Author: Serkadis

  • Epson MovieMate multimedia projector hands-on

    Aiming to be a one-stop shop for slumber parties and business meetings alike, the MovieMate projector from Epson combines a projector and a DVD player into one easy-to-tote package. It packs HDMI, PC, and Component / RGB inputs, in addition to built-in speakers. There’s a handle for easy carrying, and we’re glad to report that it’s not too heavy. Thankfully, Epson included a mic input for all those crazy karaoke sessions that might happen in the spur of the moment. Unfortunately there were no karaoke tunes on hand for us to test it out to, so we’ll just have to take their word that it works like a charm.

    Epson MovieMate multimedia projector hands-on originally appeared on Engadget on Thu, 07 Jan 2010 07:45:00 EST. Please see our terms for use of feeds.

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  • Cobra XRS 9970G radar detector has a touchscreen, will not make radar detectors useful

    If you’re thinking switching between city and highway mode on a regular radar detector was pretty easy, well, you’re wrong. What you need is a 1.5-inch touchscreen, as found on the new Cobra XRS 9970G and 9965, which replaces that baffling array of knobs and switches with a baffling array of icons. Of course, none of this will actually make radar detectors effective or relevant, but that’s not really the point here, is it?

    Cobra XRS 9970G radar detector has a touchscreen, will not make radar detectors useful originally appeared on Engadget on Thu, 07 Jan 2010 07:32:00 EST. Please see our terms for use of feeds.

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  • NorhTech Gecko netbook reviewed, small, slow (video)

    The kids at Liliputing finally got a chance to put the 8.9-inch, AA-powered NorhTec Gecko Edubook through its paces and, you know what? It’s slow. Like, every bit as slow as you expected a 1GHz, 512MB of RAM, 8GB SD card storage device to be. The review unit sports the lightweight WattOS (Ubuntu based) Linux distro, although this guy will also support Windows XP if that’s what floats your boat. Sure, it’s cheap (under $200), so if portability is a premium for you, and you don’t really need things like video or Google Docs (which is particularly painful to watch on the included video) you might want to give this one a second look. See for yourself after the break.

    Continue reading NorhTech Gecko netbook reviewed, small, slow (video)

    NorhTech Gecko netbook reviewed, small, slow (video) originally appeared on Engadget on Thu, 07 Jan 2010 07:03:00 EST. Please see our terms for use of feeds.

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  • The James Chicago Hotel Announces Limited-Time “Insider” Rate and Upgrade Offer

    The James Chicago hotel thanks guests with exclusive, limited time rate and upgrade offer

    The James Hotel, located just steps from the famed Magnificent Mile, is making it even easier to take advantage of all the city has to offer with an exclusive limited-time “Insider Sale.”

    For a very limited time, The James will offer an exceptional rate for stays in one of the hotel’s residentially styled guestrooms at just $129 per night including a complimentary upgrade.

    To Jan. 17, 2010, hotel reservations booked through March 31, 2010 may take advantage of the unbeatable offer.

    Guests will also receive a $50 parking inclusion or food & beverage credit to be used in the modern-American steakhouse David Burke’s Primehouse, the sleek Jbar lounge or to enjoy via in-room dining.

    Chicago may be incomparable in the summertime, but true city insiders know there are many reasons to visit the Windy City before the beaches are buzzing.

    Whether attending one of Chicago’s world-renowned St. Patrick’s Day celebrations or spending Valentine’s Day in a cozy urban retreat, visitors to the city can find myriad activities and attractions throughout the year.

    Secure a perfectly appointed room at this downtown Chicago hotel while they’re still available.

    To book, visit the hotel packages page, jameshotels.com/specials or call 312-337-1000.

    About The James Chicago

    The James Chicago, a member of The Leading Hotels of the World, debuted in April 2006 as a stylish alternative for the discerning business and leisure traveler.

    The James defines luxury liberated from tradition; a philosophy evident in the property’s residential environment and personal, intuitive service. Recognized on Travel + Leisure’s “2008 World’s Best Awards,” The James celebrates a lifestyle that is at once beautiful and comfortable, sophisticated and accessible, luxurious and natural.

