{"id":290735,"date":"2010-02-07T15:56:38","date_gmt":"2010-02-07T20:56:38","guid":{"rendered":"tag:typepad.com,2003:post-6a00e54fc8012e88330120a86a673e970b"},"modified":"2010-02-07T16:01:20","modified_gmt":"2010-02-07T21:01:20","slug":"how-vitamin-d-works-answers-from-dr-bruce-hollis-its-role-in-cancer-musculoskeletal-pain-heart-disease-inflammation-infection-and-the-brain","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/290735","title":{"rendered":"How Vitamin D Works &#8211; Answers From Dr. Bruce Hollis&#8211;Its Role in Cancer, Musculoskeletal Pain, Heart Disease, Inflammation, Infection, and the Brain"},"content":{"rendered":"<div xmlns=\"http:\/\/www.w3.org\/1999\/xhtml\">\n<p style=\"text-align: center;\"><span style=\"text-decoration: none;\"><img decoding=\"async\" alt=\"VitaminDhype\" class=\"asset asset-image at-xid-6a00e54fc8012e88330120a86a6d5d970b \" src=\"http:\/\/www.happyhealthylonglife.com\/.a\/6a00e54fc8012e88330120a86a6d5d970b-250wi\" style=\"margin: 0px auto 5px; width: 250px; display: block;\" title=\"VitaminDhype\"><\/img> <a href=\"http:\/\/www.happyhealthylonglife.com\/.a\/6a00e54fc8012e88330128776cc739970c-pi\"><img decoding=\"async\" alt=\"Vitamindreceptors\" class=\"asset asset-image at-xid-6a00e54fc8012e88330128776cc739970c \" src=\"http:\/\/www.happyhealthylonglife.com\/.a\/6a00e54fc8012e88330128776cc739970c-250wi\" style=\"margin: 0px auto 5px; width: 300px; display: block;\" title=\"Vitamindreceptors\"><\/img><\/a> <\/span> <span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\">Ta<strong>rget tissues for Vitamin D&#8211;<em>Curr Opin Clin Nutr Metab Care 10:12-19, 2007<\/em><\/strong><\/span><\/span><\/span><\/span><\/span>\n<\/p>\n<div style=\"text-align: center; color: #000000;\">\n<p><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"> If you are receiving this via email <a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2010\/02\/vitamin-d.html\">click here <\/a>for the full web version.<br \/><\/span><\/span><\/span><\/span><\/span><\/p>\n<div style=\"text-align: left;\">\n<blockquote>\n<p><span style=\"font-size: 13px;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><\/span><\/span><\/span><\/span><\/span><\/span><em><span style=\"color: #8b8b8b;\">&#8220;Since the <\/span><a>Human Genome Project<\/a><span style=\"color: #8b8b8b;\">, we now know that<br \/>\nVitamin D is responsible for regulating over 10% of our genes.\u00a0 It&#8217;s<br \/>\nnot just responsible for skeletal health&#8211;but cells throughout the<br \/>\nentire body are dependent on Vitamin D in order to work properly.<\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\">I&#8217;m talking\u00a0 about brain function, nerve function, immune function,<br \/>\nskeletal function&#8211;all dependent on adequate supplies of Vitamin<br \/>\nD&#8211;including its important role in preventing 14 types of cancer, heart<br \/>\ndisease, autoimmune disease, diabetes, inflammation\/inflammatory<br \/>\ndiseases, infection, and osteoporosis.&#8221;<\/span><\/em><\/p>\n<div style=\"text-align: center;\"><a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2009\/12\/hollis.html\">Happy Healthy Long Life post on Dr. Bruce Hollis&#8217; Vitamin D Research<\/a>, Dec. 10, 2009<br \/><span style=\"font-size: 12px;\"><\/span><\/div>\n<\/blockquote>\n<p><strong><br \/><\/strong><\/p>\n<p><strong>It&#8217;s February!\u00a0 By this time of the year if you live in the Northern half of the U.S. most of the vitamin D you&#8217;ve stored from the sunshine is long gone and you&#8217;re at your lowest level of the year.\u00a0 You haven&#8217;t made a drop since October.\u00a0 The average American&#8217;s blood level in the winter is 15-18 ng\/mL.<\/strong><\/p>\n<p>If you read the February 1, 2010 <strong>New York Times<\/strong> article, <a href=\"http:\/\/well.blogs.nytimes.com\/2010\/02\/01\/the-miracle-of-vitamin-d-sound-science-or-hype\/\">&#8220;The Miracle of Vitamin D: Sound Science, or Hype&#8221; <\/a>you might be tempted to dismiss the recent research on Vitamin D.\u00a0 I wouldn&#8217;t advise it.\u00a0 If you want to wait to get your &#8220;sunlight fix&#8221; or down your Vitamin D supplements until the gold standard randomized control <a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2009\/06\/d-fishoil.html\">Vital Study <\/a>is complete&#8211;go for it.