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  • Video: Ben and Dion Present at Stanford

     

    Since joining Palm back in September, Ben Galbraith and Dion Almaer have really been accomplishing a lot (dare I say kicking ass?) in roles as Directors of Developer Relations.  In addition to the Developer Day (where at, of course, and will be keeping you up to date on the latest happenings) and the on-going podcast series, the two have been giving a 10 week crash course on the future of the web and mobile at a little college in Palo Alto called Stanford University.  The school, along with Palm, are making the videos available online for your learning pleasure.  Currently on week two class, the first class gives a higher-level overview of mobile and the mobile Web, and the latest video covers some HTML/CSS/JavaScript fundementals (you know, the technologies you need to build applications using Palm’s SDK.)

    So while you’re kicking yourself for not heading to Sunnyvale this past weekend, cue up the Stanford videos (which are about 50 minutes in length) and get your learn on.

  • Jawbone ICON: Now Supports Bluetooth Music, $96.95

    The Jawbone Icon Bluetooth headset has a new feature: A2DP Bluetooth Audio! The feature is available as a download from Jawbone’s MyTalk software updates.

    The PreCentral.net Accessory Store is currently selling this best-of-breed Bluetooth headset for the reduced price of only $96.95.

  • Amazing Shuttle picture! | Bad Astronomy

    “Amateur” astronomer Ralf Vandebergh took this incredible shot of the Space Shuttle Orbiter Discovery as it was docked to the space station. Mind you, this picture was taken from the ground!

    vandebergh_sts131

    Wow! Discovery was 369 km (220 miles) away from Ralf when he snapped this shot using his 25 cm (10″) telescope. The atmosphere above his observing site was calm and steady, aiding him in getting such an astounding picture. Incredibly, he was tracking the Orbiter and station manually, moving his telescope by hand!

    He has other pictures of this mission as well, including several of the space station. Ralf’s images have graced this blog before, including this one of the station, a picture of Discovery and ISS from an earlier mission, and one actually showing an astronaut doing a spacewalk!

    It’s easy to forget that space isn’t all that far away, starting (officially) only 60 miles above our heads. The ISS orbits just 350 km (210 miles) above the Earth’s surface… which may not seem like much. But that’s vertical height; imagine climbing a staircase that high! It takes a lot of energy to get there, but, as it happens, only about the same amount of energy once there to go anywhere in the solar system.

    As author Robert Heinlein said: once you’re in orbit, you’re halfway to everywhere. All it takes is energy, and the will to go there.


  • What Goldman Should Tell the Senators

    The early questioning in the Senate’s hearing on Goldman Sachs centered on the following question: do broker-dealers have a fiduciary duty to act in the best interest of their clients? Both Senators Carl Levin (D-MI) and Susan Collins (R-ME) wanted an answer to this question. They didn’t really get what they wanted. It’s unclear why, however, because the bankers testifying certainly could have appropriately answered the question.

    That answer is related to a post from yesterday, which explained a banker’s fiduciary duty. The answer is yes and no, depending on what you mean by “best interests.” As a market maker, an investment bank does have a duty to act in the best interest of their clients, but not the way the Senators are looking for. They think Goldman should have informed its clients of its world view of how the market might perform in the future.

    Market makers need to provide clients with fair market pricing along with full and accurate information about the securities that they’re selling. Goldman was not acting as an investment advisor in the examples the Senators used. As a result its bankers should not have provided clients with their opinions on the future performance of those securities.

    Megan McArdle explains one reason why: because Goldman’s opinion doesn’t much matter. Large sophisticated investors have their own assumptions and beliefs about the market. They would be crazy to assume Goldman is always right about the future. Even the brilliant bankers within the walls of its 85 Broad Street headquarters get things wrong from time to time.

    There’s another important reason why Goldman — or any other broker-dealer — couldn’t act in the best interest of its clients in the sense the Senators wish, however. It would literally be impossible. Much of investing is a zero-sum game. There are two sides to each bet. For a bank to favor one party over the other, then it would necessarily harm one of its clients. If it has an opinion adverse to one investor’s interests, then it would be doing that investor a disservice by providing that opinion to the other party.

    That’s why all an investment bank can do is present full information to all investors and allow them to decide whether or not to buy a security. At one point Collins states that Goldman’s clients weren’t just paying big fees for efficiently conducting transactions, but for their “judgment as well.” That’s simply false. And any investor who thought Goldman put its stamp of approval on any security it sold would have been incredibly foolish.

    Collins went on to suggest that Congress should impose a clear fiduciary duty on broker-dealers. Presumably, she means in the way she suggests — where a broker-dealer’s judgment on a security it sells matters. For the reasons explained, that would be completely nonsensical, because it would make a marker-maker’s job impossible. It should remain neutral on performance, and unite investors on both sides of a trade at a fair market price.

    It’s unclear why Goldman’s bankers aren’t just carefully explaining this point. Their allusive techniques, which include taking as long as possible to reply to questions, providing vague answers and failing to “recollect” various things, simply makes them look worse. But it does begin to show why so many Goldman alumni find their way to Washington — they sound more like politicians than bankers.





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  • Gold Priced In Euros Soars To New Nosebleed Highs

    Check out the price of spot gold when priced in euros. It’s soaring to new highs thanks to S&P’s downgrades of Spain, Portugal, and Greece.

