Category: News

  • UCLA prostate cancer research program receives $11.6 million federal grant

    UCLA’s Jonsson Comprehensive Cancer Center and the department of urology at the David Geffen School of Medicine at UCLA have been notified that their standing as a National Cancer Institute Specialized Program of Research Excellence (SPORE) site in prostate cancer has been renewed for another five years. 
     
    The UCLA program is under the leadership of principal investigator Dr. Robert Reiter, Bing Professor of Urologic Research and a member of the Jonsson Cancer Center. 
     
    This renewal marks the beginning of a third five-year cycle of funding that will support UCLA scientists’ efforts to improve the prevention, detection and treatment of prostate cancer. Thirty-thousand American men are expected to die from the disease this year, and the NCI estimates that more than 238,000 men will be diagnosed with prostate cancer in 2013.
     
    The SPORE program is a central component of NCI’s efforts to spur collaborative, interdisciplinary cancer research at academic centers throughout the U.S., with the goal of translating basic research from the laboratories into patient care more quickly and effectively. The five-year, $11.6 million grant will help UCLA expand its renowned prostate cancer program, which engages researchers and clinicians from many disciplines across campus to uncover the mysteries of the disease.
     
    “The SPORE grant will robustly continue the outstanding programs we have developed over the last two cycles of the grant and give us the resources to bring investigators together for new innovative and multidisciplinary projects with the goal of improving the way we diagnose and treat prostate cancer,” said Dr. Mark Litwin, professor and chair of UCLA’s department of urology.
     
    “This renewal of the UCLA prostate SPORE is indicative of the world-class research we have on this campus,” said Dr. James Economou, UCLA vice chancellor for research and professor of microbiology, immunology and molecular genetics; molecular and medical pharmacology; and surgical oncology.
     
    “The renewal of this SPORE grant is affirmation of the leadership role UCLA continues to play in groundbreaking research on prostate cancer,” said Dr. Eugene Washington, vice chancellor for health sciences and dean of the Geffen School of Medicine.
     
    “Over the past 10 years, the UCLA prostate SPORE has had some great successes,” Reiter said. “Among them have been the development of the drug enzalutamide by Dr. Charles Sawyers and Dr. Michael Jung, the identification of prostate stem cells by Dr. Owen Witte and colleagues, and the discovery and development of antibodies against the prostate stem-cell antigen gene, which have all gone from discovery through to clinical trials. Other highlights include Dr. Hong Wu’s work on the PTEN tumor suppressor gene, demonstrating that the gene negatively regulates prostate cancer stem cell self-renewal, proliferation and survival, and the work of Dr. Bill Aronson and colleagues demonstrating that dietary changes can affect the growth rate of prostate tumors.”
     
    According to the NCI, SPORE grants are designed to promote collaboration among the best scientific minds. The grants bring together researchers who might not otherwise have a chance to work together. The UCLA prostate SPORE is the only one in California and one of a handful in the U.S.
     
