude centerfold on the pages of Playboy during a candid new interview with Nightline ABC Cynthia McFadden.

    Mom and Sisters dish tonight @ 11:35PM.


  • SoCal Angel Investing on Sluggish Pace as Investors Rethink Process

    Tech Coast Angels May 2010
    Bruce V. Bigelow wrote:

    Angel investing in Southern California remained sluggish during the first quarter of 2010, although individual investors’ overall mood seems to be improving, according to Tech Coast Angels chairman Richard Dudek.

    “Last year was the worst year since our inception,” says Dudek, a Laguna Niguel, CA, resident who oversees the 300-member organization. This is saying something, since the angel investing group was founded in 1997, merged with the San Diego Band of Angels in 2000, and now comprises five chapters throughout Southern California.

    The Tech Coast Angels made investments in five deals in the first quarter, and Dudek says, “I think we’re just slowly getting back to normal.”

    As we reported in March, the Tech Coast Angels says its members made $4.7 million in direct investments in seven new deals and 17 follow-on deals in 2009, and helped to attract an additional $57 million from other sources. The capital invested was down from $75 million in direct and affiliated investments, according to the Tech Coast Angels.

    During the first three months of 2010, Southern California’s angels invested about $1.6 million (out of a total $11.5 million) that went into funding five direct and follow-on rounds, according to Dudek. If this rate continues through the rest of the year, the Tech Coast Angels might not match the capital invested or the number of deals they did in 2009.

    But so far, it’s still too early to say. The Tech Coast Angels have been involved in three second-quarter deals that raised total funding of $2.9 million. One was for Amplyx Pharmaceuticals, a woman-owned biotech based in San Diego that Luke profiled last month. The angels also helped provide funding for Vokle, a live online video radio show based in the Los Angeles area, and MicroPower, a Beaverton, OR, designer of custom battery packs and charging systems.

    “In general, there is definitely a mood shift on the process of angel investing,” Dudek says. Where angels used to think about “the path to exit, they now look at what’s the path to funding,” Dudek says. “We need to be a lot more thoughtful about [the process] we need to get the company to that VC round.”

    The angels group, which is technically a nonprofit mutual benefit corporation, provided funding to two San Diego companies in the first quarter:

    Benchmark Revenue Management develops financial management software to help hospitals become more efficient and more effective through administrative efficiency gains facilitated by its technologies.

    Allylix has developed proprietary technology for producing a group of natural products called terpenes at low cost. In nature, terpenes are produced by plants in minute quantities and serve a variety of functions. Some act as flavors and fragrances, some are insect repellants, and others are anti-fungal, or anti-viral.

    The Tech Coast Angels also provided funding for three other startups in Southern California: Cyber-Rain, an Agoura Hills, CA, maker of wireless irrigation and waterflow control technologies; Vigilistics, an Irvine, CA, developer of industrial plant monitoring software; and H2Scan, a Valencia, CA, startup developing sensor technology that can detect hydrogen gas at concentrations as low as 15 parts per million.

    UNDERWRITERS AND PARTNERS



























  • Tunerfish Aims to Chart the Social Graph for Video

    A skunkworks project within Comcast dubbed Tunerfish that’s aimed at using game mechanics to chart the social graph for video was announced at TechCrunch Disrupt today. By enticing users to share what they’re watching with their friends, Tunerfish will create social recommendations while also rewarding those users for their influence in getting others to watch programming.

    Like a Foursquare for video, Tunerfish uses game mechanics to entice users to share what they’re watching with other members of their social circle, either through the Tunerfish site or a dedicated iPhone app, giving users badges and other awards for their checkins. Users can also comment on shows they or other are watching and have those comments show up on Twitter and Facebook.

    Users logged into the site are met with a list of trending shows, based upon what all Tunerfish users are watching, as well as a list of their friends’ activity. By charting which programs are popular, while also tracking what users are checking in and how they’re finding new types of content, Tunerfish will be able to build a sort of social graph for video viewing. The system will allow Tunerfish to determine the influence of certain users and provide awards as a result.

    According to John McCrea, founder of Tunerfish and VP of marketing for Comcast-owned social network Plaxo, the project was created by a team of four Plaxo developers in their spare time, from January through March. Once it got approval from Comcast execs, Tunerfish took on a life of its own.

    Tunerfish is currently in private alpha testing, but McCrea expects the site and a dedicated iPhone app to launch in public beta within the next few weeks. The group is also busy working on an Android app that will have all the same functionality.