    This chart goes to yesterday. The chart below it shows it blasting ever close to 880 in today’s action.

    10 year Euro Gold

    euro gold april 27th

    Join the conversation about this story »

  • Mexico president criticizes Arizona immigration law

    [JURIST] Mexican President Felipe Calderon on Monday strongly criticized Arizona’s new immigration law, claiming that the measure opens the door to intolerance and hatred. The Arizona bill, signed into law last week by Governor Jan Brewer, makes it a crime to be an undocumented immigrant and requires police to question anyone whose immigration status appears suspect. Calling the law a violation of human rights, Calderon promised that it will be a pressing item on his agenda during his upcoming visit to Washington in May. Calderon has also called on Mexico’s foreign ministry and consulates in the US to begin defending the rights of Mexicans and suggested that trade and political ties between Arizona and Mexico will be seriously affected.
    Two Latino advocacy groups have said they plan to challenge the constitutionality of Arizona’s new immigration law, alleging it permits racial profiling. Officials from the Mexican American Legal Defense and Education Fund (MALDEF) and the National Coalition of Latino Christian Clergy contend the law will let police single out minorities for immigration inspections. US President Barack Obama has also criticized the law, calling for federal immigration reform. Under the law, it is designated a crime to be in the country illegally, and immigrants unable to verify their legal status could be arrested and jailed for six months and fined $2,500.

  • Obama’s deficit commission and the politics of crisis

    Good luck to the Obama deficit commission. In my heart, I do not believe Congress will pass huge entitlement cuts (preferable)  or tax increases without a  crisis.  (There needs to be a focus on boosting economic growth.) To quote Milton Friedman in Capitalism and Freedom:

    Only a crisis—actual or perceived—produces real change. When that crisis occurs, the actions that are taken depend on the ideas that are lying around. That, I believe, is our basic function: to develop alternatives to existing policies, to keep them alive and available until the politically impossible becomes politically inevitable.

    Here is one crisis scenario, as outlined by the Committee for a Responsible Federal Budget:

    If low interest rates lead to continued debt accumulation and then suddenly, creditor preferences shift, we could experience a “catastrophic budget failure” as set out in a recent paper by Len Burman of the Maxwell School at Syracuse University and his colleagues at the Tax Policy Center.

    Under this scenario, at some point financial markets or foreign lenders decide we are no longer a good credit risk, possibly due to debt affordability concerns. They conclude the United States cannot escape basic economic and financial “laws of gravity” forever. They stop buying our debt securities or demand dramatically higher interest rates due to increased perceived risk. With the sudden shift and large rise in interest rates, the economy goes into a severe recession. (“The longer it takes for the crisis to occur, the worse it will be.”) Unlike the past two years, we cannot, however, borrow to stimulate the economy because the crisis was caused by excessive debt and lost confidence. “In the extreme case, the U.S. may not be able to borrow at any interest rate.” Creditors concerned with hyperinflation or even default will not buy U.S. debt.

  • Interview with Mario Batali

    media_marioMario Batali — the chef who has done more to change the look and feel of Italian cooking in this country than anyone in 20 years — will be coming to Atlanta this weekend. Not to scout out a place to open a restaurant, alas, but to demonstrate recipes from his new cookbook, “Molto Gusto: Easy Italian Cooking” (Ecco, $29.99), at the Metropolitan Cooking & Entertaining Show at the Cobb Galleria Centre. Batali and his partners run 14 restaurants in New York (his home base), Las Vegas and Los Angeles, and are gearing up to open two more in a Singapore casino. He has authored several cookbooks and is a regular performer on the Food Network program “Iron Chef America.”

    We spoke on the phone briefly:

    Q: What are you planning to demonstrate?

    A: Really this book is all about the simple and predominantly vegetable-based foods of the Italian daily table. So I’m planning to make a dish of cavolo nero (Tuscan kale) with ricotta thinned with olive oil and water — it’s like a thin soup. And …

  • Do You Eat Chocolate to Relieve Depression–or Does Chocolate Make You Depressed? | 80beats

    iStock_000008675082XSmallScientists have long suspected that a link exists between mood and chocolate, as studies (done primarily with women) have suggested that eating a chocolate bar temporarily banished the blues. Now a study has brought new complexity to the issue with its finding that depressed people consume larger amounts of chocolate. But researchers are no closer to figuring out which factor is the cause and which is the effect: Do glum people reach for a Hershey bar to lift their spirits, or is the chocolate actually bringing them down?

    For this study, researchers at the University of California studied 931 men and women who weren’t on antidepressants and quizzed them on their chocolate-chomping habits. Then, using a standard screening survey, they assessed the volunteers for symptoms of depression. The scientists found that those who were the most blue consumed the most chocolate.

    This held true for both the men and the women; people who were depressed ate an average of 8.4 servings of chocolate per month, compared with 5.4 servings among those who were not depressed [Reuters]. Those who scored highest on the mood tests, indicating possible major depression, consumed an average of 11.8 servings per month [Los Angeles Times]. The findings led the research team to conclude in the Archives of Internal Medicine that “depressed mood was significantly related to higher chocolate consumption.”