    The specific aims of the renewed grant are:
    • Conducting translational research to investigate what makes prostate cancer spread and become castration resistant, meaning that it does not respond to hormone therapy. 
    • Targeting cancer stem cells and signaling pathways.
    • Evaluating the effects and mechanisms of dietary change in preventing prostate cancer. 
    • Providing organizational infrastructure and novel technologies to support SPORE objectives. 
    • Developing new research areas and supporting the careers of new researchers.
    The SPORE grant will primarily fund four projects at UCLA:
    • Dr. Robert Reiter and Dr. Anna Wu will focus on translating N-cadherin-targeted antibody therapy into the clinic. N-cadherin, a protein expressed widely across prostate cancers, is required for castration-resistant prostate cancer to emerge and survive, and it therefore is considered a credentialed target treatment for prostate cancer by the NCI. 
    • Dr. Hong Wu and Dr. Matthew Rettig will work to advance the management of castration-resistant prostate cancer by blocking the P13K and MAPK signaling pathways. An overarching hypothesis of this project is that prostate cancer can be classified according to alterations in signaling pathways — the mechanisms that underlie the formation of tumors. Individual tumors need to be classified according to which pathways are involved and must be treated with combination treatments that prevent an alternate pathway from being activated when one is blocked. 
    • Dr. Owen Witte, Dr. Matthew Rettig and Dr. Andrew Goldstein will be focusing on prostate cancer stem cells, which are thought to be resistant to castration and most conventional therapies. Their overall rational is that optimal cancer therapy requires targeting the bulk of differentiated or adult cancer cells as well as the cancer stem cells. This project will focus on targeting a gene called Trop-2, which is present on normal and malignant prostate stem cells. This is a novel approach to prostate cancer treatment.
    • Dr. Bill Aronson and Dr. Pinchas Cohen will focus on the molecular effects of diet and how diet can help prevent and manage early prostate cancer. A previous study led by Aaronson and Cohen found that a low-fat diet supplemented with fish oil could slow the growth of prostate tumors.
    Jonsson Cancer Center director Dr. Judith Gasson, a professor of medicine and senior associate dean for research, said that UCLA’s prostate cancer program is a shining example of the campus’s excellence in interdisciplinary research. 
     
    “We’ll be able to move forward more quickly now to develop new and better ways to prevent, diagnose and treat prostate cancer with the goal of saving tens of thousands of lives every year,” she said.
     
    UCLA’s Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation’s largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2013, the Jonsson Cancer Center was named among the top 12 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 14 consecutive years.
     
    For more news, visit the UCLA Newsroom and follow us on Twitter

  • Responding When Your Expertise Is Challenged







    Deepa Purushothaman, principal at Deloitte Consulting LLP, explains why it’s important to understand how you’re perceived. 

  • Move Beyond Enterprise IT to an API Strategy

    For the vast majority of organizations, the IT function’s focus has been inside the enterprise. They might allow some occasional website browsing by employees (though many sites are banned), and perhaps an inbound website or intranet for customers to enter an order. The focus, however, has been on protecting a walled garden of information transactions.

    We think the emphasis should instead be external. Toward this end, we increasingly see sophisticated organizations competing in an “API economy” in which application programming interfaces are the primary approach to inter-organizational collaboration and information exchange. APIs, which are specifications or protocols for how to exchange information or request online services from an organization, are already booming in online businesses. As more companies realize that information is key to their product and service offerings, and that they need an ecosystem to provide those offerings, APIs will grow further in popularity. Many of today’s ecosystem members are coders and app developers, and APIs are how they interface with a provider organization.

    Netflix provides a great example of the role of APIs in a successful information-oriented business. Correlation is not causation, but there seems to be a close correlation between the growth of Netflix’s stock price and the rise in the number of API calls it gets. The latter figure is close to 50 billion per month now (from about 2 billion three years ago), which is a powerful indicator of how open the company has become. Netflix makes movie and TV content available through a variety of devices, from iPhones to PlayStations to many “smart” TVs. The company also makes available other information content to many sites, including its catalog, recommendations, and ratings. All of this content makes its way to sites and devices outside of Netflix through the magic of APIs.

    Other companies with strong API-based ecosystems include Salesforce.com, Facebook, Twitter, Google, and eBay. All have seen fantastic growth. They all needed API-based ecosystems because consumer demands are hard to predict and they use a wide range of devices. Opening up APIs lets organizations outsource innovation by allowing third-parties to experiment with their information assets and share revenue streams. They can also control usage when necessary by limiting access to partners they choose.

    However, there are other sectors that have not yet opened themselves up to ecosystems with APIs. Health care IT, for example, is a largely closed industry; health records systems like EPIC and GE Healthcare IT are protected environments, largely closed to external ecosystems. One exception to this pattern is athenahealth, a Boston-based software-as-a-service health records system company that is trying to engender a health information ecosystem. Called “More Disruption Please,” the movement has elicited a few development partners, but CEO Jonathan Bush would like to see more. RunKeeper, a tracker of fitness activities, has had somewhat greater success in building an ecosystem, but it’s more about fitness data than health information.

