{"id":297715,"date":"2010-02-09T08:47:29","date_gmt":"2010-02-09T13:47:29","guid":{"rendered":"http:\/\/blogs.wsj.com\/health\/2010\/02\/09\/cholesterol-drug-approved-for-people-without-high-cholesterol\/"},"modified":"2010-02-09T08:47:29","modified_gmt":"2010-02-09T13:47:29","slug":"cholesterol-drug-approved-for-people-without-high-cholesterol","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/297715","title":{"rendered":"Cholesterol Drug Approved for People Without High Cholesterol"},"content":{"rendered":"<p><img decoding=\"async\" src=\"http:\/\/s.wsj.net\/media\/heart_art_200_20071214093616.jpg\" alt=\"Heart\" align=\"right\"\/>Statins&#8217; global conquest continues. The class of cholesterol drugs already includes Pfizer&#8217;s megablockbuster Lipitor as well as simvastatin, the hugely popular generic that Merck sold under the brand name Zocor.<\/p>\n<p>Now, AstraZeneca&#8217;s statin Crestor has crossed a new threshold: It&#8217;s the cholesterol drug for people who don&#8217;t have high cholesterol.<\/p>\n<p>The FDA just expanded the drug&#8217;s <a href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm199891.htm\" >approval<\/a> to include reducing the risk of heart attack and stroke in people who meet all of the following criteria:<\/p>\n<ul>\n<li>Older than 50 for men, older than 60 for women\n<\/li>\n<li>Elevated high-sensitivity C-reactive protein level (we&#8217;ll explain this one in a minute)\n<\/li>\n<li>At least one additional cardiovascular risk factor (such as high blood pressure, smoking, or a family history early heart disease)\n<\/li>\n<\/ul>\n<p>The approval is based on a big study called <a href=\"http:\/\/clinicaltrials.gov\/show\/NCT00239681\" >Jupiter<\/a>, which found that the drug reduced the risk of serious heart problems in patients with normal cholesterol but high levels of something called <a href=\"http:\/\/www.americanheart.org\/presenter.jhtml?identifier=4648\" >C-reactive protein<\/a>.<\/p>\n<p>CRP is a marker of inflammation. As we&#8217;ve <a href=\"http:\/\/blogs.wsj.com\/health\/2009\/06\/30\/study-c-reactive-protein-doesnt-cause-heart-disease\/\" >noted before<\/a>, it hasn&#8217;t joined measures such as blood pressure and cholesterol as a reliable measure of cardiovascular risk. <\/p>\n<p>So whether Crestor&#8217;s new indication leads to broader use of the drug will depend in part on how often doctors measure their patients&#8217; CRP levels, and how often they act on what they find.<\/p>\n<p>Photo by <a href=\"http:\/\/www.flickr.com\/photos\/carbonnyc\/132922595\/\" >CarbonNYC<\/a> via Flickr<\/p>\n<p><a href=\"http:\/\/feedads.g.doubleclick.net\/~at\/5hCjsm0az1mH71A1G-K3kQWlgdc\/0\/da\"><img decoding=\"async\" src=\"http:\/\/feedads.g.doubleclick.net\/~at\/5hCjsm0az1mH71A1G-K3kQWlgdc\/0\/di\" border=\"0\" ismap=\"true\"><\/img><\/a><br \/>\n<a href=\"http:\/\/feedads.g.doubleclick.net\/~at\/5hCjsm0az1mH71A1G-K3kQWlgdc\/1\/da\"><img decoding=\"async\" src=\"http:\/\/feedads.g.doubleclick.net\/~at\/5hCjsm0az1mH71A1G-K3kQWlgdc\/1\/di\" border=\"0\" ismap=\"true\"><\/img><\/a><\/p>\n<div class=\"feedflare\">\n<a href=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?a=C6CDmiaqh-M:9zWJ78Ddxxs:yIl2AUoC8zA\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?d=yIl2AUoC8zA\" border=\"0\"><\/img><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?a=C6CDmiaqh-M:9zWJ78Ddxxs:D7DqB2pKExk\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?i=C6CDmiaqh-M:9zWJ78Ddxxs:D7DqB2pKExk\" border=\"0\"><\/img><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?a=C6CDmiaqh-M:9zWJ78Ddxxs:F7zBnMyn0Lo\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?i=C6CDmiaqh-M:9zWJ78Ddxxs:F7zBnMyn0Lo\" border=\"0\"><\/img><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?a=C6CDmiaqh-M:9zWJ78Ddxxs:V_sGLiPBpWU\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?i=C6CDmiaqh-M:9zWJ78Ddxxs:V_sGLiPBpWU\" border=\"0\"><\/img><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?a=C6CDmiaqh-M:9zWJ78Ddxxs:qj6IDK7rITs\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/wsj\/health\/feed?d=qj6IDK7rITs\" border=\"0\"><\/img><\/a>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/wsj\/health\/feed\/~4\/C6CDmiaqh-M\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Statins&#8217; global conquest continues. The class of cholesterol drugs already includes Pfizer&#8217;s megablockbuster Lipitor as well as simvastatin, the hugely popular generic that Merck sold under the brand name Zocor. Now, AstraZeneca&#8217;s statin Crestor has crossed a new threshold: It&#8217;s the cholesterol drug for people who don&#8217;t have high cholesterol. The FDA just expanded the [&hellip;]<\/p>\n","protected":false},"author":650,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-297715","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/297715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/650"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=297715"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/297715\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=297715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=297715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=297715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}