\u00a0 <\/p>\n<p>I wouldn&#8217;t count on its results being conclusive.\u00a0 The study group is too old-women over 65 &amp; men over 60. The dose is the same for everyone which makes no sense when it comes to vitamin D&#8211;because everyone has a different base level of vitamin D&#8211;and vitamin D doses are weight dependent.\u00a0 Plus, much of the benefit of taking vitamin D occurs years before disease may surface.<\/p>\n<p>In December 2009 I reported on Dr. Bruce Hollis&#8217; research on the effects of Vitamin D in pregnancy and breast-feeding.\u00a0 This post is the continuation of my summary of his interview with Joe and Terry Graedon on the <a href=\"http:\/\/www.peoplespharmacy.com\/2009\/11\/19\/749-vitamin-d-update\/\">People&#8217;s Pharmacy, November 19, 2009<\/a>.\u00a0 <\/p>\n<p>For my previous posts on vitamin D, click here:<\/p>\n<ul style=\"font-family: inherit;\">\n<li style=\"font-family: inherit;\"><a><\/a><a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2009\/12\/hollis.html\">Dr. Bruce Hollis&#8217; NIH Vitamin D in Pregnancy<br \/>\nStudy is Now Complete. High Dose Vitamin D (4000 IUs) Significantly<br \/>\nImproved Health &amp; Outcomes for Moms and Babies. And Harvard<br \/>\nResearchers&#8217; Theory of a Vitamin D &#8211; Autism Connection<\/a><\/li>\n<li style=\"font-family: inherit;\"><a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2009\/10\/goodbye-sun.html\">Everything You Ever Wanted to Know About<br \/>\nVitamin D from the Expert, Dr. Michael Holick. How Much Do We Need? Why<br \/>\nIs It So Hard to Get Enough? What About Breast-Fed Babies? Why Is It So<br \/>\nImportant for Good Health?<\/a><\/li>\n<li style=\"font-family: inherit;\"><a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2008\/01\/why-is-vitamin.html\">Why is Vitamin D my favorite? Let me count the reasons.<\/a><\/li>\n<li style=\"font-family: inherit;\"><a href=\"http:\/\/www.happyhealthylonglife.com\/happy_healthy_long_life\/2009\/05\/advice-from-the-coach.html\">Caroline Adams Miller&#8217;s Ten Non-Negotiable<br \/>\nPearls to a Life Well-Lived &#8211; Successful Balanced Happy. And the<br \/>\nPossible Dementia Vitamin D Connection<\/a><\/li>\n<\/ul>\n<p><strong><span style=\"color: #bf5f00;\">Who is Dr. Bruce W. Hollis?<\/span><\/strong><\/p>\n<p>He&#8217;s one of the leading authorities on vitamin D, as well as Professor of Pediatrics, Biochemistry and<br \/>\nMolecular Biology, and the Director of Pediatric Nutritional Sciences at the<br \/>\nMedical University of South Carolina in Charleston, SC.<\/p>\n<p><span style=\"color: #bf5f00;\"><strong>If this vitamin is so important, why are so many of us deficient?<\/strong><\/span><\/p>\n<p>This potent hormone is made through the skin&#8211;we were designed to get it from the sun, not through food or supplements.\u00a0 Most of us spend much of our time indoors, and when we are outside we&#8217;re covered in clothing and sunscreen.\u00a0 If you live above the 37th parallel (Richmond, VA-St. Louis, MO-Sacramento, CA) you can&#8217;t make enough vitamin D from the sun for almost 6 months out of the year!<\/p>\n<p><strong><span style=\"color: #bf5f00;\">Why are the RDIs (recommended daily intakes) for Vitamin D so low &#8211; at 200 or 400 IUs?\u00a0 Why is the normal blood level for Vitamin D set so low, at 31?<\/span><\/strong><\/p>\n<p><span style=\"color: #000000;\">According to Hollis, the federal guidelines for vitamin D&#8211;set at 200-400 IUs\/day are 100% absolutely incorrect!\u00a0 They don&#8217;t even begin to touch what we need.\u00a0 <\/span><span style=\"color: #000000;\">The 400 IU recommendation was based on the amount needed to prevent<br \/>\nrickets&#8211;based on no real data&#8211;and Hollis believes that for those recommendations to continue today, is medical malpractice.<\/span><span style=\"color: #000000;\">\u00a0 Hollis&#8217; own recent safety &amp; outcomes pregnancy study recommends 4000 IUs during pregnancy.