    Related content on GigaOM Pro: New Business Models For Pay TV Services (subscription required)



    Alcatel-Lucent NextGen Communications Spotlight — Learn More »

  • Pandigital’s $200 Color e-reader Due in June, Supports Barnes & Noble

    Pandigital, a company known for digital picture frames, will be dropping their first e-reader, the Novel, next month. For $200, users will get a 7-inch color touch screen, WiFi (802.11 b/g/n) connectivity, and 1GB of internal storage. Like many other e-readers, the Novel supports PDF, EPUB, and HTML formats and features a mini-USB port for transferring files to and from a PC or Mac. There will be full support/integration with the Barnes & Noble eBookstore providing access to scores of books, magazines, and newspapers. Preloaded applications include a web browser, email client, alarm clock, and calendar. Don’t expect this to eat up too much of the nook market share as it will only have a limited release when it streets next month.

    Here’s a quick walkthrough of the Novel courtesy of CNET/Crave:

    Might We Suggest…

    • Devs Root the Barnes & Noble Nook

      “thought i would share this with you before going to bed. it took only 120 hours after launch (12/8/2009) 2 root #nook. world record? gnight”
      That was the last tweet from nookdevs last night. On…


  • Swaptree Gets New CEO, Funding

    Erin Kutz wrote:

    Swaptree, a Boston-based website enabling users to trade used books, DVDs, CDs, and video games, announced today that it has hired Jeff Bennett as its CEO, and said it has completed a $6 million round of funding. Bennett comes from NameMedia, a domain name marketplace, where he served as founder, president, and chief operating officer.  Swaptree’s newest funding round, led by Safeguard Scientifics, will go to new hires and marketing, and brings the company’s total capital raised to $11.95 million.  We wrote about the first $4.8 million of the round that the company pulled in during March.












  • Officially-licensed Street Fighter IV HDTVs are coming


    It’s a TV with Street Fighter IV branding. Just what the world needs. [ChipChick]


  • 8 Hedge Fund Managers Getting Hammered By The Fall In Financial Stocks (BAC, JPM, GS, C, CIT)

    David Tepper

    Financials have been a popular hedge fund investment since distressed debt became the investment en vogue back in 2009.

    And boy! Did they pay off in 2009.

    But each one of these managers stayed invested in financials last quarter (according to their 13F filings)…

    And if they’re are still in financials now, they’re getting hammered.

    Chris Shumway

    Chris Shumway

    Shumway Capital:

    • Almost $93 million in Bank of America (5.2 million shares)
    • $306 million in Goldman Sachs (1.8 million shares)
    • $163 million in JPMorgan (3.6 million shares)

    Phil Falcone

    Phil Falcone

    Harbinger:

    • $283.5 million in Citigroup (70 million shares)

    Steve Mandel

    Steve Mandel

    Lone Pine:

    • $273 million in Bank of America (15,277,033 shares)
    • Almost $800 million in JPMorgan (17,814,985 shares)

    Paulson

    Paulson

    Paulson & Co:

    • $3 billion in Bank of America (170 million shares)
    • ~$170 million in CIT (~4.5 million shares)
    • Over $2 billion in Citigroup (506.7 million shares)
    • $600 million in JPMorgan (almost 26 million shares)

    Bill Ackman

    Bill Ackman

    Pershing Square:

    • $91.5 million in CIT (2.35 million shares)

    Dan Loeb

    Dan Loeb

    Dan Loeb

    Image: screen grab from 1440wallsteet.com

    Third Point:

    • $91.6 million in Citigroup (2.35 million shares)

    David Einhorn

    David Einhorn

    Greenlight:

    • ~$420 million in CIT (10 million shares)

    David Tepper

    David Tepper

    Appaloosa:

    • $541.6 million in Bank of America (30.3 million shares)
    • $252.7 million in Citigroup (62.4 million shares)

    Now watch how their money disappeared over the last three months into each bank…

    Now watch how their money disappeared over the last three months into each bank...

    Bank of America (BAC) has dropped from $19.48 to ~$16.

    Bank of America (BAC) has dropped from $19.48 to ~$16.

    Goldman (GS) has gone from $184 to ~$140

    Goldman (GS) has gone from $184 to ~$140

    Citigroup (C) dropped from almost $5 to under $4

    Citigroup (C) dropped from almost $5 to under $4

    CIT went from $41.75 to ~$35

    CIT went from $41.75 to ~$35

    JPM fell from almost $48 to around $40

    JPM fell from almost $48 to around $40

    Ouch! Now see how they offset financials last quarter –>

    Ouch! Now see how they offset financials last quarter -->

    The 60-second guide to what hedge funds are invested in right now >

    Join the conversation about this story »