Author: Bruce V. Bigelow

  • Sony Electronics Outlines its 3D Strategy, Fallbrook Files For IPO, Electronics Recycler EcoATM Raises Venture Round, & More San Diego BizTech News

    Bruce V. Bigelow wrote:

    It was a great week for innovation in San Diego, with Fallbrook Technologies filing for an IPO and Sony Electronics previewing its 3D strategy (along with some new products) after opening the doors of its new $160-million North American headquarters.

    Sony Electronics showed off its new 11-story North American headquarters building in San Diego during an open house that included a press briefing and demonstrations of the new Sony Dash, a personal Internet appliance, and other consumer electronics products. Sony also plans to make a big marketing push for 3D television and related technologies later this year.

    —San Diego’s Fallbrook Technologies intends to raise $50 million through an initial public offering, according to a regulatory filing. Fallbrook is a cleantech venture developing a proprietary transmission that offers improved efficiency for a variety of vehicles.

    —Tao Venture Partners of San Diego is leading the first round of institutional investment in ecoATM, a local startup that has developed an automated kiosk for recycling consumer electronics. Coinstar founder Jens Molbak also joined in the round, the value of which was undisclosed, and has joined ecoATM’s board. Co-founder Mark Bowles also told us why he thinks ecoATM is a hot startup deal.

    —San Diego-based Qualcomm (NASDAQ: QCOM) revealed plans to roll out a variety of new applications that enable certain features of its Flo-TV technology to run on netbooks equipped with Qualcomm’s Snapdragon processor. Qualcomm previewed its concept last week in Barcelona at the industry’s Mobile World Congress.

    —San Diego telecom startup TelCentris announced the debut of a universal translator service for e-mail, text messaging, Internet chat, and certain social networking messages. The translation service has been integrated into its VoxOx VoIP messaging software.

    —Cleantech investor Jim McDermott, a co-founder of U.S. Renewables Group, told a San Diego audience that a lot of innovation remains to be done in wind power technologies.







  • Hollis-Eden Now Harbor BioSciences

    Bruce V. Bigelow wrote:

    San Diego drug developer Hollis-Eden Pharmaceuticals says it has changed its name to Harbor BioSciences, nearly a year after the company fired Richard Hollis, the biotech’s namesake founder and CEO, for cause unknown. Harbor BioSciences also changed its ticker symbol to (NASDAQ: HRBR), saying that shares would begin trading under the new ticker today. The biotech says it is continuing to develop a new steroid analog that stimulates apoptosis, or programmed cell death, in hormone-dependent prostate tumors.







  • Renewable Energy Investor Says Wind Industry Ripe for Innovation

    Wind farm
    Bruce V. Bigelow wrote:

    You could say I blew into the wind power event that Cleantech San Diego organized here last week. The canapés were gone by the time I arrived, but the show was just getting started. I got there in time to hear keynote speaker Jim McDermott of energy investment fund U.S. Renewables Group describe a somewhat stormy outlook for renewable energy companies developing wind projects.

    In surveying the windswept landscape, McDermott sees plenty of opportunities for wind energy developers. “There’s a huge amount of class 3 wind out there,” he says, referring to the basic level of wind energy required if providers want to pour power into the electrical grid. “There’s even still some class 4 and 5 out there, particularly in the offshore markets.”

    In the United States, McDermott says about 300 megawatts of wind power were under development in 2008—which dwarfs the amount of biomass, geothermal, solar, and every other type of renewable energy under development. But with the collapse of the capital markets and the massive downturn, McDermott says there’s also been a tremendous amount of carnage.

    About one-third of the projects under development—representing about 100 megawatts of renewable energy—were effectively wiped out. “Not that these were bad projects,” McDermott says. “There was just no money. For about six months, there was no money for any project at any price.” He estimates that major utilities stepped in to acquire another 100 megawatts of project assets—at cost.

    Wind developers have little choice because the number of major financial firms willing to finance such projects has plunged by two-thirds, the amount of capital available has substantially shrunk, and financing terms have become much more stringent. McDermott says USRG sees what’s left as an investment opportunity because project valuations have fallen dramatically.

    Nevertheless, wind power remains the dominant renewable energy technology. McDermott says 75 percent of all renewable energy assets that are built in the United States are wind-powered. In short, the market is ripe for innovation.