    While the study established a link between chocolate eating and depression, the researchers could not pin down how the two things are related. The authors suggest that depression might stimulate chocolate cravings, and that people might reach for a candy bar to self-medicate; chocolate prompts the release of certain chemicals in the brain, such as dopamine, that produce feelings of pleasure [Los Angeles Times]. But it’s also possible chocolate only provides a short-term lift, and that over time, it contributes to depression. Yet another possibility is that a separate physiological mechanism, like stress, is responsible for both depression and an appetite for chocolate. With this cloud of uncertainty hovering over the candy isle, chocoholics will be eagerly awaiting further studies.

    Related Content:
    80beats: The First Chocoholics: Native Americans Imported Cacao From 1,200 Miles Away
    80beats: Rats Fed on Bacon, Cheesecake, and Ding-Dongs Become Addicted to Junk Food
    80beats: Are Women’s Brains Hard-Wired to Have Trouble Resisting Temptation?
    80beats: For Obese Women, a Milkshake Brings Less Pleasure to the Brain

    Image: iStockphoto


  • Jesse James’ Lifelong Obsession With Nazism

    Jesse James’ father, Larry James, isn’t surprised that the biker’s idea of a good time is bedding Neo-Nazi strippers and posing as an officer of the German militia. Dad says his son was fascinated by Hitler even as a small child.

    “He did have a fascination with the Nazis, and it did start at an early age. He liked their war machine, he liked their uniforms, he liked their guns, he liked everything about them.”

    Larry also charges Jesse with severing ties with his family six years ago to conceal the truth about his past.

  • Gov. Rell Commits To Appointing Minority Candidate In Coming Months; Breakthrough At Judiciary Committee

    After days of clashes and deadlock that brought the state Capitol to a complete standstill, the legislature’s judiciary committee began voting Tuesday on Republican Gov. M. Jodi Rell’s batch of nominees for Superior Court judgeships.

    The breakthrough came after Rell said she is committed to nominating more members of minority groups to the bench.

    Rell’s spokesman, Rich Harris, said Tuesday that Rell intends to be “appointing a qualified, approved minority candidate to the bench in the coming months, following a thorough and rigorous recruiting and vetting process. Connecticut is a state rich in its racial, ethnic and social diversity, and that diversity should be celebrated.”

    One of the problems, Harris said, is that only 4 percent of the candidates on the official list for judgeships are members of minority groups.

    Rep. Michael P. Lawlor, the longtime co-chairman of the legislature’s judiciary committee who has often clashed with the governor’s office, said, “I’m delighted about the outcome of this. We all have an obligation – all of us – to reach out … by trying to encourage people to get involved.”

    Lawlor encouraged attorneys to take the first step in becoming a judge by downloading an application from the Judicial Selection Commission, which is available online.

    Lawlor’s co-chairman, Sen. Andrew McDonald, said the committee did not have sufficient information on which lawyers are on the list in the highly secretive process. While Rell’s nominees have been placed under the spotlight over the past week, McDonald said the issue is much broader than the most recent group of nine nominees.

    “We have a lack of diversity in law schools,” McDonald said. “We have a lack of diversity in our municipal law departments around the state. … I can guarantee you that these nominees, if they are approved, are going to be more sensitive” about issues of diversity in the years ahead on the bench.

    The first committee vote Tuesday came on John L. Carbonneau, an unaffiliated voter and labor lawyer from East Lyme who attended the University of Connecticut as an undergraduate and later received his law degree in 1980 from the Catholic University of America. While the votes are still open until the committee meeting ends, both Democrats and Republicans voted in favor of Carbonneau.

    State Rep. Kenneth Green, a Hartford Democrat, said he is still unclear what criteria are used to determine whether someone is qualified to earn the judge’s robes. Overall, 38 attorneys applied last year, and 24 were rejected, he said.

    “I am still very uncomfortable with the process of the Judicial Selection Committee,” Green said. “As an African American male, I was deeply disappointed of not having anyone of color on the original list” from Rell.

    Green voted against Carbonneau, but state Rep. Ernie Hewett of New London – who had raised questions recently about racial diversity – voted in favor.

    Green said he still has “some very serious concerns” about Republican Laura Flynn Baldini, a Yale-educated lawyer from West Hartford with 12 years of experience at the bar. At 39, Baldini is the youngest of Rell’s nominees and has come under fire for lacking the experience of Rell’s other nominees, including six who are at least 54 years old.

    “I think her testimony demonstrated that she is not qualified to be on the bench,” Green told his colleagues early Tuesday afternoon.

    But Rep. Kevin Roldan, a Hartford Democrat, immediately defended Baldini – saying that he knows her well as “an intelligent individual, a thoughtful individual” who deserves the committee’s support for a judgeship.

    Sen. Edwin Gomes, a Bridgeport Democrat, said he agreed with Green on the overall issue – saying that Green represented the thoughts of the majority of the Black and Puerto Rican Caucus. Gomes said that Baldini did not answer the questions well during her testimony on Friday night, prompting him to vote against her nomination.

    Rep. Toni Walker, a New Haven Democrat, and others said that a high number of those in the criminal justice system and in prison are members of minority groups. The judges, however, largely are not.

    “It has been a very, very tough road of the last few days,” Walker said. “We have two Connecticuts here, and it’s been wider and wider. … The two Connecticuts have to stop. … We have to have a better system. … If you cannot empathize, then don’t obstruct. You may feel it’s not in your neighborhood, but eventually it will be.”