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"color: #000000;\">We&#8217;ve known for over 30 years that<br \/>\nif you get 15 minutes of sun exposure in a bathing suit between 10 and 2<br \/>\no&#8217;clock, in the middle of the summer, your body will produce 20,000 IUs<br \/>\nof vitamin D within 24 hours.\u00a0 The body can make and release huge<br \/>\namounts of vitamin D&#8211;and yet national guidelines are still recommending only 400 IUs a day.<\/span><\/p>\n<p><span style=\"color: #000000;\">According to Hollis, most adults need 2000 IUs or more\/day, and he takes 4000 IUs.\u00a0 He monitors his blood levels with the 25-hydroxy vitamin D test, and tries to keep his levels at 50-60 ng\/mL.\u00a0 <br \/><\/span><\/p>\n<p><span style=\"color: #000000;\">4000 IUs would replete (maintain at the optimal level) almost all adults unless they were obese or had a high BMI.\u00a0 In obese patients, Hollis has even found that 10,000 IUs was not be enough to adequately raise their blood levels.\u00a0 There really is no rule of thumb for &#8220;the right dose&#8221; of vitamin D for obese individuals&#8211;you just have to monitor the blood levels and make adjustments through trial and error.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong><span style=\"color: #bf5f00;\">Why are doctors now testing for vitamin D levels?\u00a0 If 31 ng\/mL is normal, why would I want to go over that level?<\/span><\/strong><br \/><\/span><\/p>\n<p><span style=\"color: #000000;\"> <strong>The history of the 25-hydroxy-Vitamin D test.<\/strong>\u00a0 Dr. John Haddad of Washington University School of Medicine developed the first test for measuring vitamin D in the blood back in the 1960s.\u00a0 To figure out what a &#8220;normal&#8221; level of Vitamin D was&#8211;a level that prevents rickets&#8211;he measured a huge number of people, like office workers, physicians, and people of color.\u00a0 Their average blood level was 27 ng\/mL&#8211;and to prevent rickets you only needed to be above 10 ng\/mL.\u00a0 <br \/><\/span><\/p>\n<p><span style=\"color: #000000;\">Back in the 1970s, it looked like most everyone was &#8220;normal&#8221; if they were over 10 ng\/mL.\u00a0 Today, we know so much more&#8211;and rickets is the least of vitamin D deficiency diseases.\u00a0 Fortunately, Haddad also tested lifeguards&#8211;and their levels were at 50-100 ng\/mL.\u00a0 Dr. Hollis believes that those are the optimum levels for good health&#8211;the physiological level one would reach if he were fully sun-exposed.\u00a0 <br \/><\/span><\/p>\n<p><span style=\"color: #000000;\">Studies continue to show that the higher the vitamin D level, the lower the risk of diabetes, heart disease, multiple sclerosis, osteoporosis, infections, breast, prostate, and colon cancers, and rheumatoid arthritis.\u00a0 31 ng\/mL has now become the lowest normal level. <br \/><\/span><\/p>\n<p>\n\t\t<strong>Classification of 25 OH Vitamin D status:<\/strong><\/p>\n<p><strong>Insufficiency\/Moderate Deficiency: &lt; or = 30 ng\/mL<br \/>Sufficiency\/Optimal Levels: 31 to 80 ng\/mL<br \/>Toxicity: &gt; 100 ng\/mL<\/strong><span style=\"color: #000000;\"> <\/span><\/p>\n<p><strong><span style=\"color: #bf5f00;\">What have we learned from new research on Vitamin D?<\/span><\/strong><\/p>\n<p>The Human Genome Project has opened our eyes.\u00a0 10% of our genes are influenced by Vitamin D&#8211;and very few of these have to do with the skeleton or bone health.\u00a0 Important processes like cell maintenance, cancer immune function, autoimmune function, infection and inflammation control&#8211;to name a few&#8211;are all affected by our levels of vitamin D.\u00a0 <\/p>\n<p>Around 2000 research began to surface about the optimal health effects of higher blood levels of vitamin D.\u00a0 In Dr. Hollis&#8217; recent pregnancy study he found immune function improved significantly&#8211;and infection rates dropped&#8211;when vitamin D was supplemented in pregnant women to 4000 IUs.\u00a0 He saw absolutely no adverse effects at this level.<\/p>\n<p><strong><span style=\"color: #bf5f00;\">How about some examples of how vitamin D supplementation has helped people in everyday medical practices?<\/span><\/strong><span style=\"font-weight: bold;\"><\/span><strong><br \/><\/strong><\/p>\n<p><strong>An elderly home-bound population.