    “There is a lot of innovation that remains to be done in terms of the blades, turbines, gear boxes, and everything else,” McDermott says. As an example of …Next Page »







  • San Diego-Based Sony Electronics Ready to Talk About 3D And Other Innovations

    Sony logo
    Bruce V. Bigelow wrote:

    Sony Electronics usually maintains a low corporate profile at its North American headquarters, even though it ranks among San Diego’s biggest private employers—with roughly 2,000 workers here. That seemed especially true after its corporate parent announced a massive reorganization at this time last year, which included hundreds of Sony layoffs in San Diego.

    So it seemed unusual when Sony Electronics recently broke radio silence. The consumer electronics business organized an open house at its new 11-story building here—and invited hundreds of dealers, less than two months after courting them at the annual Consumer Electronics Show in Las Vegas. The unexpected glasnost even extended to some journalists like me, who were invited to join the trade press for a Q&A session with two of Sony Electronics’ top executives. We also got briefing on Sony’s push into 3D technologies.

    The session included a demonstration of the new “Dash—a personal Internet appliance, alarm clock, and online media-streaming device based on technology that Sony licensed from San Diego-based Chumby Industries, the startup behind the soft-and-cuddly Chumby web terminal.

    Stan Glasgow

    Stan Glasgow

    Stan Glasgow, Sony Electronics’ president and chief operating officer, says the Dash is an example of the company’s renewed focus on consumer trends and demographics. Women, in particular, influenced its development, according to Edgar Tu, president of Sony TV Engineering of America. Sony says more than 1,000 free apps are available for the device, which connects to an existing home or office wireless network, so people can use it to access websites for recipes, weather, traffic reports, news, and other information. Tu tells me the Dash even features a 7-inch waterproof LCD touch screen, so people can use it in the bathroom and kitchen. It will be available in April for $199.

    Sony’s new focus on consumer trends has grown so keen, in fact, that Glasgow says Sony and CBS have established a …Next Page »







  • Fallbrook Technologies Files for $50M IPO

    Bruce V. Bigelow wrote:

    San Diego’s Fallbrook Technologies, a cleantech venture developing a proprietary transmission that offers improved efficiency for a variety of vehicles, intends to raise $50 million through an IPO, according to a filing today with the Securities and Exchange Commission.

    A Fallbrook spokesman declined to comment on the stock offering.

    In its filing, Fallbrook says its “NuVinci” design (for a continuously variable “planetary” transmission) can be used in automotive accessory drives (such as air conditioning compressors), and as the primary transmission in electric vehicles, bicycles, riding lawn-mowers, and small wind turbines. While the specific benefits vary with each application, Fallbrook says its technology can lower overall energy costs in each of these areas by improving performance and fuel economy.

    The company previously told me its technology also is well-protected by patents, which is unusual because the big three automakers typically dominate technology innovations in the auto industry. In its filing, Fallbrook says it holds 85 U.S patents, and has another 61 pending. It also holds 71 foreign patents, with 147 pending.

    The company says it has raised about $55 million from investors since it was officially founded in 2000 as Motion Systems Technologies. It was renamed Fallbrook Technologies in 2004. Individual investors funded Fallbrook’s operations for more than a decade, until the company raised $29.4 million last year in its first venture round. The filing shows that entities associated with Robeco, the investment arm of Rabobank of The Netherlands, have a 24 percent stake in Fallbrook. NGEN Partners, a Santa Barbara cleantech venture firm, holds about 23.7 percent, and entities associated with Qualcomm scion Gary Jacobs have a 12 percent stake.

    Fallbrook said it generated almost $2.3 million in revenue in 2008, primarily from …Next Page »







  • Qualcomm Previews Flo-Enabled Content

    Bruce V. Bigelow wrote:

    Qualcomm, the San Diego wireless technologies giant, says it is previewing a variety of new applications at this week’s Mobile World Congress in Barcelona that enable certain features of its Flo-TV technology to run on netbooks equipped with Qualcomm’s Snapdragon processor. Qualcomm says its technology combines live mobile TV programming with real-time Web content and access to popular social networking sites like Twitter. For instance, sports fans watching a live match can use a social networking site to engage other fans while also getting teams stats and other data via real-time data streaming.