    The James Chicago is centrally located on the corner of Rush and Ontario, steps from Chicago’s famous Michigan Avenue, Millennium Park and various museums.

    For details, please visit jameshotels.com.

    MEDIA CONTACT:

    Victoria Martinez, 212-981-5217
    Dan Klores Communications
    [email protected]


  • Mc Propeller Flow Meter

    Mc Propeller Flow Meter With Pulse Transmitter For SCADA System Data Logging and Telemetry

    Agriculture and turf irrigation engineers will find the EA631 Pulse Transmitter for the Mc® Propeller Flow Meter from McCrometer provides an interface to Programmable Logic Controllers (PLC’s) in support of Supervisory Data Acquisition (SCADA) Systems useful in irrigation control systems.

    The EA631 is a three-wire pulse transmitter, which is is available with all models of the Mc Propeller Meter or can be easily retrofitted into an existing Mc Propeller meter. Installation of the EA631 does not require removal of an existing flow meter and can be done under flowing conditions. This wafer-style transmitter produces a pulse output that can be used for data logging or telemetry.

    The Mc Propeller Meter is available in various mounting configurations such as bolt-on saddle, flanged, grooved, plain and threaded-end. The meter’s flow range is 40 to 30,000 gallons per minute depending on line size, under pressures up to 150 psi and a continuous operation temperature up to 160°F maximum. It features liquid flow measurement accuracy of +2% of rate and repeatability is +0.25%.

    With its high accuracy, the Mc Propeller Meter is a water management tool that helps reduce water costs, prevents over-irrigating and reduces leaching of chemicals and fertilizers into the ground. The Mc Propeller is especially well suited for dirty irrigation water flows, and other high-volume water applications.

    Unlike traditional propeller meters, the Mc Propeller uses a flexible drive-train and sealed ball bearings. Its unique design makes it easy to service in the field and requires no external power or batteries. The Mc Propeller is designed to comply with AWWA C704-08. Standard features include an instantaneous flow rate indicator and six-digit totalizer.

    The Mc Propeller consists of a rotating device, a helical-shaped impeller, positioned in the flow stream. When fluid passes through the meter, it contacts the impeller causing it to spin. The impeller’s rotational velocity is directly proportional to the velocity of the flow. The rotation is translated through a magnetic coupling and flexible drive system to the register, which calculates the flow rate by multiplying the flow velocity with the cross-sectional area of the meter tube.

  • Wholesale measuring projector CPJ-3015 with USD2900/set

    The movable length of the workpiece and the rotation angle on the projection screen can be digitally displayed
    With a non-spherical collector lighting system, the visual field of the projector screen would be all the more bright and homogeneous thus reducing measurement errors and further securing the accuracy
    With axial flow blower fans, the bilateral heat radiation can provide super-strong radiating power
    Imported long-life halogen tungsten lamps are adopted to satisfy the requirement of long-time uses of the projector
    CPJ-3015 equip 0.5um linear scale and one data processor DC3000

    This instrument is a precession measuring device integrating optics, mechanics, electricity and computation into an organic whole; which is widely used in the measuring rooms and workshops of related factories and plants in the sectors of machinery manufacture, instrumentation, clocks and watches and electronics industries. This instrument can easily and speedily check the profiles and surface shapes of various measured parts; e.g., various parts, cutting tools and tools of sample plates, punching pieces, cams, gears, molding milling cutters, tapping tools, etc.

    Accuracy of the instrument:
    (4+L/25)ìm, of which, L = length of the workpiece measured ( unit: mm)
    Load capacity of the worktable: 5kg
    Lighting source
    Transmission lighting: 12V/100W Halogen tungsten lamp
    Indirect lighting: 24V/150W Halogen tungsten lamp

    Errors of magnifying power: 0.08%

    Remarks on the Power Source:
    Rated voltage for the instrument is 220V/110V
    Frequency: 50HZ/60HZ
    Rated power: 440W

  • Capacitec – Thin gap sensors

    Engineers have long been searching for reliable and repeatable methods to measure thin gaps between 0.004″ (0.11mm) and 0.20″ (5mm). Mechanical contact methods such as feeler gauges, shims and calipers had long been the only available method to measure gaps, even in areas where damage could be caused to polished or sensitive surfaces. Capacitec has eliminated the requirement for the operator’s “feel” inherent in feeler gauges by developing a broad line of non contact industrial gap sensors as well as a new portable gap measurement tool named GAPMAN®. These modern Capacitec non contact methods now provide engineers with excellent repeatability with the added ease of digitally stored data for use in today’s advanced quality control systems.