\u00a0<\/strong> Dr. S of Getzville, NY is a geriatrician treating home-bound elderly with multiple chronic conditions.\u00a0 &#8220;The medical community doesn&#8217;t understand the physical limitations caused by vitamin D insufficiency.\u00a0 The muscle and bone pain from low vitamin D can be considerable.&#8221; <\/p>\n<p><strong>Here&#8217;s just one example of how <\/strong>i<strong>ncreasing a patient&#8217;s level of vitamin D to an &#8220;robust level&#8221; benefited one of Dr. S&#8217;s patients.<\/strong> He resolved a patient&#8217;s debilitating limb pain&#8211;which was poorly responsive to narcotics&#8211;just by increasing the patients&#8217; vitamin D to optimum levels.\u00a0 He has even helped patients who have stopped walking&#8211;when they were identified as having very low Vitamin D levels.\u00a0 <\/p>\n<p>To determine the best way to increase his patients&#8217; vitamin D levels,\u00a0 he takes into account their current level and their weight, and <strong>uses a table <\/strong>(see below) that can be found in Dr. James Dowd&#8217;s book,<a href=\"http:\/\/\"> <\/a><a href=\"http:\/\/www.thevitamindcure.com\/\">The Vitamin D Cure<\/a>.\u00a0 The table is based on the research of Dr. Michael Holick and Dr. Robert Heaney. <\/p>\n<p>For those at moderate\/average vitamin D deficiency Dr. Dowd recommends supplementing at 20 IUs\/per pound and for those at highest risk (African Americans or a BMI over 30) he recommends a vitamin D dose of 25 IUs\/pound.\u00a0 <strong>In real life:<\/strong> a 185 lb. man might supplement at 3700 IUs.\u00a0 A 300 lb. man might supplement at 7500 IUs.\u00a0 A 125 pound woman might supplement at 2500 IUs.<\/p>\n<p>According to Dr. S, this has revolutionized his practice.\u00a0 By increasing his elderly patients&#8217; levels to the &#8220;best practice robust levels&#8221; of experts like Dr. Michael Holick and Dr. Bruce Hollis, he has seen &#8220;clinically satisfying success in a practice where there isn&#8217;t a lot of success&#8221;&#8211;the chronically ill geriatric home-bound population. He sees the quality of life improve for both patients and their families, with improvements in functional mobility, walking, transfers, and mood&#8211;all without having to go to other prescription medicines.\u00a0 He has also seen improvements in chronic arthritis pain.\u00a0\u00a0 Source: <a href=\"http:\/\/www.peoplespharmacy.com\/2009\/11\/19\/749-vitamin-d-update\/\">#749 Vitamin D Update Nov. 19, 2009 People&#8217;s Pharmacy podcast<\/a><\/p>\n<div style=\"text-align: center;\"><a href=\"http:\/\/www.happyhealthylonglife.com\/.a\/6a00e54fc8012e88330128776dc5c8970c-pi\" style=\"display: inline;\"><img decoding=\"async\" alt=\"VitaminDlevels\" class=\"asset asset-image at-xid-6a00e54fc8012e88330128776dc5c8970c \" src=\"http:\/\/www.happyhealthylonglife.com\/.a\/6a00e54fc8012e88330128776dc5c8970c-400wi\" style=\"border: 3px solid black; width: 400px;\" title=\"VitaminDlevels\"><\/img><\/a> <\/div>\n<p style=\"text-align: center;\"><strong>Source: James E. Dowd, M.D. <a href=\"http:\/\/www.thevitamindcure.com\/\">The Vitamin D Cure<\/a>.\u00a0 2008<\/strong> <\/p>\n<p style=\"text-align: center;\">\n<p><strong><span style=\"color: #bf5f00;\">What&#8217;s Dr. Hollis&#8217; reaction to Dr. S&#8217;s Vitamin D experience with his elderly patients?<br \/><\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><span style=\"color: #000000;\">Hollis says he get emails and comments every week with similar positive effects of vitamin D. Resolved muscle pain, and reports of people who couldn&#8217;t walk, or had to use a walker, and once they were put on adequate vitamin D they were able to walk.\u00a0 (<em>my comment<\/em>: this sounds almost like a faith-healing story&#8211;but who knows?)\u00a0 For Hollis, results such as Dr. S&#8217;s are not uncommon.\u00a0 <br \/><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"color: #000000;\"><strong>As for a vitamin D\/mood connection<\/strong>&#8211;Hollis says there&#8217;s some evidence to suggest it&#8217;s possible.\u00a0 There are vitamin D receptors in the brain and enzymes that metabolize vitamin D in the brain.