  • San Diego Gets $4.95M to Boost Life Sciences Employment

    Bruce V. Bigelow wrote:

    A $4.95 million grant from the federal stimulus package will be used to boost education, training, and placement services for people who are seeking jobs in San Diego’s life sciences and health care professions, according to local biotech and education leaders.

    The grant is part of more than $225 million in stimulus funds awarded by the U.S. Department of Labor to create jobs in health care and related high growth industries. About $100 million is intended to help train health care workers throughout California, according to a statement issued by California Gov. Arnold Schwarzenegger. In addition to providing training and certification, the governor says the funding is intended to help health care providers adopt and expand the use of health information technology.

    In a statement, Schwarzenegger says, “The health IT grants will help California build a world class system to promote and expand the way information is shared, protecting medical privacy, promoting efficiency, and will ultimately help reduce health care costs.”

    The three-year grant allotted for the San Diego region will be used to boost a collaborative education and training program for more than 1,000 incumbent and unemployed workers in the life sciences, according to an announcement issued by San Diego State University, Biocom, the San Diego Workforce Partnership, and the Southern California Biotechnology Center at Miramar College.

    Known as the BRIDGE, (Biotechnology Readiness, Immersion, Certification, and Degrees for Gainful Employment), the collaborative education and training program is focused on the critical need for clinical laboratory scientists, medical laboratory technicians, medical physicists, and scientists. The program also is intended to help military veterans find employment opportunities in the life sciences and health care.







  • Veoh Networks RIP, Connect Is Recruiting an Innovation Lobbyist, Envision Solar Goes Public, & More San Diego BizTech News

    Bruce V. Bigelow wrote:

    The big news last week came from venture-backed Veoh Networks, which is filing for bankruptcy liquidation. Founder Dmitry Shapiro told me Veoh was the biggest Internet company that San Diego has ever seen (see below).

    —San Diego’s Veoh Networks, a video streaming website, was officially launched in 2005. It raised $70 million in venture capital, grew to 23 million unique visitors a month, and was generating about $1 million in advertising revenue every month. But Veoh Networks pulled the plug last week, and founder Dmitry Shapiro told me a copyright infringement lawsuit sounded its death knell (even though it won a summary judgment in the case).

    Connect, the San Diego non-profit that supports local technology and entrepreneurship, has decided to hire a lobbyist and set up an office in Washington DC, at an estimated cost of $400,000.

    Envision Solar, a privately-held solar development firm founded by San Diego architect (and Xconomist) Robert Noble, will soon become a public company following a reverse merger with a dormant public company. Noble told me Envision Solar needs capital to expand its capabilities in developing solar-integrated infrastructure and building systems.

    —Wind turbine technologies startup Viryd Technologies, which was spun out last May by San Diego’s Fallbrook Technologies, just raised $5 million from existing angel investors and China’s Ningbo Shentong Auto Decorations.

    —There will be lots of wireless news coming out this week from Barcelona, where the GSMA Mobile World Congress began yesterday. Novatel Wireless (NASDAQ: NVTL), for example, last week claimed it had made the first data transmission call using Long Term Evolution (LTE) 4G technology.

    —At a time when people spend spend more and more of their lives on the Internet, why does online advertising represent only a fraction of the total amount of advertising? Russ Mann, the CEO of San Diego-based Covario, said the answer could be that the Gen-Xers, who are more comfortable using the Internet, social networking sites, and computers, will have to assume command of corporate marketing departments before we’ll see widespread change.

    —San Diego-based Leap Wireless was the subject of fresh merger rumors earlier this month, after The Wall Street Journal reported that Leap has hired investment bankers to advise the company. Now rumors are also circulating about a Leap rival, Dallas-based MetroPCS, after Reuters reported last week that MetroPCS has hired investment banking firms JPMorgan Chase & Co. and Credit Suisse Group AG. Leap and MetroPCS were in a merger deal that fell apart in 2007 after the two low-cost wireless carriers failed to agree on a price.







  • VoxOx Debuts Translator-in-the-Cloud for Instant Messaging, E-mails, Texting, Social Media

    voxox_logo
    Bruce V. Bigelow wrote:

    Today San Diego-based TelCentris is announcing at the Mobile World Congress in Barcelona that it has incorporated a new free offering—a “universal translator”—as part of VoxOx, its free, cloud-based, unified communications service.