    “The system is broken. Something is wrong,” said Hewett, the father of three children. “When everybody else does 50 percent, you have to do 150 percent just to survive. … I hated what we had to do yesterday, but we had to get people’s attention.”

    He added, “It’s about personalities. … Why don’t we just go and change the system and pick who you like?”

    Sen. Edward Meyer, a Guilford Democrat and longtime attorney, said, “This issue is not just an issue for the Black and Puerto Rican Caucus. This is an issue for all of us.”

    But Rep. Themis Klarides, a deputy House Republican leader, said, “When we talk about minorities all the time, does that include women? As women, we are minorities, technically. Sometimes, it’s confusing to me. … I want to make sure we understand that minorities covers a whole plethora of groups.”

    The question over having enough minority nominees on the bench goes back more than a decade for a period covering the past three governors and the past four House Speakers. In the 1990s, then-Rep. William Dyson of New Haven and others pushed hard for more representation and spoke about it on the House floor.

    State Rep. Arthur O’Neill, a Southbury Republican, said that 85 percent of Gov. John G. Rowland’s judicial appointees were white, and 81 percent of Rell’s appointees have been white.

    “If you’re not sitting at the boardroom table, sometimes you have to bang on the boardroom door to be heard,” O’Neill said. “There needs to be a more aggressive recruitment effort. I’m not going to ask members of the Black and Puerto Rican Caucus how many people they have gone up to and asked them to be judges.”

    Sen. John Kissel, an Enfield Republican, said he wanted to commend the members of the caucus for their efforts during a public hearing Friday night.

    “There were no inappropriate questions. They were all on point,” Kissel said. “I know what it’s like being a minority – as a Republican in this building in the last several years” in a Capitol where Democrats hold veto-proof majorities in both chambers. “We have a defining moment now to turn a corner.”

    But Rep. William Hamzy, an attorney who serves as a deputy House GOP leader, said it is a “dangerous” path to equate the number of minorities in prison with the lack of minorities on the bench.

    Rep. John Hetherington, a New Canaan attorney, said, “She has certainly the intellectual strength to become a very fine judge. Judges don’t come to the bench completely formed. They are built by the experience. … She’s young and necessarily of lesser experience, but I have no doubt about her.”

    Hetherington mentioned that former U.S. Supreme Court Chief Justice Earl Warren, who wrote the majority opinion in the landmark education ruling of Brown vs. Board of Education in 1954, had very little judicial experience when he came to the bench.

    Rep. Patricia Dillon, a New Haven Democrat, said, “It’s been wonderful to watch this process. It’s been great democracy. … I do think we’ve fallen behind. That’s simply true. … We’ve also voted on some people with pretty thin resumes who were inside players.”

    Dillon said she was sorry that the nominees had been “caught up in forces that are much bigger than themselves” and witnessed multiple delays in the process.

  • First-ever Survey Tallies Green Jobs in California

    California's Employment Development Department (EDD) recently released a tally of green jobs in the state. The total? Nearly half a million workers spend at least half or part of their time on green products or services, according to the first-of-its-kind survey of 15,500 employers. The goal of the study was to establish baselines of green employment and green business practices in California.

    Jobs considered green are those that are categorized using the GREEN model:

    • Generating and restoring renewable energy
    • Recycling existing materials
    • Energy efficient product manufacturing, distribution, construction, installation and maintenance
    • Education, compliance and awareness
    • Natural and sustainable product manufacturing

    Top green employers are in recycling (25%), energy efficiency (24%) and sustainable product manufacturing (22%). Within these categories, manufacturing and construction industries have the most green jobs. This is a bright spot in sectors that have taken a hit during the recession.

    Thanks to groundbreaking measures such as California’s landmark Global Warming Solutions Act, companies have been able to maintain and grow their green workforce during the recession, even in industries that have suffered nationally.

    Industries with Most Green Jobs in California (as of 4/2010)

    Southern California stands out as the regional green jobs leader. It accounts for nearly half of California’s total green employment, followed closely by the San Francisco Bay Area, which boasts more than 130,000 green jobs. The rest of California’s green jobs are spread throughout the state's remaining seven regions. Although the type and number of green workers vary greatly by region, this latest study confirms that California has the largest green economy in the country.

    Another key finding: 63% of businesses surveyed use at least one sustainable business practice. A total of 80% recycle, 50% use recycled products and nearly 40% use energy efficiency practices. It is safe to say that California businesses understand that good environmental strategy is good for their bottom line. 

    On-the-job training is the method most often used (75%) by companies to prepare workers for green jobs, with in-house classroom training coming in second. Others use training programs offered at community colleges or by vendors.

    For workers who are interested in joining California's growing green economy, we recommend a few simple steps to get started. First, look at industry market trends to identify existing and future opportunities. Based on this survey, the top three areas of green expertise for which firms are expected to be hiring for in the near future are waste minimization, energy conservation and information technology. The survey also breaks down job types by region, which can be used to focus a job search based on where the most opportunities are.

    Second, research available off-the-job training programs. The largest state-sponsored one is The California Clean Energy Workforce Training Program, which has a website with links to valuable resources. Green for All also has a web site with links to green jobs listings.

