{"id":642739,"date":"2013-02-15T14:52:50","date_gmt":"2013-02-15T19:52:50","guid":{"rendered":"http:\/\/gigaom.com\/?p=611255"},"modified":"2013-02-15T14:52:50","modified_gmt":"2013-02-15T19:52:50","slug":"as-genome-sequencing-becomes-more-affordable-should-you-do-it","status":"publish","type":"post","link":"https:\/\/mereja.media\/index\/642739","title":{"rendered":"As genome sequencing becomes more affordable should you do it?"},"content":{"rendered":"<p>Genome sequencing is becoming more affordable than ever before \u2013 several companies in the industry say the <a href=\"http:\/\/www.fastcompany.com\/1839134\/age-1000-genome\">$1,000 personal genome <\/a>is just around the corner. But, even if you can afford it, is mapping your genes worth it if you don\u2019t have a specific medical condition to consider?<\/p>\n<p>Despite the whole &#8220;knowledge is power&#8221; argument \u2013 it could help with early diagnosis and prevention or lead a doctor to better treatment options for an existing condition \u2013 sequencing skeptics raise valid concerns and questions when it comes to gene sequencing for healthy people. How precise is it? How well will consumers be able to interpret the results? Will it just lead to needless hand-wringing about conditions that people won\u2019t be able to do to much to address or that won\u2019t surface until much later in life?<\/p>\n<p>For now, those are questions for people with only the deepest pockets. But it won\u2019t be long before the conversation becomes more relevant for more of us and, in the <i><a href=\"http:\/\/online.wsj.com\/article\/SB10000872396390443884104577645783975993656.html\">Wall Street Journal<\/a><\/i> this week, two doctors weigh in with the pros and cons of the debate over whether healthy people should have their genomes sequenced.<\/p>\n<p>Dr. Atul J. Butte, division chief and associate professor at the Stanford University School of Medicine and director of the Center for Pediatric Bioinformatics at Lucile Packard Children&#8217;s Hospital in Palo Alto, Calif., takes the pro position. And Dr. Robert Green, a medical geneticist at Brigham and Women&#8217;s Hospital and Harvard Medical School in Boston, argues against it.<\/p>\n<p>Even though Dr. Butte acknowledges that gene sequencing isn\u2019t perfect, he believes the positives outweigh the negatives. He says:<\/p>\n<ul>\n<li>Identifying DNA variants that are early indicators of disease can lead to early diagnoses and preventative strategies.<\/li>\n<li>Couples planning families can learn whether they carry genetic risks for serious disorders.<\/li>\n<li>Doctors can better figure out the most effective drugs for a patient or what to avoid<\/li>\n<li>It can help in the diagnosis of illnesses that haven\u2019t yet been identified.<\/li>\n<\/ul>\n<p>On the flip side, Dr. Green believes that while affordable genomic analysis opens the door to personalized disease prevention and treatment options, there are still roadblocks. For example:<\/p>\n<ul>\n<li>Medically dangerous gene mutations are rare in healthy individuals but it would still be very expensive to find them \u2013 less than 2 percent of healthy people have a dangerous DNA mutation that would spur a doctor to monitoring or treatment. Assuming sequencing costs $5,000 now, it could cost $250,000 to find one person with a mutation.<\/li>\n<li>Known mutations may or may not carry the same risk without a family history, so sequencing alone can\u2019t always lead to action.<\/li>\n<li>Geneticists don\u2019t always agree on whether gene mutations are dangerous.<\/li>\n<\/ul>\n<p>When it comes to health, I tend to fall on the side of information \u2013 the more of it we have, the better off we are. And the rise of consumer-ready medical technology that gives us clearer windows into our bodies \u2013 from <a href=\"http:\/\/www.fitbits.com\/\">Fitbits<\/a> (see disclosure) to the <a href=\"http:\/\/www.alivecor.com\/\">AliveCor<\/a> iPhone-compatible <a href=\"http:\/\/gigaom.com\/2012\/12\/03\/alivecors-ekg-monitoring-case-for-iphone-gets-fda-approval\/\">heart monitor<\/a> \u2013 is setting the stage for an era in which people are armed with even more data about their health. <a href=\"http:\/\/www.23andme.com\/\">23andme<\/a>\u00a0doesn&#8217;t do full gene sequencing but its genotyping services already let people explore their DNA for just $99.<\/p>\n<p>But as we move into this new bioinformation-filled future, it&#8217;s important to keep the skeptic&#8217;s voices in mind because gene sequencing doesn&#8217;t just have personal implications but public health consequences. One of Dr. Green&#8217;s most haunting concerns is the rise of &#8220;patients in waiting&#8221; who spend their lives in anxiety, undergoing unnecessary tests and potentially doing themselves more harm than good. But as\u00a0<a href=\"http:\/\/healthland.time.com\/2012\/10\/26\/why-cheaper-genetic-testing-could-cost-us-a-fortune\/\">others have noted<\/a>, sequencing could take its toll on the health care system with unessential screenings and procedure, tax the patient-doctor relationship and lead to <a href=\"http:\/\/www.nytimes.com\/2012\/08\/26\/health\/research\/with-rise-of-gene-sequencing-ethical-puzzles.html?pagewanted=all\">other biotethical questions<\/a>.