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  • Avandia Recall May Be Coming, FDA Considering Halt of Safety Study: Report

    The FDA is considering whether to stop a diabetes drug safety trial due to concerns over the heart risks with Avandia, according to a report in the Wall Street Journal. The decision about whether to halt the trial will likely be linked to the agency’s view on the safety of the drug, and there is speculation that it may be a prelude to an Avandia recall.

    FDA Commissioner Margaret Hamburg sent a letter to U.S. Senator Charles Grassley last week saying that the FDA is considering shutting down a comparative study on the side effects of GlaxoSmithKline’s Avandia and Takeda Pharmaceutical’s Actos diabetes drugs over concerns about the ethics of continuing the trial. If the study is shut down because the FDA deems exposing clinical subjects to potential Avandia health problems is unethical, it is an indicator that the FDA could recall Avandia for the same reasons.

    According to the letter, first reported by the Wall Street Journal, the FDA has not yet made a decision on the clinical trial, called TIDE, which is comparing the two drugs’ heart risks. FDA officials have said that canceling the trials cannot be “de-linked” from the FDA’s view on the safety of Avandia, suggesting that if the trials are halted, the FDA may ask Glaxo to pull Avandia from the market.

    Avandia (rosiglitazone) was approved in the United States in 1998 to treat type 2 diabetes by helping control blood sugar levels. The drug has been used by millions of diabetics, but sales have plummeted in recent years as concerns have mounted about the risk of serious and potentially life-threatening heart risks with Avandia. Some experts estimate that Avandia has caused between 60,000 and 200,000 heart attacks and deaths due to cardiovascular problems in the U.S. from 1999 to 2006.

    recent U.S. Senate report determined GlaxoSmithKline knew that Avandia caused heart problems, but failed to inform the U.S. drug regulators. The Senate report also revealed that some FDA drug safety reviewers have been calling for an Avandia recall since 2007. Senator Grassley is the ranking member of the Senate Finance Committee which issued the report after a two year investigation.

    Concerns about the risk of heart problems with Avandia first gained widespread attention in May 2007, when a meta-analysis of 42 different clinical trials was published in the New England Journal of Medicine, suggesting that users of Avandia had a 43% increased risk of a heart attack.

    In the United States, GlaxoSmithKline PLC currently faces thousands of Avandia lawsuits filed by former users of the drug who allege that the drug company failed to adequately research their medication or warn users about the serious side effects. Federal Avandia litigation has been consolidated into an MDL, or Multidistrict Litigation, for pretrial litigation in the U.S. District Court for the Eastern District of Pennsylvania, where the first trials are expected to begin later this year.

  • Sharon Osbourne Breast Implants Paper Weights!

    Sharon Osbourne is turning her “awful” DD breast implants into paper weights for her husband Ozzy.

    Visit msnbc.com for breaking news, world news, and news about the economy

    “It’s true,” the Celebrity Apprentice star told Ann Curry on NBC’s TODAY Show on Monday morning, confirming an earlier scoop published in Britain’s The Sun last month. “Better on his desk than in my chest,” she cracked.

    Sharon, who currently sports a 34DD chest, will reportedly have a breast reduction in July. She plans to drop down two cup sizes.


  • Betting on change

    by Clive Thompson

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    Last year, Beluga Shipping discovered that there’s money in global warming.

    Beluga is a German firm that specializes in “super heavy lift” transport. Its vessels are equipped with massive cranes, allowing it to load and unload massive objects, like multi-ton propeller blades for wind turbines. It is an enormously expensive business, but last summer, Beluga executives hit upon an interesting way to save money: Shipping freight over a melting Arctic.

    Beluga had received contracts to send materials on a sprawling trip that would begin in Ulsan, South Korea, head north and west to the Russian port city of Archangelsk—located near the border with Finland—and wind up in Nigeria. Normally, this route requires Beluga’s ships to navigatea 11,000-mile route through the Suez Canal. But in 2008, executives for Beluga Shipping decided that global warming had eroded the Arctic’s summer sea ice significantly enough that their ships could travel the Northeast Passage [PDF] along the north coast of Russia. Previously,a cargo ship could only safely navigate that route if an icebreaker went ahead, smashing a route through thick ice.