    Of course, an API strategy is not a binary decision — to use them or not to use them. There are public (open to everyone) and private (open only to certified developers or partners) APIs. There are free APIs (Google’s, for the most part, although they charge under certain circumstances) and flat fee or revenue-sharing ones (Apple’s, for the most part). There are information and services that you want to give your ecosystem access to, and those that you probably should keep to yourself. In short, your organization needs to debate the various elements of an API strategy, and then you need a set of governance mechanisms to enforce it.

    So if your enterprise IT is only focused on the internal enterprise, you’re already falling behind in the API economy. You need to start building an ecosystem, and APIs are the way to do it.

  • 25 songs to celebrate innovators: A Spotify playlist inspired by TEDWomen

    The Ahn Trio plays during TEDWomen 2010. Photo: James Duncan Davidson

    The Ahn Trio plays during TEDWomen 2010. Photo: James Duncan Davidson

    Inspired by the theme of TEDWomen 2013, “Invented Here,” we’ve created a killer playlist with songs about women who’ve innovated, made a difference, taken a stand and changed history in the process.

    Our mixtape of tunes include: a Swedish dance-pop tribute to Marie Curie’s research on radioactivity, Jane Birkin’s ode to the work and ideals of Burmese political prisoner Aung San Suu Kyi, an emotional love song dedicated to Georgia O’Keefe and a tongue-in-cheek punk rock commentary on Margaret Thatcher.

    Sit back, turn up the volume and have a listen!

    TEDWomen 2013 will be held in San Francisco, December 4-6, 2013, at the new SFJAZZ Center. Registration for the event opens today. Head to the TEDWomen site to find out how to apply »

    Sign up to get news and updates on TEDWomen »

    Unable to listen to the Spotify playlist? Here is a list of all of the songs we’ve included:

    Clara Barton – Country Joe McDonald
    Abigail Adams – The City and Horses
    When Frida Kahlo Lost Her Halo – Greg Douglass
    The Ballad of Marie Curie – Army Of Lovers
    Florence Nightingale’s House – Katie Malco
    Nelly Bly – Dirty Bourbon River Show
    Ada Lovelace – Madam Monom
    Sojourner Truth – Jeanne Humphries
    Amelia Earhart vs. the Dancing Bear – The Handsome Family
    Cleopatra – Miniature Tigers
    Mother Theresa Can’t Dive – Jose Vanders
    Georgia O’Keefe – Duke Special
    Benazir Bhutto’s Hands Are Clean – Muslimgauze
    Aung San Suu Kyi – Jane Birkin
    Susan B. Anthony Dollar – Sherman & Larsen
    The Ballad of Isadora Duncan – Mike Elliott
    Hypatia – Tomi Leppanen
    I’m In Love With Margaret Thatcher – NotSensibles
    Maria Montessori – With An Orange
    A Freestyle Kiss To Hedy Lamarr – Botanica
    Madeleine Albright – Dave Lowensohn
    Harriet Tubman’s Ballad – Woody Guthrie
    Joan Of Arc – Leonard Cohen
    Speeches Of Indira Gandhi – Indira Gandhi
    Jane Goodall – Adam Kautz
    Virginia Woolf – Indigo Girls
    Annie Get Your Gun – Squeeze

    Hailey Reissman, on the TEDx editorial team, contributed to this playlist.

  • TEDWomen 2013: Invented Here. Registration now open.

    Invented-Here-mainThe old saying goes: “Necessity is the mother of invention.” Folded into this truism is a nugget of wisdom: that women so often are the ones driving innovation, the creative powerhouses surfacing new concepts, and the active force crystalizing change in communities near and far. This is the spirit that TEDWomen 2013 will celebrate with its theme: Invented Here.