<\/p>\n<p><em><strong>Disclosure:<\/strong> True Ventures is an investor in Fitbit and the parent company of this blog, Giga Omni Media. Om Malik, founder of Giga Omni Media, is also a venture partner at True.<\/em><\/p>\n<p> <img loading=\"lazy\" decoding=\"async\" alt=\"\" border=\"0\" src=\"http:\/\/stats.wordpress.com\/b.gif?host=gigaom.com&#038;blog=14960843&#038;%23038;post=611255&#038;%23038;subd=gigaom2&#038;%23038;ref=&#038;%23038;feed=1\" width=\"1\" height=\"1\" \/><\/p>\n<p><a href=\"http:\/\/pubads.g.doubleclick.net\/gampad\/jump?iu=\/1008864\/GigaOM_RSS_300x250&#038;sz=300x250&#038;%23038;c=892247\"><img decoding=\"async\" src=\"http:\/\/pubads.g.doubleclick.net\/gampad\/ad?iu=\/1008864\/GigaOM_RSS_300x250&#038;sz=300x250&#038;%23038;c=892247\" \/><\/a><\/p>\n<p><strong>Related research and analysis from GigaOM Pro:<\/strong><br \/>Subscriber content. <a href=\"http:\/\/pro.gigaom.com\/?utm_source=tech&#038;utm_medium=editorial&#038;utm_campaign=auto3&#038;utm_term=611255+as-genom-sequencing-becomes-more-affordable-should-you-do-it&#038;utm_content=kimaeheussner\">Sign up for a free trial<\/a>.<\/p>\n<ul>\n<li><a href=\"http:\/\/pro.gigaom.com\/2013\/01\/ces-2013-flash-analysis-disruptions-and-disappointments-from-consumer-techs-biggest-show\/?utm_source=tech&#038;utm_medium=editorial&#038;utm_campaign=auto3&#038;utm_term=611255+as-genom-sequencing-becomes-more-affordable-should-you-do-it&#038;utm_content=kimaeheussner\">GigaOM Research highs and lows from CES 2013<\/a><\/li>\n<li><a href=\"http:\/\/pro.gigaom.com\/2012\/07\/the-wearable-computing-market-a-global-analysis\/?utm_source=tech&#038;utm_medium=editorial&#038;utm_campaign=auto3&#038;utm_term=611255+as-genom-sequencing-becomes-more-affordable-should-you-do-it&#038;utm_content=kimaeheussner\">Analyzing the wearable computing market<\/a><\/li>\n<li><a href=\"http:\/\/pro.gigaom.com\/2013\/01\/how-hr-can-make-the-case-for-workforce-analytics\/?utm_source=tech&#038;utm_medium=editorial&#038;utm_campaign=auto3&#038;utm_term=611255+as-genom-sequencing-becomes-more-affordable-should-you-do-it&#038;utm_content=kimaeheussner\">How HR can make the case for workforce analytics<\/a><\/li>\n<\/ul>\n<p><img width='1' height='1' src='http:\/\/gigaom.feedsportal.com\/c\/34996\/f\/646446\/s\/289d3795\/mf.gif' border='0'\/><\/p>\n<div class='mf-viral'>\n<table border='0'>\n<tr>\n<td valign='middle'><a href=\"http:\/\/share.feedsportal.com\/viral\/sendEmail.cfm?lang=en&#038;title=As+genome+sequencing+becomes+more+affordable+should+you+do+it%3F&#038;link=http%3A%2F%2Fgigaom.com%2F2013%2F02%2F15%2Fas-genom-sequencing-becomes-more-affordable-should-you-do-it%2F\" ><img decoding=\"async\" src=\"http:\/\/res3.feedsportal.com\/images\/emailthis2.gif\" border=\"0\" \/><\/a><\/td>\n<td valign='middle'><a href=\"http:\/\/res.feedsportal.com\/viral\/bookmark.cfm?title=As+genome+sequencing+becomes+more+affordable+should+you+do+it%3F&#038;link=http%3A%2F%2Fgigaom.com%2F2013%2F02%2F15%2Fas-genom-sequencing-becomes-more-affordable-should-you-do-it%2F\" ><img decoding=\"async\" src=\"http:\/\/res3.feedsportal.com\/images\/bookmark.gif\" border=\"0\" \/><\/a><\/td>\n<\/tr>\n<\/table>\n<\/div>\n<p><a href=\"http:\/\/da.feedsportal.com\/r\/158400913088\/u\/49\/f\/646446\/c\/34996\/s\/289d3795\/a2.htm\"><img decoding=\"async\" src=\"http:\/\/da.feedsportal.com\/r\/158400913088\/u\/49\/f\/646446\/c\/34996\/s\/289d3795\/a2.img\" border=\"0\"\/><\/a><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"http:\/\/pi.feedsportal.com\/r\/158400913088\/u\/49\/f\/646446\/c\/34996\/s\/289d3795\/a2t.img\" border=\"0\"\/><\/p>\n<div class=\"feedflare\">\n<a href=\"http:\/\/feeds.feedburner.com\/~ff\/OmMalik?a=iVZ3Vgvjjfs:7lHl46NmAZw:yIl2AUoC8zA\"><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~ff\/OmMalik?d=yIl2AUoC8zA\" border=\"0\"><\/img><\/a>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/OmMalik\/~4\/iVZ3Vgvjjfs\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genome sequencing is becoming more affordable than ever before \u2013 several companies in the industry say the $1,000 personal genome is just around the corner. But, even if you can afford it, is mapping your genes worth it if you don\u2019t have a specific medical condition to consider? Despite the whole &#8220;knowledge is power&#8221; argument [&hellip;]<\/p>\n","protected":false},"author":7417,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-642739","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/642739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/users\/7417"}],"replies":[{"embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/comments?post=642739"}],"version-history":[{"count":0,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/posts\/642739\/revisions"}],"wp:attachment":[{"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/media?parent=642739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/categories?post=642739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereja.media\/index\/wp-json\/wp\/v2\/tags?post=642739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}