{"id":170647,"date":"2010-01-12T11:59:38","date_gmt":"2010-01-12T16:59:38","guid":{"rendered":"http:\/\/www.diabetesforums.com\/forum\/type-1-5-diabetes\/47544-lada-tight-control-brand.html"},"modified":"2010-01-12T11:59:38","modified_gmt":"2010-01-12T16:59:38","slug":"lada-and-tight-control-brand-new-abstract","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/170647","title":{"rendered":"LADA and tight control brand new abstract !!"},"content":{"rendered":"<div>Diabetes Metab. 2010 Jan 7. [Epub ahead of print]<br \/>\nClinical and metabolic characteristics of patients with latent autoimmune diabetes in adults (LADA): Absence of rapid beta-cell loss in patients with tight metabolic control.<\/p>\n<p>Chaillous L, Bouhanick B, Kerlan V, Mathieu E, Lecomte P, Ducluzeau PH, Delamaire M, Sonnet E, Maugendre D, Mar\u00e9chaud R, Rohmer V, Sa\u00ef P, Charbonnel B.<\/p>\n<p>Clinique d&#8217;endocrinologie, maladies m\u00e9taboliques et nutrition, institut du thorax, h\u00f4pital Laennec, boulevard Jacques-Monod, 44093 Nantes cedex 1, France; Laboratoire d&#8217;immuno-endocrinologie, ENVN, Atlanp\u00f4le-La-Chantrerie, BP 40706, 44307 Nantes cedex 3, France.<\/p>\n<p>AIM AND METHODS: The present study compared the clinical and metabolic characteristics of latent autoimmune diabetes in adults (LADA) with type 2 diabetes, as well as the residual beta-cell function and progression to insulin treatment, over a 2-year follow-up period, of antibody (Ab)-positive and Ab-negative patients who achieved tight glycaemic control (HbA(1c) 7.0+\/-0.8% and 6.5+\/-0.9%, respectively, at the time of entry into the study). RESULTS: Glutamic acid decarboxylase antibodies (GADA) and\/or islet cell antibodies (ICA) were detected in 10% of patients presenting with non-insulin-dependent diabetes. Around half of Ab-positive patients required insulin treatment during the follow-up. Ab-positive patients displayed lower stimulated C-peptide levels both at entry and during the follow-up compared with Ab-negative patients, although no significant decline in C-peptide levels was observed in either subgroup over two years. Nevertheless, Ab-positive patients progressed more frequently to insulin treatment, and stimulated C-peptide tended to decrease in LADA patients who subsequently required insulin, whereas it remained stable in those who were non-insulin-dependent. In those who progressed, the trend towards C-peptide decline persisted even after starting insulin treatment. CONCLUSION: LADA patients demonstrate lower residual beta-cell function than do type 2 diabetes patients. However, those who achieve tight metabolic control do not present with a rapid decline in beta-cell function. Further studies are needed to determine the optimal treatment strategy in such patients. Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.<\/p>\n<p>PMID: 20060765 [PubMed &#8211; as supplied by publisher]:D <\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Diabetes Metab. 2010 Jan 7. [Epub ahead of print] Clinical and metabolic characteristics of patients with latent autoimmune diabetes in adults (LADA): Absence of rapid beta-cell loss in patients with tight metabolic control. Chaillous L, Bouhanick B, Kerlan V, Mathieu E, Lecomte P, Ducluzeau PH, Delamaire M, Sonnet E, Maugendre D, Mar\u00e9chaud R, Rohmer V, [&hellip;]<\/p>\n","protected":false},"author":362,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-170647","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/170647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/362"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=170647"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/170647\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=170647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=170647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=170647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}