    Thin Gap Major Applications:
    • Adhesive coatings
    • Film manufacturing
    • Plastic extrusions
    • Automotive & Aircraft assembly
    • Packaging materials
    • Nuclear fuel rod gaps
    • Photocopiers / Printing
    • Tooling dimensions

  • COMPLEX M42

    Cutting edge (teeth) hardened to 69 Rockwell, made from HSS steel containing 8% cobalt.

    High-elasticity back (body) in spring steel alloy containing 4% chromium.

    Hook-shaped teeth with positive rake at 10° and alternating formation: roughening tooth ‘a’, finishing tooth ‘b’ set to the right, finishing tooth ‘c’ set to the left.

    APPLICATIONS
    Ideal for use on large-size metal saws, fitted with automatic descent of the saw-frame. Specifically designed for cutting on solid sections, special steels or particularly hard materials such as Inconel, Hastelloy, Nimonic, Titanium, austenitic steels, refractory alloys, etc..

    ADVANTAGES
    Increased accuracy in the cutting direction.
    Better grade of finish on the cutting surface.
    Increased chip formation ability per minute.
    Reduced cutting pressure.
    Reduced blade wear.

  • Renesas Releases First Product in Multimedia Solution Line of Linux Platforms

    London / Munich, 8th December 2009 — Renesas Technology Europe today announced the availability of the Renesas Multimedia Solution Linux*1 platform, which enables low-cost and rapid development of systems incorporating the SH772x Series application processor for low power multimedia applications such as audio and video for portable and industrial devices. The first product in the series is the MS7724 platform for the SH7724, the newest entry in the SH772x Series. Shipments will begin in December 2009.
    The MS7724 provides improved functionality and performance over current evaluation and development boards incorporating the SH772x Series, while achieving a more compact area approximately 50 % that of previous Renesas products, and a dramatic cost reduction of 65%. This helps lower overall system development costs, for example by enabling customers to purchase multiple boards to shorten development cycles. In addition, the new platform includes software for developing systems running the Linux OS, which is widely used in the application fields of the SH7724, including navigation systems with support for terrestrial digital broadcasts, portable media players, audio and video equipment, such as door entry systems and IP security cameras, and digital signage. This allows evaluation of the device immediately after purchase, contributing to shorter system development cycles and more timely release of products to the market.
    The MS7724 includes, at no additional cost, a comprehensive Linux Board Support Package (BSP) featuring an up-to-date Linux kernel, compiler and tool-chain versions, as well as all the drivers needed for a quick start. Furthermore, sample middleware for audio and video processing and several sample applications such as video recording and video playback enable customers to develop high end audio video systems incorporating the SH7724 multimedia processor running the Linux OS. This means that customers who purchase the MS7724 can immediately commence SH7724 device evaluation and system development work, thereby further reducing system development time.
    The sample application is a complete software program supporting implementation of an IP security camera. It encodes video captured by a camera in H.264 format using the SH7724 hardware, then transfers the resulting signal from the Ethernet interface of the SH7724 to a LAN network or display device via an HTTP server.

  • HIGH PRESSURE ELECTROFUSION MACHINES: ELEKTRA LIGHT

    Elektra Light is a multipurpose low voltage (8÷48V) electrofusion machine capable of fusing any brand of couplers available in the market for the transport of gas, water and other fluids under pressure (HDPE, PP, PP-R). Elektra Light is light and easy to carry, and meets the international welding standards.

    Elektra Light has a memory capacity of up to 350 welding cycles, which can subsequently be downloaded (via adapter DB9M-USB – on request) to a USB flash drive or a serial printer.
    Available with or without optical pen for bar code reading (to set the welding parameters).

