{"id":538671,"date":"2010-04-21T15:23:19","date_gmt":"2010-04-21T19:23:19","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/80beats\/?p=13794"},"modified":"2010-04-21T15:23:19","modified_gmt":"2010-04-21T19:23:19","slug":"a-life-extending-coup-flies-that-can%e2%80%99t-smell-food-live-30-percent-longer-80beats","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/538671","title":{"rendered":"A Life-Extending Coup: Flies That Can\u2019t Smell Food Live 30 Percent Longer | 80beats"},"content":{"rendered":"

\"sn-aging-thumb-200xauto-306\"In today’s edition of far-out science, researchers have found evidence that the wafting aroma of food has an effect on an organism’s lifespan–and they’ve demonstrated that interfering with a fruit fly’s sense of smell causes it to live a longer, healthier life. While there’s no guarantee that the trick would work for humans, optimistic researchers suggest that certain odors\u2014or drugs that block us from sensing them\u2014might one day help prevent disease and extend lives [ScienceNOW<\/em><\/a>].<\/span><\/p>\n

In the past decade, scientists have established a clear connection between extremely low-calorie diets and extended lifespans; studies have demonstrated that yeast, fruit flies, mice<\/a>, and monkeys<\/a> on these diets live longer than their peers. While the exact mechanism at work isn’t yet clear, researchers suspect that a near-starvation diet causes an organism’s metabolism to slow down, and triggers other changes that evolved to help organisms survive in times when food was scarce. Now scientists say it may not be just what a creature eats, but also what it smells that has an effect on how long it lives.<\/p>\n

In one 2007 study<\/a>, molecular biologist Scott Pletcher and his colleagues found that completely eliminating fruit flies’ sense of smell caused them to live nearly 20 percent longer than normal flies. They also found<\/a> that wafting the smell of yeast, a tasty treat for fruit flies, towards flies that were on a low-cal, live-extending diet hastened the death of those flies. This led the scientist to hypothesize that specific odors might be influencing the flies\u2019 lifespans. Luckily, other scientists had identified a receptor in a group of neurons that enable fruit flies to smell carbon dioxide, which signals the presence of a good meal of tasty yeast <\/span>[ScienceNOW<\/em><\/a>]<\/span>.<\/span> So,\u00a0Pletcher and his team set out to find if the CO2 had anything to do with the duration of the flies’ lives.<\/p>\n

<\/span>For the new study published<\/a> in PloS Biology, <\/em>Pletcher eliminated the fruit flies\u2019 ability to smell carbon dioxide, while keeping the rest of the olfactory system intact. <\/span>Even on a standard, full-calorie diet, the flies that couldn’t detect CO2 lived up to 30 percent longer than other flies. The researchers suggest that the absense of CO2 may have indicated to the altered flies that food was scarce in the environment, prompting them to snap into survival mode. Oddly, however, the life-extending effect was only seen in female flies–male flies gained no such benefit. The smell-deprived female flies also seemed healthier and stronger by several measures: They stored extra fat, produced more offspring, and proved to be more resistant to oxidative stress than normal flies.<\/p>\n

Pletcher isn\u2019t sure how the inability to smell CO2 extended the females\u2019 lifespans, but he says the findings open up fascinating new areas for studies of human aging. He suggests that there might be certain smells or drugs that would block certain odors, and which could give humans a bit more time before we shuffle off our mortal coils. Matt Karberlein, an aging expert who wasn’t involved in Pletcher’s research, was cautiously optimistic about that possibility, saying: \u201cWe definitely undergo physiological changes in response to smelling food \u2013 I\u2019m getting hungry just thinking about it \u2013 so I think it\u2019s possible\u201d [New Scientist<\/em><\/a>].<\/span><\/p>\n

Related Content:<\/span>
\n80beats: A Single Genetic Tweak Gives Mice Longer, Healthier Lives<\/a>
\n80beats: Low-Calorie Diet Staves off Aging & Death in Monkeys<\/a>
\nNot Exactly Rocket Science: <\/a>Low-calorie diets improve memory in old age<\/a>
\nDISCOVER: In Worms, a New Theory on Aging<\/a><\/p>\n

Image: Scott Pletcher \/ University of Michigan, Ann Arbor<\/em><\/span>
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In today’s edition of far-out science, researchers have found evidence that the wafting aroma of food has an effect on an organism’s lifespan–and they’ve demonstrated that interfering with a fruit fly’s sense of smell causes it to live a longer, healthier life. While there’s no guarantee that the trick would work for humans, optimistic researchers […]<\/p>\n","protected":false},"author":641,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-538671","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/538671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/641"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=538671"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/538671\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=538671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=538671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=538671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}