{"id":361911,"date":"2010-02-25T10:01:44","date_gmt":"2010-02-25T15:01:44","guid":{"rendered":"http:\/\/childrenshospitalblog.org\/?p=5212"},"modified":"2010-02-25T10:01:44","modified_gmt":"2010-02-25T15:01:44","slug":"stem-cells-open-a-window-on-aging-cancer-and-a-devastating-disease","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/361911","title":{"rendered":"Stem cells open a window on aging, cancer and a devastating disease"},"content":{"rendered":"<\/p>\n
\n\t\"This<\/p>\n

This image shows the green fluorescent signal from telomeres, bits of DNA at the tips of chromosomes (shown in blue). The intensity of the green signal is one indicator of telomere length, which is a measure of cellular "aging" and determines how many times a cell can divide.<\/p>\n<\/div>\n

Stem cell research is in its infancy, but a new study led by Children\u2019s Suneet Agarwal, MD, PhD, and George Q. Daley, MD, PhD, investigators in Children’s Stem Cell Transplantation Program, reveal these cells\u2019 unique powers to teach us about devastating, hard-to-treat diseases \u2013 and, in this case, cancer and aging.<\/p>\n

In Children with dyskeratosis congenita, a rare condition that leads to premature aging, genetic mutations impair a key enzyme called telomerase that builds up the tips of our chromosomes, known as telomeres. When cells aren\u2019t able to maintain their telomeres, the chromosomes become vulnerable to all kinds of damage, and the cell \u201cages\u201d more quickly and stops dividing. As a result, children with dyskeratosis congenita have bone marrow failure<\/a> \u2013 they\u2019re unable to make enough blood cells to sustain the body. This requires a bone marrow transplant \u2013 an especially punishing procedure for these children, whose other tissues and organs are also failing because of the disease.<\/span><\/p>\n

Wanting to better understand this condition, Agarwal and Daley took skin cells from three patients. In the lab, they introduced four genes to transform the cells into pluripotent stem cells (iPS cells) \u2013 cells closely resembling embryonic stem cells. Their intention was to manipulate these iPS cells to see how dyskeratosis congenita develops at the cellular level. But to their surprise, the very process of creating the iPS cells actually reactivated telomerase, allowing telomeres to be maintained — and potentially correcting the disease.<\/p>\n

The findings<\/a>, reported by Reuters<\/a>, Technology Review<\/a> and USA Today<\/a>, have great implications for understanding stem cells, aging and cancer and the relationships between them. For children with dyskeratosis congenita, the findings also offer the hope of developing drugs to help them build up their telomeres. Also, there\u2019s the potential to make iPS cells from these patients, and use them to make a supply of genetically-matched blood cells \u2013 providing a safer form of bone marrow transplant.<\/p>\n

Children\u2019s is very excited about the potential of iPS cells and other kinds of pluripotent stem cells to develop new treatments for diseases both rare and common. Keep an eye on Thrive for much more about them.<\/p>\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

This image shows the green fluorescent signal from telomeres, bits of DNA at the tips of chromosomes (shown in blue). The intensity of the green signal is one indicator of telomere length, which is a measure of cellular "aging" and determines how many times a cell can divide. Stem cell research is in its infancy, […]<\/p>\n","protected":false},"author":479,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-361911","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/361911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/479"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=361911"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/361911\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=361911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=361911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=361911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}