    Now, a warming climate had—for six to eight weeks beginning in July—transformed much of the route into mostly open water, studded with ice floes that the Beluga ships could navigate. So its executives got permission from the Russian government to travel along the coast, paid a transit fee of “a comparably moderate five-digit figure,” and sent the ships on their way. Four months later, they’d finished the trip. Compared to the old Suez Canal journey, this shorter route saved an enormous pile of money: It cost $300,000 less per ship in lower fuel and bunker costs. Global warming had boosted the company’s revenues by more than half a billion dollars in one year alone.

    When I interviewed Beluga CEO Niels Stolberg via email this spring, he said he envisions using the Northeast Passage regularly. Indeed, he’s planning on another trip this summer. He said that since the shorter passage requires generating far less C02, it’s “greener”; it’s also more ironic, since it was high concentrations of C02 that helped melt the route in the first place.

    “I am convinced,” Stolberg added, “that the Arctic will become an area of quite regular sea traffic at least during summer.”

    If you looked merely at the realm of politics, it would be easy to believe that the question “Is climate change really happening?” is still unresolved. In recent months, skeptics have attacked climate science with renewed vigor. Doubters seized on “Climategate”—leaked emails from bickering atmospheric scientists—to argue that the evidence in favor of warming is being cooked. Other skeptics unearthed shoddy parts of the Intergovernmental Panel on Climate Change’s main report, such as the fact that it cited non-peer-reviewed work by an activist group when it predicted that the Himalayan glaciers would melt by 2035. And all along, conservative politicians have hissingly denounced global warming as a shady liberal scheme: Senator James Inhofe of Oklahoma has famously called it “the greatest hoax ever perpetrated on the American people.” These attacks appear to be working. A spring Gallup study found that Americans’ concern over global warming peaked two years ago, and has steadily declined since.

    But there’s one area where doubt hasn’t grown—and where, indeed, people are more and more certain that climate change is not only real, but imminent: The world of industry and commerce.

    Companies, of course, exist to make money. That’s often what makes them seem so rapacious. But their primal greed also plants them inevitably in the “reality-based community.” If a firm’s bottom line is going to be affected by a changing climate—say, when its supply chains dry up because of drought, or its real estate gets swamped by sea-level rise—then it doesn’t particularly matter whether or not the executives want to believe in climate change. Railing at scientists for massaging tree-ring statistics won’t stop the globe from warming if the globe is actually, you know, warming. The same applies in reverse, as the folks at Beluga Shipping adroitly realized: If there are serious bucks to be made from the changing climate, then the free market is almost certainly going to jump at it.

    This makes capitalism a curiously bracing mechanism for cutting through ideological haze and manufactured doubt. Politicians or pundits can distort or cherry-pick climate science any way they want to try and gain temporary influence with the public. But any serious industrialist who’s facing “climate exposure”—as it’s now called by money managers—cannot afford to engage in that sort of self-delusion. Spend a couple of hours wandering through the websites of various industrial associations—aluminum manufacturers, real-estate agents, wineries, agribusinesses, take your pick—and you’ll find straightforward statements about the grim reality of climate change that wouldn’t seem out of place coming from Greenpeace. Last year Wall Street analysts issued 214 reports assessing the potential risks and opportunities that will come out of a warming world. One by McKinsey & Co. argued that climate change will shake up industries with the same force that mobile phones reshaped communications.

    Consider, as one colorful example, the skiing industry. Beginning ten years ago, the Aspen Skiing Company began noticing that European ski lodges were being slowly destroyed by warmer weather. Europe’s ski resorts tend to be located on lower mountains—about 6,000-8,000 feet high, compared to American peaks up around 11,000 feet—so they’re vulnerable to even extremely tiny increases in global temperature. The 2 percent rise in the 20th century was enough “to put a lot of them out of business,” says Auden Schendler, executive director of sustainability for the Aspen Skiing Company, which operates two resorts spread across four mountains.