    – Universal electrofusion machines
    – For high pressure conduits from Ø 20 to 125/160 mm (for more detail contact RITMO S.p.A.)
    – Optic pen bar code
    – Memory that register 350 welding cycles
    – Data download

    SUPPLIED WITH:
    – Connectors adapters Ø 4,0 mm, Ø 4.7 mm, carrying case, manual scraper

    ON REQUEST:
    – Printer transfer kit (including serial printer and cables)
    – USB transfer cable

    Technical features
    – Working range – 20 to 125/160 mm (for more detail contact RITMO S.p.A.)
    – Welding output voltage – 8 ÷ 48 V
    – Max absorbed power 2000 W / 230 V 50/60 Hz
    – Protection degree – IP 54
    – Dimensions – 200 x 250 x 210 mm
    – Weight 8 Kg

    Ritmo S.p.A.
    Via A. Volta, 7 35037 Bresseo di Teolo (PD) ITALY
    Tel. + 39 049 9901888 Fax: +39 049 9901993 www.ritmo.it – [email protected]

  • Manually operated & semi-automatic circular saws BEWO 250

    Bewo circular saws for metal can be supplied to the following specifications:

    2 speeds double-action stock vice mitre sawing facility
    safety guard pedestal with submerged pump – manual operation
    manual operation with a pneumatic vice

    The thousands of machines that have come off the production line since then have been put to use in almost every kind of industrial process.

    Long service life and low maintenance requirements are key features of these machines; reason enough for many customers to choose Bewo.

    All the machines in the BEWO range are now supplied with a heavy-duty pedestal with a built-in submerged pump.

  • Lee Tergensen Headed For “Law & Order: SVU”

    An Oz reunion is headed for SVU. Lee Tergesen, who starred as Christopher Meloni’s locked-down lover on the defunct HBO defunct prison drama Oz, will appear opposite his former co-star on an upcoming episode of Law & Order: Special Victims Unit. Tergeson will play a religious zealot accused of murder on the NBC crime series, Entertainment Weekly revealed on Wednesday. Fans can expect “lots of sweaty interrogation scenes between Meloni and Tergesen,” says an insider.

    An airdate has not been announced.


  • We Just Finished One Lost Decade, And Here Comes Another One

    zombie

    The stock market’s performance over the next decade will be very similar to the one since 2000: the WSJ appropriately named it “the lost decade.”  Stocks will go up and down (setting all-time highs and multiyear lows), stagnate, and trade in a tight range.  At the end of this wild ride, when the excitement subsides and the dust settles, index investors and buy-and-hold stock collectors will find themselves not far from where they started in 2000.

     Welcome to secular (long-lasting) range-bound markets or, in the tradition of giving pet names to market cycles, what I call the Cowardly Lion market, whose occasional bursts of bravery lead to stock appreciation, but are ultimately overrun by fear that leads to a subsequent descent.

    Over the last 200 years, every long-lasting bull market (and we just had a supersized one from 1982 to 2000) was followed by a range-bound market that lasted about 15 years or so (the only exception was the Great Depression).   Despite common perception, secular markets spent a lot more time in bull or range-bound phases, roughly half in each, and only visited a bear cage on very rare occasions.  This distinction between bear and range-bound markets is seldom made but extremely important, as you’d invest very differently in one versus the other.

    Let me explain why this takes place.  Though it is hard to observe in the everyday noise, in the long run stock prices are driven by two factors: earnings growth (or decline) and/or price-to-earnings expansion (or contraction).  Take a careful look at the two tables and you’ll be hard pressed to find an economic metric that was responsible for a stock market cycle. Though economic fluctuations were responsible for short-term (cyclical) market volatility, as long as longer-term economic performance was not far from the average, secular market cycles were either bull or range-bound.  Valuation – the change in price to earnings, its expansion or contraction – was mainly responsible for markets being in a bull or range-bound phase.

    Prolonged bull markets started with below- and ended with above-average P/Es.  This vibrant combination of P/E expansion (a staple of bull markets, a great source of returns) and earnings growth, which doesn’t have to be spectacular, just more or less average, brings terrific returns to jubilant investors.