    Some online services, such as Babelfish.com, currently enable users to copy and paste in foreign language text to get a translation. But TelCentris says its VoxOx Universal Translator is the first translation service built into messaging and VoIP messaging software—making VoxOx the first to provide an instantaneous foreign language service that automatically translates e-mail, text messaging, Internet chat, and certain social networking messages.

    VoxOx client

    VoxOx client

    It’s a cool feature, kind of Star Trek-y, and the announcement is tailor-made for the wireless industry’s biggest international conference, which just happens to be held this week in a big international city. TelCentris spokesman Erik Bratt tells me the VoxOx Universal Translator is an ideal application for companies that do a lot of international business. The company’s cloud-based translation software currently supports 50 languages for instant messaging, e-mail, and social media; it also supports 37 of those languages for text messaging.

    In a statement issued by the company, TelCentris president Michael Faught says …Next Page »







  • After Pulling Plug, Veoh Networks’ Dmitry Shapiro Says Litigation “Choked Off Our Oxygen”

    veoh-logo
    Bruce V. Bigelow wrote:

    In the beginning, San Diego’s Veoh Networks had the support of several prominent VCs, and some of the biggest names in the media business. Venture firms like Boston’s Spark Capital, and names like Michael Eisner, the former Disney titan. After five years, founder Dmitry Shapiro tells me the site had 23 million unique visitors a month, and was by far the largest Internet company that San Diego has ever seen.

    But it all came to an end. Veoh Networks pulled the plug this week, even though it kept growing its advertising base and had a run rate of $1 million a month, Shapiro says. All this despite the fact that Shapiro had cut costs—and had been running Veoh with a skeleton crew of less than 20 employees since last April, when he replaced CEO Steve Mitgang as CEO.

    “We had good backers,” says Shapiro, who served as Veoh’s chief innovation officer during the growth years, when the Web-based video streaming company had 120 employees in San Diego and Los Angeles. “We all had big appetites for what we were trying to do, which was create a multi-billion dollar Internet media company.”

    Dmitry Shapiro

    Dmitry Shapiro

    Shapiro, who is one of San Diego’s most-visible techies, started the company in late 2004. Veoh officially launched its business in 2005, and raised close to $70 million in the ensuing years. But the business laid off its remaining 18 employees on Wednesday, and now faces a Chapter 7 liquidation in federal bankruptcy court.

    Shapiro says he’s not even sure whether the paperwork will be filed in San Diego or Los Angeles. “It doesn’t matter,” he says.

    Shaprio says he also doesn’t know what will happen with the millions of videos that have been uploaded to Veoh’s website from users around the world. A trustee who will be appointed by the bankruptcy court to oversee the liquidation will have to decide whether or not to maintain the vidos and keep the website operating.

    In addition to Spark Capital and Eisner’s Tornante Co., the investors that will be writing off their bet on Veoh include …Next Page »







  • Verdezyne Raises $9M

    Bruce V. Bigelow wrote:

    Carlsbad, CA-based Verdezyne, an industrial biotechnology company developing methods for using yeast to make industrial chemicals, has raised $9 million in an ongoing $15.2 million venture round, according to spokeswoman Risa Goldman Burgess. She said today the funding is being used to validate technology, which Verdezyne recently disclosed, for making adipic acid, a key feedstock chemical used to make nylon. Verdezyne’s existing investors include Monitor Ventures, OVP Venture Partners, the Tech Coast Angels, and the Life Sciences Angels.







  • Shutdown Reported at Veoh Networks, Backed by Boston’s Spark Capital and Other VCs

    veoh-logo
    Bruce V. Bigelow wrote:

    The lights are on, but is anybody left at Veoh Networks?

    We’re seeing multiple accounts of sweeping layoffs at Veoh, the San Diego-based Internet TV service, with several citing a report by Media Memo’s Peter Kafka, who says a Chapter 7 bankruptcy liquidation is expected soon.

    I sent a quick e-mail to Veoh CEO Dmitry Shapiro, asking if he could discuss reports of Veoh’s bankruptcy filing. He replied: “Not yet… stay tuned.”

    Veoh’s website is still accessible, but the venture was pronounced dead in a tweet today by Veoh board member Todd Dagres of Spark Capital, a Boston VC firm that invested in Veoh Networks. Dagres tweeted, “Veoh is dead. Universal Music lawsuit was the main killer. Veoh won resoundingly but was mortally wounded by the senseless suit. Next.”