\u00a0 Vitamin D definitely has neuro-functions, and Australian researchers studying its effect on rodents know that offspring born from vitamin D deficient mothers have dramatic brain deficits that are both physical and biochemical&#8211;and these deficits are never resolved.\u00a0 To Hollis this is a very scary prospect&#8211;thinking about\u00a0 humans raised in a vitamin-D deficient environment.\u00a0 He wonders about the potential for profound brain development deficits?\u00a0<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"color: #000000;\"><strong><span style=\"color: #bf5f00;\">What about vitamin D toxicity?<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"color: #000000;\"><span style=\"color: #000000;\">Normal blood levels are 31ng\/mL (lowest acceptable level) to 100 ng\/mL.\u00a0 The optimum level would be 50-70 or 80 ng\/mL, or whatever your physiological maximum level would be if you were fully sun-exposed&#8211;as are field workers or life guards.\u00a0 Hollis says he doesn&#8217;t even know what vitamin D toxicity is&#8211;he&#8217;s never seen it, and never saw any adverse effects in his pregnancy study where women took 4000 IUs\/day.\u00a0 According to Hollis, there&#8217;s little evidence of adverse effect under 10,000 IUs a day.<br \/><\/span><\/span><\/p>\n<p><strong><span style=\"color: #bf5f00;\">What about the effect of Vitamin D on rheumatoid arthritis?<\/span><\/strong><\/p>\n<p style=\"text-align: left;\">Since vitamin D is an immune regulator, and has a profound influence on autoimmune processes, it may be possible to see improvements in rheumatoid arthritis and a slowing of disease progression.\u00a0 However, vitamin D deficiency is more likely a trigger in developing autoimmune diseases like RA&#8211;not a cure for the disease. <\/p>\n<p style=\"text-align: left;\">The <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14730601\">Iowa Women&#8217;s Health Study<\/a> found women taking vitamin D supplements were less likely to develop RA.\u00a0 And in a <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20033415?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&amp;ordinalpos=2\">recent article <\/a>a surprisingly high incidence of vitamin D deficiency was found in inflammatory joint patients even in a sunny Mediterranean country. Animal studies have shown reduced joint inflammation with vitamin D supplementation. <\/p>\n<p style=\"text-align: left;\">There are just a few clinical studies on vitamin D for treatment of RA&#8211;but in 3 of 5 studies researchers saw improvements in symptoms.<\/p>\n<p><strong><span style=\"color: #bf5f00;\">Vitamin D and osteoarthritis<\/span><\/strong><\/p>\n<p style=\"text-align: left;\">From Dr. James E. Dowd of <strong>The Vitamin D Cure<\/strong>: &#8220;The Framingham Study found a 2-3 fold faster rate of osteoarthritis progression in people who were in the lowest 20% of vitamin D levels compared to those in the highest.&#8221;\u00a0 Boston researchers found that when vitamin D levels rise, people with osteoarthritis function better, and the severity of symptoms and disability are reduced.\u00a0 <\/p>\n<p style=\"text-align: left;\">Non-specific aches &amp; pains in bones and muscles can be confused with osteoarthritis or fibromyalgia&#8211;but if it&#8217;s\u00a0 caused by osteomalacia it will improve dramatically (may take 3-6 months) with adequate vitamin D.<\/p>\n<p style=\"text-align: left;\"><strong><span style=\"color: #bf5f00;\">Can adequate levels of Vitamin D really prevent colds &amp; the flu?<\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><strong>The higher the vitamin D level the lower the risk of upper respiratory tract infections.<\/strong>\u00a0 According to Hollis there are ongoing studies on using vitamin D as an immune booster, and there is incredible evidence to show just how this works.\u00a0 <\/p>\n<p style=\"text-align: left;\">Vitamin D activates the &#8220;Rapid Response&#8221; component of our immune system, called the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Innate_immune_system\">innate immune system<\/a> which\u00a0 controls the production of natural &#8220;antibiotics&#8221; that attract bacteria &amp; viruses.\u00a0 These processes aren&#8217;t activated if someone is vitamin D deficient.