    EDF will soon launch an online green jobs portal to help connect job seekers to training in these and other areas of expertise. Featuring a searchable green jobs training map, a digitized version of our Green Jobs Guidebook, and in-depth profiles of real people working in California’s green industry, EDF’s portal will help job seekers plot their green career path. This is the latest addition to EDF's mapping of the green economy in California that shows how 2000+ companies are benefiting from the state's leadership on fighting climate change and transitioning to a clean energy economy.

    California has the largest green economy in the country. In a period when unemployment is up to nearly 10% nationwide and many local jobs are going overseas, this survey confirms that California is reaping the economic benefits of strong energy and climate policies.

  • FDA Gives Digirad OK to Market Ergo Device

    Bruce V. Bigelow wrote:

    Digirad (NASDAQ: DRAD), a medical imaging company based in Poway, CA, says it got regulatory approval to market Ergo, a new nuclear imaging camera system for hospitals. Digirad CEO Todd Clyde tells the San Diego Union-Tribune that what sets the solid-state camera apart is its field of view and its portability, which means patients won’t have to be wheeled from their hospital rooms to get scanned.

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  • Gut Flora and Your Healthy Immune System

    bacteriaLast week, I discussed the importance of gut flora in the digestion of food while briefly touching on its role in early immunity, including the development of asthma and eczema – both of which are immune issues that appear to be exacerbated or caused by disrupted gut flora in children. But it goes much further than “just” asthma and eczema. Our gut flora plays a massive role in mediating our entire immune response. Think about this little factoid: the human gastro-intestinal tract houses the bulk of the human immune system, about 70% of it. And foreign gut flora actually aids and abets our innate immune response system by improving the function of our mucosal immune system and providing a physical barrier to invading microbiota. Before I get into that, though, let’s go over what we mean by immune system.

    Some time back, I wrote a post discussing the three tiers of the human immune system:

    1. Anatomical barriers – Skin is the basic line of defense, along with mucus membranes and other physical responses like sweat, tears, and salivation, against the intrusion of foreign bodies and antigens.
    2. Innate/non-specific immune system – The innate immune system is the broad, generic response to bacteria and viruses that have made it past the anatomical barriers. Imagine bacteria entering through an open wound and the resultant inflammation, which is pretty much the body’s attempt at a catch-all response. Technically, the physical barriers are included in the innate system.
    3. Adaptive/specific immune system – The immune system can learn and improve its response to specific microbes over time and with repeated exposure; this is the adaptive immune system, and it’s only present in jawed vertebrates.

    It’s generally accepted that gut flora affects and informs our immune systems, and how it does so, though a complicated, multi-faceted process, is beginning to be teased out by researchers.

    Intestinal flora helps determine the quality of our mucosal immune system in several ways. First, it provides a physical barrier to colonization by foreign, deleterious microbes. As I mentioned earlier, infants receive the lion’s share of their gut flora from the mother (and surrounding environment) during birth and for the first year or so. This is a crucial time, because the first bacteria to gain a foothold are able to establish a long-lasting, mutually beneficial relationship with the host (that’s us). Good bacteria settles in and keeps bad bacteria out – for life (ideally, barring disruption of the population by poor diet and excessive antibiotic usage), which is why early intestinal colonization is so incredibly important for healthy function later in life. Though we’re talking tiny, invisible organisms, living quarters in the gut are still finite, and there are limits to how many microbes can be established. Compromised gut flora populations, for example, can allow harmful yeasts and bacteria to flourish. Healthy gut flora populations protect against invading microbes by simply taking up space and generally being more proficient at obtaining nutrients than the intruders. They’re playing defense, and informed, experienced defenders who know their way around always have the advantage.

    Next, intestinal flora communicates with certain features of the immune system to help them focus on invading microbes. Ever wonder how our immune systems determine which bacteria to attack and which to ignore? After all, foreign microbes are foreign microbes, and immune cells aren’t “intelligent.” There’s got to be a mechanism behind it, some sort of “safe word” that causes immune cells to pass over the trillions of foreign bacteria residing in the gut. Good bacteria talks to the lymph nodes and provides a safe word, and the lymph nodes’ stromal cells produce “normal cell” antigens that tell the immune system not to attack the good bacteria. This conserves resources and improves the immune response by making it more efficient.

    Intestinal flora can even influence the growth and formation of organs crucial to proper immune function. Take the thymus, for example, the primary function of which is to produce T-lymphocytes, also known as T-cells. T-cells are a type of white blood cell that has two functions. Killer T-cells destroy the body’s own cells that have been infected by viruses or bacteria; this prevents the offending microbe from replicating and causing more damage. Helper T-cells stimulate the production of antibodies. Both are vital, and both are made possible by the thymus. The thymus, in turn, is dependent on intestinal flora: formula-fed infants have smaller, less productive thymuses than breastfed infants. Okay, but how do we know that it’s the bacteria in breast milk making a difference? What’s one big thing that sets breast milk apart from formula? Beneficial bacteria, specifically Bifidobacteria, which is only present in breast milk. One recent study confirmed the effect of bacteria on thymus size when it compared thymus sizes in breastfed infants, standard formula-fed infants, and infants fed a fermented formula populated with Bifidobacteria. Infants given standard formula had smaller thymuses than infants in the other two groups; thymuses in infants given the fermented, bacteria-rich formula were similar in size and function to breastfed infants.

