{"id":440710,"date":"2010-03-17T18:31:00","date_gmt":"2010-03-17T22:31:00","guid":{"rendered":"tag:blogger.com,1999:blog-18884161.post-7788108372697461018"},"modified":"2010-03-17T18:38:02","modified_gmt":"2010-03-17T22:38:02","slug":"natural-gmos-part-62-chromosomes-move-around-the-molds","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/440710","title":{"rendered":"Natural GMOs Part 62. Chromosomes move around the molds."},"content":{"rendered":"<p><b>Comparative genomics reveals mobile pathogenicity chromosomes in <i>Fusarium&nbsp;<\/i><\/b><\/p>\n<p>Li-Jun Ma, H. Charlotte van der Does, Katherine A. Borkovich, and many others<br \/>Nature Vol 464| 18 March 2010| doi:10.1038\/nature08850<\/p>\n<p><i>Fusarium<\/i> species are among the most important phytopathogenic and toxigenic fungi.<br \/>&nbsp;To understand the&nbsp;molecular&nbsp;underpinnings of pathogenicity in the genus <i>Fusarium,<\/i> we compared the genomes of three phenotypically diverse species:<br \/><i>Fusarium graminearum, Fusarium verticillioide<\/i>s and <i>Fusarium oxysporum<\/i> f. sp. <i>lycopersici<\/i>.<\/p>\n<p><a name='more'><\/a>Our analysis revealed&nbsp;lineage-specific (LS) genomic regions in <i>F. oxysporum<\/i> that include four entire chromosomes and account for more than&nbsp;one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to&nbsp;pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes&nbsp;between strains of <i>F. oxysporum<\/i>, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between&nbsp;otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new&nbsp;pathogenic lineages in <i>F. oxysporum<\/i>. These findings put the evolution of fungal pathogenicity into a new perspective.<\/p>\n<div class=\"blogger-post-footer\"><img width='1' height='1' src='https:\/\/blogger.googleusercontent.com\/tracker\/18884161-7788108372697461018?l=gmopundit.blogspot.com' alt='' \/><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium&nbsp; Li-Jun Ma, H. Charlotte van der Does, Katherine A. Borkovich, and many othersNature Vol 464| 18 March 2010| doi:10.1038\/nature08850 Fusarium species are among the most important phytopathogenic and toxigenic fungi.&nbsp;To understand the&nbsp;molecular&nbsp;underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species:Fusarium [&hellip;]<\/p>\n","protected":false},"author":710,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-440710","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/440710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/710"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=440710"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/440710\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=440710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=440710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=440710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}