    Dagres was referring to a copyright suit filed that Universal Music Group filed against Veoh, arguing that Veoh didn’t work hard enough to keep Universal’s copyrighted material from being uploaded illegally to Veoh’s website. A federal judge ruled last September that Veoh was protected from Universal’s infringement claims.

    Veoh had raised more than $67 million in venture funding from backers that included Spark, Shelter Capital Partners, Goldman Sachs, Adobe Systems, Intel Capital, and Time Warner Investments.

    As Shapiro says, stay tuned…






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  • Envision Solar Reveals Move to Become Public Company

    Envision Solar logo
    Bruce V. Bigelow wrote:

    San Diego architect (and Xconomist) Bob Noble says that Envision Solar, the solar development firm that he founded in 2005, will soon begin trading shares over the counter after completing a reverse merger with a dormant public company. He announced the move at a reception held last night for about 75 friends and colleagues, which he characterized as a “celebration for what we’ve done after a tremendous amount of work over many months.”

    Noble tells me that Envision Solar needed capital to expand its capabilities in developing solar-integrated infrastructure and building systems. As a public company, he says Envision Solar can get more exposure and benefit from broader investor interest.

    “We have created a platform for growth,” Noble tells me. “I’ve identified key opportunities and business in distributed solar power generation worldwide.”

    Envision Solar ParkingNoble’s vision for what he calls “distributed solar power generation” represents a scenario that many utilities have been unwilling to contemplate, at least until recent years. Utilities have long preferred a centralized power generation scheme that puts an industrial-scale power plant at the hub of electricity distribution. In contrast, distributed generation is more of a “small is beautiful” concept in which electricity is generated on a small scale by power producers scattered throughout a power grid.

    As I’ve reported, Envision Solar got …Next Page »







  • Wind Power Industry Convenes in San Diego Amid Howls Over Which Way Stimulus Funds Are Blowing

    Wind farm
    Bruce V. Bigelow wrote:

    The movers and shakers in wind power are gathering in San Diego this week for what some renewable energy advocates view as the U.S. industry’s most important annual meeting—the Wind Power Finance & Investment Summit. They may be in for a chilly reception, though, with recent news accounts that foreign energy companies have been reaping a windfall in U.S. economic stimulus funding.

    More than three-quarters of the $2 billion in federal stimulus funding that’s been awarded to help create green jobs in the U.S. has gone to foreign-owned companies, according to a front-page story published yesterday by The San Diego Union-Tribune. An analysis of wind-energy grants was initially released in October by the Investigative Reporting Workshop, a nonprofit at American University in Washington D.C.

    The Union-Tribune published a follow-up report, prepared by the nonprofit Watchdog Institute at San Diego State University, that focused on grants that went to foreign wind energy companies with offices in San Diego County. The list includes Eurus Energy America, the La Jolla-based subsidiary of a Japanese company that got $91 million to build a wind farm in western Texas; enXco, the U.S. headquarters of a French-owned company that got $69.5 million to develop a wind farm in Indiana; and the Canon Power Group, with offices near Torrey Pines, which got $19 million to expand its wind farm near Klickitat, WA.

    Several wind industry executives explained in the report that development of their U.S. renewable energy projects would have come to a standstill without the funding provided through the …Next Page »







  • As Advertisers Expand Online, Covario Adds Web-Based Tools to Measure Their Success

    Covario_logo
    Bruce V. Bigelow wrote:

    A new generation of corporate marketing executives was in attendance last week when San Diego-based Covario convened its fourth annual corporate partners conference at the downtown Hard Rock Hotel. As a rock band jammed onstage, the gathering crowd included JP Morgan Chase’s vice president of search governance, Amgen’s senior marketing manager for oncology, and the consumer insight manager for Sony Online Entertainment.

    Search governance? Consumer insight? Welcome to the world of corporate search engine marketing.

    Covario, a startup backed by Seattle-based Voyager Capital, Dubilier & Co., and FT Ventures, specializes in interactive marketing technologies and services. It holds the meeting each year to discuss the latest trends in the highly specific world of search engine marketing and online advertising.

    Search engine marketing, which promotes websites in search engine results by paying to ensure certain search terms are displayed (and by other techniques), is a highly profitable business dominated by Google, Yahoo, and Microsoft. Covario operates in a different segment,  providing Web-based tools, analytical software, and other technologies that enable companies to optimize their websites and to measure just how much bang they get for each search-term buck they pay to Google and the other big boys.