    Range-bound markets follow bull markets. As clean-up guys, they rid us of the high P/Es caused by bull markets, taking (reverting) them down towards and actually below the mean.  P/E compression (a staple of range-bound markets) and earnings growth work against each other, resulting in zero (or nearly) price appreciation plus dividends, though this is achieved with plenty of cyclical volatility along the way.

     

    The 1982-2000 the bull market ended at the highest P/Es ever! Thus it will take longer for earnings growth to deflate them.  Though continued economic growth appears to be a wildly optimistic assumption, given what is taking place in the economy, it is not particularly unrealistic to assume that we will see nominal economic growth over the next decade.  The Fed and our government are working very hard to achieve that, at any cost.

    Bear markets are range-bound markets’ cousins; they share half of their DNA: high starting valuations. However, where in range-bound markets economic growth helps to soften the blow caused by P/E compression, during secular bear markets the economy is not there to help. Economic blues (earnings decline) throw water on an already dying fire (the compression of high starting P/Es) and bring devastating results to investors.

    A true, long-lasting bear market has not really taken place in the US, but occurred across the pond in Japan, where stocks declined gradually, and not so gradually at times, falling over 80% from the late 1980s until today.  If the US economy fails to stage a comeback with at least some nominal earnings growth over the next decade, what started as a range-bound market in 2000 will turn into a bear market, as high valuations are already in place.

    Let’s try to figure out the earnings power of the S&P 500.  The current 2010 estimates of its operating earnings are $75, respectively.  I am skeptical of these numbers for several reasons:

    First, they are double those of reported 2010 earnings estimates of $45. The percentage difference between reported and operating numbers is the second highest since 1988.  (2008 holds the record.  During the 2001-2003 recession the difference was about 50%.  “One time” write-offs are responsible for the difference.  It is very likely that these “one-time” charges are not really “one-time;” thus operating estimates overstate the true earnings power of the market.

     

    Second, 2010 estimates are only slightly below the all-time high earnings the S&P achieved in 2007, when our economy was under the influence of several bubbles, which at the time severely inflated corporate profit margins, to unprecedented levels (I’ve written about this in Barron’s).  Also, the bulk of excesses in margins came from the financial, materials, energy, and industrial sectors – the ones that are struggling today and will continue to do so for a long time. 

     

    Finally, if earnings were to be as projected, we’d be following the last recession’s recovery path, which is unlikely.  The last recession was corporate, while the current one is riddled with debt-laden consumers.  Deleveraging the excesses of the housing bubble, in the face of higher future taxation and likely higher interest rates (both byproducts of large deficits) will be a lengthy process.  The recovery will be slower and real earnings growth will be lower than in previous recessions.

     

    It is hard to know the exact earnings power of the S&P 500, but it likely lies somewhere in between operating and reported earnings estimates, and thus closer to $60, putting the P/E of the S&P 500 at about 19.  

     

    Since 1900, stocks have spent very little time at what is known as a “fairly valued” P/E of 15, spending less than 27% of the time between P/Es of 13 and 17 (2 points above and below their “average” level).  They only saw a P/E of 15 when they went from one extreme to another.  Most importantly, they’ve never stopped at the average and gone the other direction: they’ve continued their journey to the other extreme.

     

    During secular bull markets, investor optimism, bundled with constant reinforcement from rising prices, takes stocks to above-average valuations, causing P/Es to expand beyond their long-term average.

     

    P/Es can shoot for the stars, but they don’t get there: at the late stages of the secular bull market P/Es stop expanding. As earnings growth becomes the sole source of returns, disappointed investors start diversifying away from stocks into other asset classes (real estate, bonds, commodities, gold, etc.) – and a range-bound market ensues.  As the range-bound market marches on, unmet expectations reinforce disappointment in stocks, and P/Es are compressed to the other extreme. 

     

    Keeping this in mind, note that stocks are still not cheap, and thus range-bound markets still lie ahead of us.

     

    I should mention the role interest rates and inflation play in market cycles.  They are secondary to psychological drivers, but important.  They don’t cause the cycles but help to shape their duration and the valuation extremes stocks achieve.  For instance, if at the end of the 1966-1982 range-bound market interest rates and inflation had not been in the mid-teens,  the range-bound market would have ended sooner, at higher P/Es.  On the other hand, if in the late 1990s interest rates and inflation had not been scraping low single digits, the bull market would have ended sooner and at lower P/Es.  The higher inflation and interest rates that are around the corner will take their toll on the duration and final P/E of this market as well.