    TEDWomen 2013 will be held in San Francisco, December 4-6, 2013, at the new SFJAZZ Center. Registration for the event opens today. Head to the TEDWomen site to find out how to apply »

    But even if you can’t travel, you can be a part of the TEDWomen experience. On December 5, more than 150 TEDx events around the world will share the TEDWomen livestream and present local speakers with their own takes on invention and re-invention, making the day about the global experience of women.

    TEDWomen has become a powerful test kitchen for ideas. Sheryl Sandberg’s book Lean In began on the TEDWomen stage on 2010. In 2011, Jane Fonda spoke on how women can and should have a “third act.” And last year, Angela Patton — recently featured on ABC News — shared her incredible story of throwing a father-daughter dance in prison.

    Join us this December as we celebrate the incredible work of women and celebrate the inventors, designers, chefs, thinkers, makers, leaders, local problem-solvers and general dreamers of every gender who dare to imagine more.

    Find out much more about TEDWomen 2013 »

    Sign up to get news and updates »

  • One More Breaking Bad Trailer To Tide You Over Until Sunday

    Five more days. That’s not so bad, is it? I mean, what’s a 120-plus more hours when you’ve been waiting almost a year? Good thing AMC understands how these waits can hurt, and so, they’ve been releasing balms and salves to tide you over, and even though the wait is almost over, AMC has once again delivered another dose of preview material. Granted, the “Say My Name” trailer is designed to encourage the hunger, as well as temporarily satisfy your cravings, so proceed with caution. Your desire to see the new Breaking Bad may just overwhelm you if you binge:


    I’m curious to see if the premiere of Breaking Bad’s final chapter gets close to Sharknado in the tweets per minute category. Considering the show’s not currently being aired, and yet it is still a popular topic of conversation, as in at the time of this writing, it’s quite possible the return of Breaking Bad could be one of those television events that spawns follow-up articles discussing its overwhelming Twitter impact.

    If you don’t know by now, you’re probably not interested, but the final episodes of Breaking Bad begin on Sunday at 9 PM Eastern.

  • Bowler’s Perfect Game Snatched Away By Lane Malfunction

    A perfect 300 in bowling may be one of the hardest feats in sports. I’m lucky to get one strike every five games, and professional bowlers maybe get two strikes per game. One bowler managed to come incredibly close to a perfect game over the weekend, but victory was taken from him at the last moment.

    CBS Houston reports that Troy Walker, a competitor in the 2013 Luci Bonneau Doubles tournament, was on a roll with 11 consecutive strikes in his game. During the last frame, he lined up the perfect shot and let the ball loose. It was here that the pent up anger of the bowling gods must have been let loose as the rack came down right before the ball hit the pins. This obviously stopped the ball from completing its holy mission, and Walker was denied his perfect game.

    Fortunately, the tournament judges let him try again, but it was too late. Walker’s luck had run out and his last shot only knocked down seven pins. He ended up with an incredible score of 297, but that freak accident most likely cost him a perfect game.

    So, what did Walker have to say about his perfect game being snatched away by a rogue rack? He said that he may have robbed himself of a perfect game by resetting the wrong lane before he took to the floor for his final frame. That reset may have sent the rack crashing down on his lane.

    Regardless of whose fault it was, he says the story will at least give him “something to talk about.”

    Check out the video below to relive what must have a painful experience for all in attendance:

  • Riley Cooper Returns To Team, Practices

    After taking some time away from his team following his oft-documented adventures in racism at that fateful Kenny Chesney concert, Riley Cooper has officially rejoined the Philadelphia Eagles, which obviously includes him rejoining the teammates he offended with his drunken behavior. While some may be expecting some public backlash against the Eagles receiver, it appears as if another avenue is being traveled: genuine forgiveness.