    But now Aspen’s own season is getting shorter: “More balmy Novembers, more rainy Marches,” Schendler says. “That’s what we’re seeing, and that’s what the science suggests would happen. If you graph frost-free days, there are more and more in the last 30 years.” Climate-change models also predict warmer nights. Aspen Skiing has noticed that happening too, and the problem here is that nighttime is when ski lodges use their water-spraying technology to make snow—“and if you make it when it’s warmer it’s exponentially more expensive.” The increasing volatility of weather overall—another prediction of climate change—poses a particular danger for ski resorts, because they operate in the red most of the year, making up their deficit during the ultra busy spring break in March. So if the weather is terrific for the entire winter but suddenly balmy during March break, that can ruin the whole fiscal year.

    Schendler has also learned firsthand a point that climate scientists have been making for some time: With climate change, “warming” isn’t the only—or even the most serious—challenge. The sheer interdependence of complex ecosystems systems can grease you. For example, recent droughts in Utah have kicked up red dust clouds that settle on Aspen’s snow. This makes the snow melt more quickly (because the red absorbs more heat from the sun) while also making it too gritty to ski on.

    Are all Aspen Skiing’s recent weather problems caused by global warming? It’s impossible to tell. But as Schendler notes, the last few years certainly mimic the precise effects that climate models predict, so it is at least a taste of what’s to come. During a recent dust storm on Aspen’s slopes, Schendler’s boss wandered into his office looking morose. “He said, ‘Auden, if climate change is the scary thing for the future, this is the apocalypse now. What if you get this in March?’‘’ Schendler recalls.

    Now, all this tricky weather hasn’t exactly destroyed Aspen Skiing; the firm could probably survive even worse stuff. The top of the mountain is so high “we can ski it in 50 years and it’ll be great,” Schendler notes. But it could certainly erode Aspen’s profits, and Colorado would suffer: The ski industry overall is a $2 billion business for the state, employing fully 8 percent of the workforce.So to try and preserve its profit margins, the Aspen Skiing Company has recently become a loud voice in favor of congressional action on the climate. In 2007, Schendler testified before the House Subcommittee on Energy and the Environment, calling for a cap on carbon emissions—among other things.

    “Our attitude when we go to Congress is, look, we’re a business!” he adds. “We didn’t ask for this. We just started looking at the data and the science dispassionately and said, look, we’ve got a problem.”

    Another industry that can’t pretend climate change is a myth is insurance. Insurance firms have always carefully studied real-world data to figure out what, precisely, constitutes a risky activity. As a result, they were among the first to notice that weather was getting more violent, and more unpredictably so.

    “It’s just a logical consequence,” says Peter Hoppe, head of the “Geo Risks Research” division of Munich Re, the multinational reinsurance firm. “Global warming affects our core business. We have seen changes already in some readings.” Worldwide, Munich Re has found that “great catastrophes”—act-of-god weather events that cause more than a billion dollars of damage— have tripled since 1950. In 2008, even though there weren’t any Katrina-level disasters, weather-related events were so severe that “catastrophic losses” to the world’s economy were the third-highest in recorded history, topping $200 billion globally—including $40 billion in the United States. Hoppe doesn’t think global warming is all to blame; some of these events are likely due to natural cycles like the 30-year “North Atlantic Oscillation” that is currently warming the Atlantic. But Munich Re’s policy is that anthropogenic global warming is already making things worse, and that governments ought to act quickly while they still can.

    Granted, a warming globe isn’t just downside for insurance firms. There are also profitable new business opportunities, as Hoppe points out. Munich Re is now offering coverage for renewable energy products, because wind farms and solar parks need insurance against the possibility that low wind and weak sunlight will reduce their output. “It’s very important for investors to dampen and level out the volatility from season to season,” Hoppe says. Munich Re has also developed a product to cover solar cells that wear out before their expected 30-year lifetime.