    The study (PDF) of germ-free mice offers clear evidence that the presence of intestinal microbiota impacts the development of immune systems. Mice raised in isolation chambers, completely free of gut flora, exhibit a host of immunodeficiences: systemic lymphopenia, or low levels of lymphocytes, a kind of white blood cell extremely important to immune function; hypoplastic, or underdeveloped, lymphoid structures with compromised immune function; and poorly formed high endothelial venules, which are crucial pathways for the normal immune cell response. Colonization of germ-free mice with normal levels and species of gut flora, for the most part, normalizes immune function and structure.

    90% of cells in the human body are microbial; a mere 10% are “human.” Perhaps it’s time we start redefining exactly what it means to be human. We couldn’t function without foreign gut flora. We’d be quivering and helpless, chronic hypochondriacs by necessity. Any variance in diet would probably immobilize us, and the mildest, gentlest pathogen would have its way with our tender bodies. It would be a bad scene all around.

    Every organism – at least the larger, multi-cellular ones – has similar relationships with foreign microbes. The difference with humans is that we are consciously aware of their existence, and we devise methods to eliminate them from our bodies and our environment. Wild animals do not fret about such things; they live in ignorance of the teeming bacterial hordes handling the internal machinations. Oh, they may have protectionist instincts, like shying away from harmful or spoiled food, but they aren’t making the conscious decision to avoid bacteria. We have antibiotics, and soap, and surgical gloves, and gas masks. Our entire modern existence can perhaps be described as the avoidance of nature. Nature’s a scary place, with dark, dismal caves, dangerous predators, poisonous plants, and uncertainty, so we built walls, planted crops, tamed animals, and discovered fire. Humans are of “mother nature,” but we number in the billions only because we rejected and excluded her. And that’s the tricky part of being human, isn’t it?

    Clearly, the best path for proper immunity is the early establishment of a healthy population of gut flora, ideally initiated immediately after birth. If you’re reading this, you’ve most likely been born, probably for quite some time now, but that doesn’t mean you should throw in the towel. On the contrary, we adults, more than anyone else, need to know the importance of gut flora. If we have children, it’s up to us to ensure they receive the proper exposure to beneficial bacteria. As for adults, the avoidance of sugar, vegetable oils, and lectin-rich grains and legumes to the inclusion of animal fat, protein, Primal starches, and leafy vegetables is a safe way to promote a healthy gut. Eating fermented foods and trying probiotic supplements may also help.

    For anyone who’s still interested in this subject, I’d strongly advise you check out Dr. Art Ayer’s fantastic blog, Cooling Inflammation. Art suggests chronic, systemic inflammation stemming from disrupted gut flora as the root of most, if not all, diseases. He may be onto something here.

    Let me know your thoughts in the comment board. Thanks for reading!

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    Related posts:

    1. 10 Things You (Likely) Don’t Know About Your Immune System
    2. Dear Mark: Sugar as Immune Suppressant
    3. What’s Up With Your Gut? – Beneficial Bacteria and Good Digestive Health

  • Kerry says climate bill is not dead

    by Agence France-Presse

    WASHINGTON—Sen. John Kerry (D-Mass.) said late Monday that efforts to craft sweeping, comprehensive legislation to combat climate change were still “very much alive.”

    “We’re still pushing, we’re still talking, we’re still fighting, it’s very much alive—and I won’t quit,” Kerry said in a post on Talking Points Memo.

    His comments came after Republican Sen. Lindsey Graham (S.C.), who had been working on the bill with Kerry and Sen. Joe Lieberman (I-Conn.), backed away from it in protest over a decision by Democratic Senate Majority Leader Harry Reid to move first on an immigration bill.

    “It’s practically a rite of passage. No serious legislation ever makes it very far in Congress before it’s declared dead—at least once, sometimes two or three times,” Kerry said.

    Kerry praised Graham for having “invested enormous amounts of time” in the effort to do “the hard, grinding work” on the compromise legislation.

    The House of Representatives passed its version of the bill last year, creating a cap-and-trade program that would set a limit on greenhouse-gas emissions and create a market for trading pollution rights.

    The Senate bill was to have set a price on carbon pollution and promoted offshore oil drilling, new nuclear plants, and development of renewable energy sources and other “clean” technologies to wean the United States off oil imports.

    Related Links:

    Senate Dem leader vows action on both climate and immigration

    14 buildings compete to be the Biggest Loser (of energy waste)

    Engineers plan underwater dome to contain Gulf oil spill






  • World War

    World War™. It’s the year 2012. A nuclear war has broken out. 5 countries have emerged as the major superpowers in the devastating war. Which one will you be? Massively Multiplayer ONLINE War Game! Join over 2.8 million players! Battle other players LIVE!

    Price: Free

    Place your code in the comments below! AndroidTapp.com is playing too add us: F4JWB9

    AndroidTapp.com Android Game Review:

    Pros & Cons:

    Pros

    • Fun and addictive game loaded with features
    • Hours of on-going strategic play
    • Multi-player against other World War players, plus invite others

    Cons

    • May not be initially intuitive, poke around and complete missions to learn more (or read/watch this review)

    Features:

    World War Android Game is a fantasy role play game where you start out a soldier and work your way up the ranks completing military missions assigned to you. Promote ranks and reputation by attacking other World War players, buying Units; military personnel, bunkers, defense towers plus land, air and sea war crafts. Buy Buildings that either help Energy, Defense points or earn cash from income. Invite friends to join your army by sharing your code. What may seems non-intuitive initially turns out to be a fun and addictive game that spans days of game play!