     

    In range-bound markets, as P/Es compress they turn against investors; thus investment strategy in this very different and difficult environment needs to be adjusted for the new investment reality:

    –          Become an active value investor.  Traditional buy-and-forget-to-sell (hold) strategy is not dead but is in a coma waiting for the next secular bull market to return; and it’s still far, far away.  Sell is not just another four-letter word; sell discipline needs to be kicked into higher gear.

    –          Margin of safety needs to be increased.  Typically, value investors seek for margin of safety to protect them from overestimating the “E”.  In this environment it needs to be beefed up to accommodate the impact of constantly declining P/Es.

    –          Don’t fall into the relative valuation trap.  Many stocks will appear cheap based on past valuations, but past secular bull market valuations will not be in vogue for a long time, thus absolute valuation tools such as discounted cash-flow analysis should carry more weight.

    –          Though timing the market is alluring, don’t – it is very difficult to do it consistently.  Value individual stocks instead. Buy them when they are undervalued and sell them when they become fairly valued.

    –          Increased margin of safety and stricter sell discipline will lead one to have a higher cash position at times.  Don’t invest for the sake of being invested, because this will force you to own stocks of marginal quality or ones that don’t meet your heightened required margin of safety.  Secular bull markets taught investors not to hold cash, as the opportunity cost of doing so was very high.  However, the opportunity cost of cash is a lot lower during a range-bound market.

    And what if a range-bound market isn’t in the cards? If a bull market develops, active value investing should do at least as well as buy-and-hold investing or passive indexing. In the case of a bear market, your portfolio should decline a lot less.

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  • Vergessene Episoden der deutschen Geschichte

    Heute:
    Politiker üben Druck auf Jürgen Klinsmann aus!

    Nach der Niederlage gegen Italien vor der WM meldete sich die FDP Sportbeauftrage Miriam Gruß zu Wort und forderte:

    Quote:

    Bei der WM gehe es um ein nationales Anliegen!!…..
    Die Zeit ist knapp. In weniger als 100 Tage vor der WM sollte Klinsmann nicht mehr experimentieren!!
    Klinsman soll endlich dem Sportausschuss des Bundes sein Konzept erklären. Es geht ja nicht nur darum, ob eine Mannschaft mal schlecht spielt, sondern um die Frage: Wie präsentiert sich Deutschland!!!


  • Is this really a motorized skateboard?

    7232008SSB3

    My buddy Paul just bought this odd $229 motorized skateboard – you know, for kids. It apparently runs at 12 miles an hour and can support an adult up to 250 pounds. I’ve never seen these – it seems like they’re the logical follow-up to the pocket bike craze.

    # This smooth-riding board can scramble to 12 miles per hour thanks to its 150 watt electric engine.
    # Travels approximately 12 miles (flat ground) on a single charge.
    # Two speeds – low gear uses 12 volts and then shifts to high gear and 24 volts. This is done automatically as the speed builds up.
    # Can support up to a 250 pound adult

    Have you guys seen these? Will we kill ourselves riding them? You can get them on eBay, which makes me think they might not be amazingly hight quality.


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  • BHP Headquarters

    Is there anyone out there in Skybar World know if BHP Billiton will move to the new CitySquare building in Perth once it is complete in a couple of years? It probably makes sense to move closer to where the real action is occuring (at least in their field). Will be interesting to see what happens.
  • Adam Lambert “Glee” Guest Star

    American Idol alum Adam Lambert just signed on for a special guest appearance on FOX’s musical breakout hit Glee, if a report featured in this week’s issue of The National Enquirer is to be believed. Word is the openly-gay glam rock star will be playing a mentor to closeted character Kurt on an episode airing this April.


  • Biogen Idec CEO Stepping Down, Ambrx Focuses on Empowered Antibodies, Intellikine Testing First Drug Candidate, & More San Diego Life Sciences News

    Bruce V. Bigelow wrote:

    San Diego’s biotech community got busy in the first week of 2010, with a flurry of news falling as heavily as a New England snowstorm. Better get your snow shovel.