\u00a0 And Hollis&#8217; pregnancy study offered conclusive proof that increasing levels of vitamin D absolutely controlled infection.\u00a0 &#8220;The vitamin D\u00a0 immune boost is a very real thing!&#8221;<\/p>\n<p><strong><span style=\"color: #bf5f00;\">What about the cancer connection? It seems so far-fetched.<\/span><\/strong><\/p>\n<p style=\"text-align: left;\">Dr. Hollis has collaborated with Dr. Walter Willett and the Harvard School of Public Health for over 15 years, studying epidemiologic data on the effects of vitamin D on cancer.\u00a0 These studies have routinely shown that an adequate vitamin D status protects against 13 or 14 different cancers, including breast, prostate, and colon cancer.\u00a0 <\/p>\n<p style=\"text-align: left;\">Hollis is skeptical that vitamin D could treat cancer once you get it&#8211;its benefit is in preventing it in the first place&#8211;and having adequate levels will lower your risk.\u00a0 Researchers in <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17867379?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&amp;ordinalpos=13\">Nutrition Reviews<\/a> project that a vitamin D blood level over 52 ng\/mL would reduce breast cancer by 50%, and levels over 34 ng\/mL would prevent 50% of the colon cancers.<\/p>\n<p style=\"text-align: left;\"><strong>Here&#8217;s how it works<\/strong>: Vitamin D helps control cell growth and that&#8217;s why we think that it<br \/>\nwill reduce the risk of many deadly cancers like prostate, breast, and<br \/>\ncolon by as much as 50 percent.\u00a0 In its role as a hormone, vitamin D travels all over our body<br \/>\ndelivering messages to activate genes and control cell growth.\u00a0 <\/p>\n<p style=\"text-align: left;\">If a<br \/>\ncell turns cancerous, vitamin D delivers the instructions for that cell<br \/>\nto self-destruct. Not enough vitamin D and that cancer cell might keep<br \/>\nreproducing.\u00a0 According to Hollis,\u00a0 &#8220;vitamin D acts as a brake&#8221; when it comes to cancer.\u00a0 It prevents cells from growing wildly out-of-control&#8211;and this mechanism has been studied for years.<\/p>\n<p style=\"text-align: left;\"><strong><span style=\"color: #bf5f00;\">Explain the difference between D2 and D3.\u00a0 Is D3 superior?<\/span><\/strong><\/p>\n<p style=\"text-align: left;\">D2 was commonly used in the U.S. because it was approved as a pharmaceutical in 1911.\u00a0 But Hollis doesn&#8217;t like to use it.\u00a0 It&#8217;s unnatural.\u00a0 It comes from yeast.\u00a0 It&#8217;s functional, but D3 is preferable, and it&#8217;s very easy to get these days.\u00a0 If you have the option&#8211;Hollis says, &#8220;Use D3&#8221;.<\/p>\n<p style=\"text-align: left;\"><strong><span style=\"color: #bf5f00;\">How do you get enough vitamin D if you have a severe malabsorption syndrome, colitis or celiac disease?<\/span><\/strong><\/p>\n<\/p>\n<p>If you can&#8217;t absorb vitamin D supplements adequately, you clearly need to get your vitamin D from the sun.\u00a0 There are no vitamin D injections. When it comes to winter-time, dermatologists won&#8217;t approve, but one option is short twice weekly visits to a sun tanning bed&#8211;10-15 minutes with face &amp; neck covered with sunscreen.\u00a0 It is effective.\u00a0 Or play it safe and find out about getting controlled UV treatments in a medical setting.<\/p>\n<p><strong><span style=\"color: #bf5f00;\">What are normal vitamin D blood levels for children?<\/span><\/strong><\/p>\n<p>Hollis says normal levels for children are the same as for adults.\u00a0 &#8220;Do you think a rapidly growing child needs less vitamin D than a staid (no-longer-growing) adult?&#8221;\u00a0 A colleague of Hollis&#8217; in S. Africa recently measured blood levels of active-outdoor-playing children, both Black and Caucasian.\u00a0 Both had similar levels&#8211;around 50 ng\/mL.<\/p>\n<p><strong><span style=\"color: #bf5f00;\">Please explain how vitamin D affects cardiovascular health.<\/span><\/strong><\/p>\n<p><strong>There is a 142% increased risk of heart attack in vitamin D levels under 15ng\/mL.<\/strong>\u00a0 According to Hollis, important recent research has shown that vitamin D acts as a natural statin, by decreasing inflammation.