    As you advance levels it becomes more difficult and even time consuming to continue advancing so use your cash and Honor points wisely. Watch your Health, Energy and Ammo; you can pay the infirmary boost health, show The President loyalty and he can refill Energy, Stamina or Health from the Honor Points you collect. Don’t keep too much cash on you, if attacked by another player and you lose you could lose some money too. Either invest in units, buildings or deposit in the bank (note: 10% fee will be taken from deposits). Battle other players/countries to gain more money and battle stripes.

    Video Review: World War

    http://www.youtube.com/watch?v=0W7nTbc0Yqk

    World War Splash Screen
    World War Briefing Room
    World War Dashboard
    World War Missions
    World War Battle
    World War Units
    World War Buildings
    World War Recruit
    World War Health
    World War President Honor Points
    World War Skills
    World War Vault

    Fun Factor & Addictive:

    For many, the game is fun and addictive (a good time-waster)… evident with nearly 3 million players globally. FRP style games by natural receive an unusually high following.

    Graphics:

    The game board has a cool theme, however it is not intuitive in some navigation. The best way to learn it is to poke around and tap every option to find out what it does. Don’t worry, if you play this game you’ll have time to discover as advancing with low energy or stamina is not possible unless you wait out some of the timers below each.

    Accelerometer, Vibration & Sound:

    The game has sound effects which can be toggled.

    AndroidTapp.com Rating

    AndroidTapp.com Rating!AndroidTapp.com Rating!AndroidTapp.com Rating!AndroidTapp.com Rating!AndroidTapp.com Rating! (4.4 out of 5)

    Should you Download World War? Yes! Conquer Enemies and Gain the Respect of The President!

    Algadon Free Online RPG. Fully Mobile Friendly.

  • GLEE to the Googlers

    Somebody found this blog by googling, “mud mambo mushrooms.”  I suspect somebody did it just to have fun with me. Thanks, I’m touched. Somebody also found this blog by googling, “Scaletta waste hauling.” They must have heard about my exclusive litter box duties since my wife is pregnant. Let me tell you, it’s no picnic… even if both are sometimes invaded by ants. And somebody found the blog by googling “Mamba Point Book,” and now we are cooking with oil. Click through to the Mamba page to find out more about that. It now features its first blurb quote, from a bestselling author.

    Now, on the flip side, I get google alerts for “Kurtis Scaletta” that are Italian bloggers and entertainment sources talking about Glee, a show I confess to watching. There’s a young man named Kurt on the show and since “scaletta” seems to be Italian for “playlist” (which just makes me wish Kurtis was Italian for “infinite” — rather, it is Indian for “shirts”), one supposes that those Italian Glee fans might stumble across these muddy mambas trying to figure out what songs Kurt will sing on Glee tonight. So I googled back at the problem to find out what the moppet would be singing tonight, and have learned via Vanity Fair that it’s “kind of a political song from thr 1980s.” All right, folks, you have approximately 8 hours to speculate about what that song will be. 99 Luftbalons? Relax, Don’t Do It? Nineteen? Land of Confusion? First We Take Manhattan? World Leader Pretend? Ooh, how about Everybody Wants to Rule the World?

    You tell me.

    Filed under: Miscellaneous Tagged: GLEE

  • Settlement Over Seroquel Reached for $520M with Dept. of Justice: Report

    AstraZeneca has agreed to pay the U.S. government $520 million to settle charges over Seroquel, resolving a federal probe that accused the drug maker of illegally promoting their popular antipsychotic medication for non-approved uses.  

    The settlement over Seroquel is expected to be announced Wednesday by the U.S. Department of Justice (DOJ), according to a report by the New York Times. AstraZeneca will not admit to wrongdoing in the settlement, and will enter into a corporate integrity agreement with DOJ.

    Seroquel (quetiapine fumarate) is an atypical-antipsychotic that is a top selling drug for AstraZeneca, generating nearly $5 billion a year in sales. Originally approved by the FDA in 1997 for the treatment of schizophrenia, it has been frequently prescribed off-label for uses that were not approved as safe and effective at the time, such as anxiety, obsessive dementia, compulsive disorders and autism.

    While doctors are free to prescribe approved medications for non-approved uses, drug makers are barred from promoting or encouraging such “off-label” use. Since it was approved, Seroquel has been used by more than 19 million people worldwide, and some people have estimated that at one time as much as 70% of all seroquel prescriptions were for unapproved uses.

    According to internal company documents uncovered through Seroquel litigation, off-label promotion of the drug has been a key marketing strategy for AstraZenca since at least 2000. During pretrial proceedings in lawsuits over Seroquel filed by consumers who developed diabetes and other health problems after using the drugs, company papers were released that had the stated objective to “continue to encourage off-label use of Seroquel for the treatment of bipolar disorders through publications presented at major congresses,” even though treatment of bipolar disorders was not approved at the time.

    The company first announced it had reached an agreement in principle to settle the Seroquel case with the DOJ in a November filing with the U.S. Security Exchange Commission (SEC).