    James Mullen announced his plans to retire June 8 (at the tender age of 51) as CEO of Cambridge, MA-based Biogen Idec (NASDAQ: BIIB). Mullen was promoted to head Biogen in 2000 and assumed command of the combined companies following the 2003 merger of Biogen with San Diego-based Idec Pharmaceuticals. In recent years, however, Mullen became a lightning rod for criticism among activist shareholders (including billionaire Carl Icahn), who complained that Biogen Idec shares were underperforming in comparison with biotech peers.

    —San Diego-based Ambrx CEO Steve Kaldor told Luke that about one-third of the biotech firm’s staff—and half of its resources—are now focused on building on recent breakthroughs in the development of antibody drug conjugates, a class of protein drugs also known as “empowered antibodies.” For example, Ambrx is developing a new anti-cancer drug, called T-DM1, that combines the ability of an antibody to seek out cancerous cells with a potent toxin that gives the treatment extra tumor-killing kick.

    —San Diego’s Intellikine is still on a fast track to develop drug candidates that block a hot cancer target known as the PI3 kinase. Kinases are a type of enzyme that control complex cellular processes, usually by transferring phosphate molecules to specific places in the cells. Intellikine is developing a portfolio of drug candidates designed to disrupt the processes controlled by the PI3 kinase. Intellikine, which was founded a little more than two years ago, is now testing its first drug candidate in humans.

    —San Diego-based Sequenom (NASDAQ: SQNM) settled a dispute with Michigan-based SensiGen by issuing about $1.5 million worth of Sequenom shares. After the value of Sequenom shares plunged last year, a lawyer for SensiGen asserted claims that Sequenom had breached representations made when Sequenom acquired SensiGen’s molecular diagnostic tests.

    —San Diego’s Adventrx Pharmaceuticals (AMEX: ANX) said it has submitted a new drug application for a new formulation of the anti-cancer drug vinorelbine that Adventrx says has fewer side effects. The application represents an extraordinary comeback for the biotech, which announced plans last March to substantially end its operations. Adventrx also said it was raising $19 million through a private placement of its convertible preferred shares.

    —With technology developed at the Los Alamos National Laboratory, Carlsbad, CA-based Life Technologies (NASDAQ: LIFE) has developed a new type of flow cytometer, used to count and catalog large numbers of cells in a biological sample. The new design uses sound waves to measure the size and type of certain cells flowing through a tube.







  • Millions of app store downloads everywhere

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    Last year was a big one for mobile downloads, according to a number of sources. A Quantcast mobile trends report says that mobile web activity grew 110% in the US throughout 2009, and of course Apple was responsible for most of that, with a 65% market share, 41% from the iPhone and the rest from the iPod touch. Apple’s market share slightly dropped in 2009 (due to increasing competition), but it’s still head and shoulders above everyone else.

    App downloads are huge as well. Not only did Apple announce that three billion downloads, but Gameloft says they’ve reached 10 million paid downloads of apps by themselves, and developer Lima Sky (makers of Doodle Jump, one of our favorite games of 2009), says downloads skyrocketed after Christmas, with over 500,000 downloads of their app in December of 2009 alone.

    The App Store is doing big business lately — it’s probably a safe bet to say that 2009 kicked off a golden age of mobile web activity. And all indications are that 2010 will be even more interesting.

    TUAWMillions of app store downloads everywhere originally appeared on The Unofficial Apple Weblog (TUAW) on Thu, 07 Jan 2010 07:00:00 EST. Please see our terms for use of feeds.

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  • Mini Sony Xperia X10 Spotted

    The Xperia X10 was just announced for Canadian wireless carrier Rogers, but already we are being introduced to its smaller sibling, codenamed “Robyn”. Described as “compact and clever”, it looks similar to the X10 although little is known about physical specs. Like the X10, Robyn will also have the Timescape interface (you can catch a video of Timescape in action here).

    Features which can be verified from the pictures are that it sports a camera and will be available in multiple colors. Se-blog claims the camera will be 5-megapixels with autofocus, and that the Robyn will also feature a 3.5 mm audio jack, USB connector, and will support HSPA and WLAN.