    The news of Cooper’s return to the Eagles came courtesy of Chris Mortensen’s Twitter:

    As for the forgiving attitude towards Cooper, it is perhaps best captured by Peter King’s Monday Morning Quarterback column, which contains the following quote from Mike Vick, a player who knows a thing or two about public forgiveness:

    “Just because he made that one mistake doesn’t mean he can’t overcome it,” Vick said. “Or he can’t be condemned for it. Everybody deserves a second chance … Just for one second, expand your mind. Expand your mind and have supernatural thinking about it. Everything doesn’t have to be negative. Everything can be fixed. So many people forgave me. And it took time. It’s still taking time.”

    There was also an interesting point offered by ex-Dallas Cowboys receiver Michael Irvin, and while that may be somewhat unexpected, it doesn’t make his statements any less compelling, especially when he discusses the morass surrounding the infamous word itself:


    It was, however, Adam Scheffter who encapsulated the entire NFL offseason by tweeting about one simple picture he posted on his Instagram account:

    Tebow, Cooper, Hernandez

    For those who aren’t sure, that’s Tim Tebow, Riley Cooper, and Aaron Hernandez when they played for the Florida Gators. I’m sure Urban Meyer would look at that particular picture with the same kind of pride a father has for his daughter’s first recital.

    Lead image courtesy

  • Candle Magic: An Aspect To Spell Casting

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  • Consequences Of Marathon Functioning On Your Heart

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  • Data On Tv Uplink And Broadcasting

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  • The Apple Apple Iphone Four

    This idea is perplexing to some individuals. You can participate in SCVNGR everywhere! The technique invokes the Vo – IP application and also returns command more than its sockets into it after incoming audience are learned.iphone repairs

    Your fingertip is likened to a mouse cursor as you navigate your way to the features of the Storm. It need to be flawless and persuasive to use. If do you need to do one thing extra with your apple iphone, assume not far more but obtain iphone add-ons.

    From there, Android and also other platforms started copying in the pace of gentle. If at when you would like rid of it you should really just open up SBSettings, pick out Steps > Extra > Conceal Icons all over again and scroll to the sought after application and contact the tab to exchange again to ‘on’. The application is no cost, but to write-up in IOS will have to pay out a license fee of $400 or $1500.

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  • Understanding Well Being Insurance Coverage Reform

    Health maintenance organization plans (HMO) are what is generally referred to as a managed care plan.

    liability insurance Generally speaking, their raison d’tre is that sustaining your good health is possible by preventing illness and supplying the best of treatment. If you take this 1 stage further, with great well being and operating to keep things that way, the increasing costs of well being treatment throughout the country might be managed, if not decreased.

    Healthcare insurance coverage costs can be altered by choosing on coverages you want to exclude or include-on. Eyesight and oral insurance coverage are frequently suggested, and you will moreover figure out how a lot you want to co-spend out or offer with from spending budget. Keep in mind that much more rewards similar an elevated top quality and vice versa.

    When choosing well being treatment insurance coverage, get acquainted with the local limitations and regulations. For instance, your legal guidelines may possibly provide defense when you have preexisting medical conditions. If you are mindful of the health care insurance limitations along with your reputable privileges, you might steer clear of health treatment insurance coverage companies who are trying to cost a charge for unfinished safety.

    It is usually desirable to begin early and purchase insurance coverage before you reach the age of retirement. The earlier in life – say 20s or 40s, the much better it is for you to get favorable terms by the time you retire and are faced with serious health care expenses. Start early and you can pay lower rates and get the complete benefits. Buying health insurance after retirement can be a tough task, even though a few insurance coverage businesses have started underwriting for seniors with conditions like high blood stress, higher than regular cholesterol levels, etc. Not all insurance companies have this kind of choices.

    When you discover yourself obtaining medical well being insurance coverage, it is important to be educated about polices or regulations and regulations regulating medical insurance coverage that might affect you. Does your status provide safety for preexisting well being issues? Knowing about rules this kind of as these is essential which indicates that your medical insurance company is looking for to refuse you formally appropriate insurance.

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  • Healthcare Alarm Unexpected Emergency Alert Button

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  • Turn Out To Be Much More Alert And Smarter With Piracetam

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