    In addition to the federal probe, AstraZeneca faces an estimated 26,000 Seroquel lawsuits in state and federal courts throughout the United States involving allegations that the drug maker failed to adequately warn about the risk of serious side effects. In November 2009, a federal judge presiding over thousands of cases ordered both sides to meet with a mediator to see if there is any possibility for a settlement of Seroquel injury cases before individual trial dates are scheduled in federal district courts throughout the United States.

  • Bret Michaels’ Dad: Rocker Sounds “A Little Slow” But Doing “Fine” After Brain Hemorrhage

    Extra TV caught up with the father of ailing ock idol Bret Michaels outside his Pennsylvania home this week. While Wally Sychak admitted that the ex-Poison frontman is still hospitalized in the ICU of an Arizona hospital after suffering a brain aneurysm on Friday, the older man says his famous son is moving his limbs a little and seems to be on the road to recovery.

    “Well, the fact that he was talking to me, and giving me information, I thought that was great. I understood that this was a terrible ordeal that he was going through. We’re not getting information right now. I guess no news is good news,” said Sychak. “He sounded a little slow, but fine. He was talking, not as cheerful as he usually is. But I guess he is under sedation. But he understood what he was saying and knew me. Everything seemed good that way.”

    Visit msnbc.com for breaking news, world news, and news about the economy


  • US Cellular and Samsung announce the Exec

    Samsung Exec

    Yesterday U.S. Cellular, the nation’s sixth largest wireless provider, announced the addition of the Samsung Exec to their line of Windows Mobile smartphones.  The Exec is geared toward multitaskers who often use their mobile devices for both personal and professional productivity. 

    Here are some of the specs the device offers:

    • Windows Mobile® 6.5 Standard
    • Stereo Bluetooth®
    • 2.0 Megapixel Camera/Camcorder
    • Optional External Memory Up to 32GB
    • CDMA – 1x EVDO
    • Dimensions: 4.61” x 2.36” x .45” inches
    • Weight: 3.7 ounces
    • Display: 2.4” 320 x 240 TFT
    • Talk Time: 8 hours
    • Standby Time: 450 hours
    • User Memory:
      • Program: 79.8MB
      • Data Storage: 123MB
    • Processor speed: 667MHz
    • Autonomous GPS with Bing™

    According to Ed Perez, Vice President of Marketing and Sales for U.S. Cellular, “Many of our customers are multi-taskers who want smartphones that helps them get their work done even when they’re out of the office.  The Exec delivers on this need and most important, keeps them connected with family and friends.”  The Exec is available now for $300 off-contract, or $100 after a two-year agreement and a $70 rebate.  For more information, see the press release below.


    Samsung Mobile and U.S. Cellular® Launch the Samsung Exec™
    April 26, 2010

    Feature-Packed Smartphone Equipped with Windows Mobile 6.5 Platform
    DALLAS – April 26, 2010 – Samsung Telecommunications America (Samsung Mobile)1 the No.1 mobile phone provider in the U.S.2, and U.S. Cellular announce the availability of the Samsung Exec™ (SCH-i225). The Exec is a slim, power-packed smartphone that offers users functionality and a wide array of features.
     
    “Many of our customers are multi-taskers who want smartphones that helps them get their work done even when they’re out of the office,” said Ed Perez, vice-president of marketing and sales for U.S. Cellular. “The Exec delivers on this need and most important, keeps them connected with family and friends.”
    Equipped with a Microsoft Windows Mobile 6.5 platform, Exec users can access personal and corporate email through Microsoft Office Outlook® ActiveSync. The Exec also features other Microsoft Office programs including PowerPoint Mobile and WordMobile to increase mobile productivity at work or home. The Microsoft Windows Mobile 6.5 platform on the Exec allows users to personalize their phone with the Windows Mobile® Device Center, which synchronizes their favorite music, pictures and videos.

    The high-speed HTML browser and spacious full QWERTY keyboard on the Exec offers users a powerful entertainment and social networking feature set, including one-touch access to all the latest Widgets and social networking sites like Facebook™, MySpace™, Twitter and Flicker®. The Samsung Exec also has an array of messaging features including text and picture messaging and access to instant messaging through Windows Live™ Messenger.

    The 2.0 megapixel camera with camcorder enables users to take photos and videos in an instant, while Bluetooth® capabilities offer users seamless hands-free communication. Additionally, the Exec is equipped with a built-in music player and optional external memory up to 32GB. 
    Key features of the Samsung Exec include:

    Windows Mobile® 6.5 Standard
    Microsoft Office Outlook® ActiveSync
    Microsoft Internet Explorer ®
    Microsoft Windows Live™Messenger
    Microsoft Windows Media® Player
    Microsoft Windows Marketplace
    Adobe Reader LE 2.5
    Stereo Bluetooth® Connectivity
    2.0 Megapixel Camera/Camcorder
    Text, Picture and Video Messaging
    Personal Tools: Calendar, Alarms, Anniversary Reminder, Tasks
    Optional External Memory Up to 32GB
    Up To Talk Time: 8 hours
    Dimensions: 4.61” X 2.36” X .45” inches

    The Samsung Exec is available at U.S. Cellular retail locations or atwww.uscellular.com. For additional information about the Samsung Exec visitwww.samsung.com.