    Search engine marketing is growing much faster than traditional advertising. For all its precision, however, search marketing remains a …Next Page »





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  • Sequenom Gets Rights to Genetic Test for Vision Disorder

    Bruce V. Bigelow wrote:

    San Diego-based Sequenom (NASDAQ: SQNM) says it has obtained rights to develop and commercialize a diagnostic test from New Haven, CT-based Optherion to predict a patient’s genetic predisposition to late-stage, age-related macular degeneration, a progressive eye disorder that can lead to a loss of central vision. Financial terms of the licensing agreement were not disclosed. Once the test is developed, Sequenom says it plans to market the new test next year under its SensiGene brand for genetic tests.







  • Novatel Claims First LTE Data Call

    Novatel logo
    Bruce V. Bigelow wrote:

    In what may be a pre-emptive announcement before next week’s GSMA Mobile World Congress in Barcelona, San Diego’s Novatel Wireless (NASDAQ: NVTL) says it has successfully made a data transmission call using Long Term Evolution (LTE) 4G technology.

    LTE is one of several next-generation wireless technology standards that promise increased capacity as cell phone users increasingly download data, photos, and video from the Internet. Novatel says LTE can provide data rates as high as 50 megabits per second on the uplink and 100 megabits per second on the downlink and “an enhanced user experience by leveraging new, wider bandwidth spectrum.”

    But as Phone Scoop blogger Eric M. Zeman notes, “Novatel didn’t state what speeds it attained, nor whether or not the equipment used was standards compliant.”

    Novatel says that many wireless system operators are planning to overlay fourth-generation LTE systems on their existing 3G networks to augment data capacity in important areas. The company also says it is working with operators, which it did not identify, and plans to launch commercial data services later this year. In the statement issued by Novatel, CTO Slim Souissi says, “We believe our aggressive development efforts will enable us to deliver these innovative solutions with the fastest possible time to market.”







  • Connect Creates Post for Innovation Lobbyist in Washington DC

    Connect Logo
    Bruce V. Bigelow wrote:

    Connect, the San Diego non-profit that supports local technology and entrepreneurship, says it is opening an office in Washington D.C. “to be part of the process,” and to represent the interests of San Diego’s innovation community.

    Establishing a lobbyist in Washington was a key part of an initiative that Connect CEO Duane Roth unveiled last summer that was intended spur San Diego’s innovation economy. Roth’s plan primarily called for increasing federal funding for research and development in San Diego, and for encouraging the formation of more elite research institutions here.

    In a statement e-mailed this evening, Roth says Connect’s new advocate will focus in five areas:  intellectual property (including trade and anti-trust); funding for basic research; regulatory issues; investment capital; and workforce development (i.e. foreign worker visas).

    Connect says Roth has been working with a search committee to recruit a full-time advocate for the office, which will be at the University of California’s 11-story complex in northwest Washington. It was unclear how the position will be funded. In its statement, Connect says only that its board of directors supported “the establishment of a Washington office to provide a consistent presence and close relationships with legislative offices and Administration officials.”







  • Relocated Biotech Raises $2.3M

    Bruce V. Bigelow wrote:

    NexMed (NASDAQ: NEXM), a New Jersey life sciences company that moved to San Diego following its acquisition three months ago of Bio-Quant, a San Diego contract research organization (CRO), says today it has raised $2.3 million in promissory notes from two investors. NexMed says it intends to use the proceeds for general corporate purposes, and to advance its transdermal drug delivery technology, which is intended to enhance the absorption of an active drug through the skin. NexMed says it also is developing topical drugs for treating a fungal infection that affects fingernails and toenails, erectile dysfunction, and female sexual arousal disorder.








  • Tragara Raises $5M

    Bruce V. Bigelow wrote:

    San Diego-based Tragara Pharmaceuticals, which has focused its current drug development on two compounds for treating tumors, has raised $5 million of a targeted $10 million venture round, according to a recent regulatory filing. The company raised $40 million in its Series A round in 2007. Tragara’s filing did not identify the investors in its current round, but the company’s website identifies its existing investors as Domain Associates, Mitsubishi, Morgenthaler Ventures, Oxford Bioscience Partners, and ProQuest Investments.