The gloveman – who dropped four catches as Australia pulled off a miraculous victory at the SCG last week – was forced to ‘drop himself’ as he is part of Paksitan’s four-man selection panel.
Pakistan manager Adbul Raquib said the panel unanimously decided to play Safraz ahead of Akmal.
In other changes, Shoaib Malik and Khurran Manzoor have come in for struggling batsmen Faisal Iqbal and Misbah-ul-Haq, while teenage paceman Mohammad Aamer returns in place of Mohammad Sami.
Meanwhile Australia has recalled opening batsman Simon Katich, who will replace Phillip Hughes at the top of the order.
Pakistan: Mohammad Yousuf (captain), Imran Harhat, Salman Butt, Khurram Manzoor, Umar Akmal, Shoaib Malik, Sarfraz Ahmed, Mohammad Aamer, Umar Gul, Mohammed Asif, Danish Kaneria, Faisal Iqbal (12th man).
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