    Buying insurance against bad weather isn’t entirely new. Farmers have done it for years. But back in the late ‘90s, before Enron imploded, it created a huge new market of selling “weather futures” to electric utilities—hedges that would pay out if, say, a mild summer hurt their sales (because people would use less air conditioning.) After Enron pancaked, weather futures stayed around—still mostly for utilities and farms—but buying them wasn’t easy: You had to personally contact one of the few weather-futures traders who’d set up their own trading desks in the wake of Enron’s dissolution. But with climate-change models predicting increasingly erratic weather, a new generations of startups is heading into the field, figuring that almost any firm might want to hedge against the bad economic effects of weather—such as clothing manufacturers (who could suffer massive losses in coat sales if an unexpectedly mild winter emerges) airlines (since weather is the top cause of delays) or sporting-event promoters (when it’s rainy, everyone stays away).

    Weatherbill is one such startup. Founded three and a half years ago by Google expatriates, it lets anyone use their website to quickly create weather insurance for almost anything. Type in the thing you’re trying to insure—say, an Iowa county fair in the third week of July—and the Weatherbill system calculates the probability of what the local weather will be like up to two years out, down to a 100-mile-wide area. It then uses that guess to instantly price a weather future or insurance contract. CEO Dave Friedberg told me Weatherbill had already sold contracts to the likes of the US Open, and that he envisions worldwide opportunities: Global agriculture suffers billions in weather-related losses each year, for example, yet many countries don’t have any institutions offering easy weather insurance. That’s especially true for countries likely to be the first to experience the dire consequences of climate change, such as coastal regions of Asia or Latin America.

    “If you think about Brazil, their two biggest industries are mining and agriculture,” Friedberg says. “That’s billions of dollars, and there’s a massive market for developing crop insurance. If we can figure out agriculture and do it right, the opportunity is huge to go country by country.” Does he believe that global warming is already noticeable? “Oh yeah,” he says. In just the three years that Weatherbill has been collecting data, extreme weather events have risen 8 percent.

    One of the big political questions of climate change is how far we’ve gone: Have we passed a tipping point of no return? Has the atmosphere already accumulated such high levels of greenhouse gases that even if we manage to cut back on emissions, we’ll still wind up with a globe so much hotter that everyday life will change significantly? One emerging sector built on the assumption that we have is the “adaptation marketplace”— firms offering new products and services to help companies and cities cope with changes. A 2009 study by Oxfam identified seven potentially lucrative adaptation areas, such as water management and disaster preparation; one firm in this field—the Minneapolis-based Pentair Inc., which makes pumps and filtration systems—has soared to $3.35 billion in annual revenues, partly due to contracts from the Army Corps of Engineers to provide massive pumps that will protect New Orleans against another Katrina. Another firm, North Carolina’s WeatherPredict, has developed a technique to retrofit roofs with aerodynamic edges, reducing the damage they sustain in hurricane winds. Firms that produce genetically engineered crops are also predicting they’ll reap profits from climate change: Monsanto, Bayer, BASF, and their sister firms have registered 55 worldwide patents for “climate ready” seeds designed to thrive in conditions of drought or other stress, according to a 2008 report by ETC Group, an environmental advocacy organization.

    Will all this climate-propelled economic activity be good for the planet? Sure, it can be satisfying to see some major CEOs agree that climate change is a real and present danger. But many environmentalists predict that the flurry of new economic activity will create its own new problems.

    The melting Arctic, in particular, gives many observers the willies. It’s likely to see an explosion in seabed oil-and-gas exploration and tourism. (Cargo shipping, interestingly, is likely to increase at a slower rate, partly because cargo ships ferrying “just in time” products can’t abide the delays that even small ice floes would cause—and nobody thinks the Arctic will be entirely ice-free for 100 years or more.) Arctic experts—and the Navy—predict a catastrophe the first time a tourist vessel or oil tanker hits an iceberg and cracks up. “Tourist vessels aren’t ice-hardened, and in the polar regions “there’s no search and rescue or salvage,” standing by says Lawson Brigham, a University of Alaska professor who chaired the Arctic Marine Shipping Assessment, a four-year study of how the commercial activity will progress in the warming north. “The water’s near freezing. All you need is one good Titanic.”

