{"id":152699,"date":"2010-01-03T06:33:14","date_gmt":"2010-01-03T11:33:14","guid":{"rendered":"http:\/\/www.treatgene.com\/?p=442"},"modified":"2010-01-03T06:33:14","modified_gmt":"2010-01-03T11:33:14","slug":"hepg2-%e2%80%93-human-liver-cancer-cell-line","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/152699","title":{"rendered":"HepG2 \u2013 Human Liver Cancer Cell Line"},"content":{"rendered":"

HepG2 cells derived from a human hepatocellular carcinoma line (We et al.<\/em>, 2006). Hepatoblastoma (HB) or hepatocellular carcinoma is an embryonal malignancy<\/a> of hepatocellular origin and the most common primary liver tumor of childhood, usually presenting in the first year of life. I have described mcf-7, human breast cancer cell line<\/a> before.
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\nHepG2 cell line has been the subject of significant confusion for almost 30 years (Dolores et al.<\/em>, 2009). It has been found to express a wide variety of liver-specific metabolic functions (Norman et al.<\/em>, 1992). Therefore, HepG2 has been widely used in varieties of fields like liver metabolism, development, oncogenesis and hepatoxicity at that time in cancer research<\/a> (Dolores et al.<\/em>, 2009).<\/p>\n

\"hepG2<\/a>
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\nHepG2 cell line has been introduced since 1979 (Norman et al.<\/em>, 1992). Until now, there are more than nine thousands HepG2 references can be found in the scientific literature (Dolores et al.<\/em>, 2009). HepG2 cell line is known to be capable of producing many plasma proteins for which there are antisera commercially available (Liu et al.<\/em>, 1985).
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\nThis cell line has been proved to be an useful model of the human liver cell as there is high proportion of liver-specific proteins identified in the medium. The metabolic pathways that have been studied appear to simulate the behaviour of normal hepatocytes. Thus, those studies encourage a wider application of this HepG2 cell line to biologic problems that relate specifically to the role of the liver (Norman et al.<\/em>, 1992).
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\nReference:<\/em><\/p>\n

Dolores L-T, Sau W. C., Milton J. F. & Barbara B. K. HepG2 is a \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hepatoblastoma-derived Cell Line. Oncology Stat<\/em>, 1512 \u2013 1515 (2009).
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\nLiu M-C, Yu S., Jose Sy, Colvin M. R. & Fritz L. Tyrosine Sulfation of Proteins \u00a0\u00a0\u00a0\u00a0 from the Human Hepatoma Cell Line HepG2. Proc Natl Acad Sci<\/em> 82 \u00a0\u00a0\u00a0\u00a0 (21), 7160 \u2013 7164 (1985).
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\nNorman B. J. HepG2 Cells As a Resource for Metabolic Studies: Lipoprotein, \u00a0\u00a0\u00a0\u00a0\u00a0 Choresterol, and Bile Acids.\u00a0 The FASEB Journal<\/em> 4, 161 \u2013 168 (1992).<\/p>\n