\u00a0 It doesn&#8217;t lower cholesterol.\u00a0 It also prevents the infection-inflammatory processes and lowers blood pressure&#8211;both of which can contribute to damaged blood vessels, atherosclerotic plaque build-up, and clot formation.<\/p>\n<p><strong><span style=\"color: #bf5f00;\">Once you start taking vitamin D supplements how long will it take to increase your blood levels?<br \/><\/span><\/strong><\/p>\n<p>Hollis said most physicians should assume that their patients are vitamin D deficient, especially every person of color,\u00a0 and order a base-line blood level test&#8211;the 25-hydroxy-vitamin D test.\u00a0 For most people, supplementing with 2000-4000 IUs of vitamin D should be adequate.\u00a0 1000 IUs will do very little except for a small child. <\/p>\n<p>You&#8217;ll need to wait 3 months before getting retested.\u00a0 If someone is very low, and depending upon their size, it could take months to get their levels up to optimal&#8211;50 ng\/mL-70mg\/mL.\u00a0\u00a0<\/p>\n<p><strong><span style=\"color: #bf5f00;\">What research on the horizon looks the most exciting?<\/span><\/strong><\/p>\n<p>Hollis is most excited about the current research on the effect of vitamin D on infections, as well as the multiple sclerosis\/vitamin D research of Dr. George Ebers of Oxford University.\u00a0 Ebers recently discovered that vitamin D deficiency is an environmental trigger for multiple sclerosis.\u00a0 <\/p>\n<p>&#8220;<span style=\"font-size: 13px;\">The Oxford University-led research, published in <strong>PLoS Genetics<\/strong>,<br \/>\nsuggests that vitamin D deficiency during pregnancy and the early years<br \/>\nmay increase the risk of offspring developing MS later in life.&#8221; <a href=\"http:\/\/www.ox.ac.uk\/media\/news_stories\/2009\/100209_2.html\">Click here<\/a> to read more.<\/span><\/p>\n<p><span style=\"font-size: 13px;\"><strong><span style=\"color: #bf5f00;\">How about some &#8220;practice-based evidence&#8221; from primary care or internal medicine physicians?<br \/><\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 13px;\">Two comments from physicians in response to the Feb. 1, 2010 <strong>New York Times<\/strong> <a href=\"http:\/\/well.blogs.nytimes.com\/2010\/02\/01\/the-miracle-of-vitamin-d-sound-science-or-hype\/\">Vitamin D article<\/a> were of particular interest to me.<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 13px;\"><strong><span style=\"color: #bf5f00;\">Dr. Robert Baker<\/span><\/strong>\u00a0 <br \/><\/span><\/p>\n<blockquote>\n<p><em><span style=\"color: #8b8b8b;\">\u00a0&#8220;The major problem with the proposed study is that it will give 2000<br \/>\nunits of vitamin D a day without testing levels to determine an end<br \/>\npoint. 400 Units daily has been shown to raise levels only 5 ng., and<br \/>\n2000 Units daily has been shown in some studies to raise levels less<br \/>\nthan 20 ng. <\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\">I have tested 1800 people in primary care practice since 2005.<br \/>\n2\/3rds are below 32 ng. but 1\/3rd are below 20 ng., and 10% have levels<br \/>\nin single digits. These figures are duplicated with published studies.<br \/>\nSo for many people raising the level even 20 ng. will not be enough.<\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\"><\/span><span style=\"color: #8b8b8b;\"> The human body from sun alone will not make a level over 150 ng. A<br \/>\nfeedback mechanism breaks down vitamin D in the skin once this level is<br \/>\nreached. <br \/><\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\">Lifeguards in August have been shown to have levels<br \/>\napproaching this level. Humans evolving near the equator wearing scant<br \/>\nclothing would also have had this level. <br \/><\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\">Sufficient vitamin D does not<br \/>\ncome from diet &#8211; amounts are small and several glasses of milk only<br \/>\nhave the small amount of 400 units of vitamin D because manufacturers<br \/>\nadd it.<\/span><span style=\"color: #8b8b8b;\"> <br \/><\/span><\/em><\/p>\n<p><em><span style=\"color: #8b8b8b;\">So the wisdom of nature is already telling us the maximum level.