{"id":239387,"date":"2010-01-27T13:27:02","date_gmt":"2010-01-27T18:27:02","guid":{"rendered":"http:\/\/www.technologytransfertactics.com\/content\/?p=5765"},"modified":"2010-01-27T13:27:02","modified_gmt":"2010-01-27T18:27:02","slug":"u-mich-develops-new-device-to-improve-in-vitro-pregnancy-rates","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/239387","title":{"rendered":"U-Mich develops new device to improve in vitro pregnancy rates"},"content":{"rendered":"

A device that gently rocks embryos while they grow during in vitro fertilization (IVF) improves pregnancy rates in mice by 22%, according to researchers at the University of Michigan. The device could one day lead to significantly higher IVF success rates in humans as well. Researchers built the device to imitate the motion that embryos experience as they make their way down a mammal’s oviduct (comparable to a woman’s Fallopian tube) to the uterus. Currently in IVF, eggs are fertilized with sperm and left to grow for several days in a culture dish that remains still until the embryos are transferred to the uterus. “By making the cells feel more at home, we get better cells, which is key to having better infertility treatment,” says Shu Takayama, PhD, associate professor in the department of biomedical engineering and in macromolecular science and engineering. Takayama and Gary Smith, PhD, associate professor in the department of obstetrics and gynecology at the U-M Medical Center, co-authored a paper detailing their findings in Human Reproduction<\/em><\/a>.<\/p>\n

Their device holds the tiny early-stage embryos in a thimble-sized funnel. The bottom of the funnel is lined with microscopic channels that allow fresh nutrient-rich fluid to flow in and waste products out. The funnel sits on rows of Braille pins that are programmed to pulse up and down, pushing the fluids in and out of the channels. The current generated simulates flows that occur in the body due to muscle contractions and the motion of hair-like cilia that line the oviducts. In the body, these motions help to push fertilized eggs to the uterus and flush out the eggs’ waste products. Compared with mouse embryos grown in a static dish, those incubated in the new dynamic device were healthier and more robust after four days. Approximately 77% of the rocked mouse embryos led to ongoing pregnancies, compared with 55% of the statically grown embryos. In a control group of mouse embryos conceived naturally and grown within the oviduct, 83% led to ongoing pregnancies. In humans, IVF currently has a success rate of about 35%. “If we could increase that, even just to 45%, that’s significant,” Smith says. Takayama and Smith founded the company Incept Biosystems, which has initiated human clinical trials of the device.<\/p>\n

Source: Science Daily<\/a><\/p>\n


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A device that gently rocks embryos while they grow during in vitro fertilization (IVF) improves pregnancy rates in mice by 22%, according to researchers at the University of Michigan. The device could one day lead to significantly higher IVF success rates in humans as well. Researchers built the device to imitate the motion that embryos […]<\/p>\n","protected":false},"author":67,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-239387","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/239387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/67"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=239387"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/239387\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=239387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=239387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=239387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}