<\/span><\/em><span style=\"color: #8b8b8b;\"><em>&#8220;<\/em>\u00a0 <a href=\"http:\/\/well.blogs.nytimes.com\/2010\/02\/01\/the-miracle-of-vitamin-d-sound-science-or-hype\/?apage=3#comment-473091\">Click here <\/a>for the NYT link<br \/><\/span><\/p>\n<p>Robert Baker MD<br \/>\n Primary Care Internal Medicine<br \/>\n Cherry Hill, NJ<br \/>\n <a href=\"mailto:rcbaker200@comcast.net\">rcbaker200@comcast.net<\/a><\/p>\n<div class=\"comment-content\">\n<div style=\"text-align: center;\">\n<p><strong><span style=\"color: #bf5f00;\"><br \/><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: #bf5f00;\">Dr. Greg Plotnikoff<\/span><\/strong><\/p>\n<\/div>\n<p><a href=\"http:\/\/\"><br \/><\/a><a href=\"http:\/\/well.blogs.nytimes.com\/2010\/02\/01\/the-miracle-of-vitamin-d-sound-science-or-hype\/?apage=3#comment-473105\">Vitamin D and Pain<\/a><\/p>\n<p>Most clinicians who have read the literature and who prescribe<br \/>\nvitamin D for patients based on their blood tests will affirm that<br \/>\nreplenishing vitamin D to a serum level of greater than 40 ng\/ml can<br \/>\nmake a huge difference in chronic pain, muscular weakness and a wide<br \/>\nrange of non-specifc complaints. <\/p>\n<p>The most impressive reports come from woman with muscle or bone pain<br \/>\non an aromatase inhibitor or persons with undiagnosed, chronic,<br \/>\nnon-specific musculoskeletal pain or unexplained significant muscular<br \/>\nweakness.<\/p>\n<p>No one with symptoms has fibromylagia or somatoform disorder until vitamin D deficiency has been ruled out or replenished.<\/p>\n<p>Testing and replenishment is incredibly cost-effective.<\/p>\n<p>The clinical effectiveness of D replenishment can be so profound, so<br \/>\nunforgettable, that for practicing physicians there is no need for<br \/>\nrandomized controlled trials to assess the value of normalizing low<br \/>\nvitamin D in persons who suffer.<\/p>\n<p>Simply, test, replenish, monitor. <\/p>\n<p>Why wait five years for a publication when one can have results of a<br \/>\nblood test in a few days and results of replenishment in 2-6 months?<\/p>\n<p>Asking this crucial question frustrates well-meaning researchers: Failing to ask this question frustrates patients.<\/p>\n<p> <cite>\u2014 Greg Plotnikoff, MD<\/cite>\n <\/div>\n<p><span style=\"color: #8b8b8b;\"><\/span><\/p>\n<\/blockquote>\n<ul>\n<\/ul>\n<p><\/p>\n<p><span style=\"font-size: 13px;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px; color: #bf5f00;\"><span style=\"font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><span style=\"color: #bf5f00; font-size: 11px;\"><\/span><\/span><\/span><\/span><\/span><\/span><\/div>\n<div style=\"text-align: left;\"><span style=\"color: #000000; font-size: 13px;\"><br \/>\n<\/span><\/div>\n<\/div>\n<\/div>\n<div class=\"feedflare\">\n<a href=\"http:\/\/feeds.feedburner.com\/~ff\/typepad\/happyhealthylonglife\/happy_healthy_long_life?a=UoOmYwzDsoo:_upNhBABUT0:yIl2AUoC8zA\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/typepad\/happyhealthylonglife\/happy_healthy_long_life?d=yIl2AUoC8zA\" border=\"0\"><\/img><\/a>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/typepad\/happyhealthylonglife\/happy_healthy_long_life\/~4\/UoOmYwzDsoo\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Target tissues for Vitamin D&#8211;Curr Opin Clin Nutr Metab Care 10:12-19, 2007 If you are receiving this via email click here for the full web version. &#8220;Since the Human Genome Project, we now know that Vitamin D is responsible for regulating over 10% of our genes.\u00a0 It&#8217;s not just responsible for skeletal health&#8211;but cells throughout [&hellip;]<\/p>\n","protected":false},"author":2896,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-290735","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/290735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/2896"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=290735"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/290735\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=290735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=290735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=290735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}