    Other realms of climate-change commerce aren’t much prettier when you look at them closely. In agriculture, the advent of climate-ready crops is clearly useful, maybe even crucial, for adaption. But it also concentrates ever more power in the hands of a small coterie of firms that own the patents to drought-resistant seeds, and the cost could cause serious hardship in the desperately poor countries of Asia or Africa, where the seeds might be most needed.

    And it’s also true that the number of climate visionaries in industry is still quite small. Certainly, companies with skin in the game are preparing for a warmer world. But as the McKinsey report found, they’re in the minority. The grand majority are deeply myopic, focused narrowly on goosing profits in the next quarter—who cares what’ll happen ten years from now? (Read Felix Salmon what makes most businesses so shortsighted here.) In a sense, that makes them mildly agnostic force. When climate change finally does impinge on their business, they’ll probably take action to adapt to it. But it also means that if they can see a short-term profit from fighting against climate science and sowing doubt, they’ll do that, too. This is precisely what’s still happening in the energy industry, where many firms that pay lip service to the reality of climate change also quietly funnel millions to lobbyists who fight ferociously to prevent Congress from passing laws that curtail C02 emissions.

    “We all know big companies who are doing all this green stuff, and their lobbyists are trying to kill the carbon bill as quickly as they can,” says Mindy Lubber, president of Boston-based CERES, an association of environment-minded investors whose members have $10 trillion under management.

    It may be that the corrective force comes not from inside corporations, but from investors. Many large investors, the California State Teachers’ Retirement System—the nation’s second largest public-pension fund—have begun demanding that firms examine and disclose any potential risks from global warming. Shareholder resolutions demanding action on climate change have nearly doubled in the last two years, rising from about 55 in 2007 to 99 in 2009, Lubber notes. In February, the Securities and Exchange Commission issued guidelines requiring that publicly traded firms better disclose their climate-change risk, including potential “physical” risks. (Read a live Grist forum on the new SEC regulations here .)

    “Anyone that’s building out new manufacturing facilities without working out water shortages related to climate change is getting itself into trouble,” Lubber adds. “Or anyone that’s building on waterfront property.” Another common request from shareholder resolutions is for companies to calculate the cost of their carbon footprint. Even if electric utilities and the US Chamber of Commerce are fighting against carbon-limiting legislation, investors seem to believe it is inevitable—indeed, they evidently think the government might cap carbon even in the next few years, which could dramatically increase the cost of electricity.

    To make corporations true partners in tackling climate change, Lubber thinks investors need to push for basic changes in the way their companies function. CEOs whose bonuses are based on bumping next-quarter results will make short-term decisions. Those who are paid based on reducing carbon usage will make long-term ones—investing in technology and processes that reduce greenhouse gases. “If they’re compensated for producing 86 percent more widgets, they’ll do that. But if they use less fuel, they ought to be compensated for meeting their carbon-reduction goals.”

    In the short run, though, there’s probably only one force that will get today’s blithe firms to snap to attention–and that’s legislation. If Congress actually puts a price on carbon, it’ll hit the world of industry with tsunamic force. At minimum, it would probably goose the price of electricity and make emissions-heavy industries instantly less profitable. (Indeed, this is one of the things the SEC and many investor groups are urging firms to do: calculate how badly they’ll be shellacked if new regulations make carbon expensive.) Not everyone will be a loser. The McKinsey study calculated that alternative-energy firms will do quite well (for obvious reasons), but so will less-predictable sectors like the construction industry, as people rush to retrofit buildings with extra insulation and energy-saving rebuilds. The farsighted firms—and the ones who work on the colder fringes of the world—can see the future clearly, because they’re living it. But with the stroke of a pen, Obama can bring it a lot closer. Whether it’s a melting Arctic or a bold new law, the biggest forces shaping industry are, as it were, man-made.

     

    Related Links:

    Corporations love to talk about going green, but not many are planning for a changing climate

    The Climate Desk

    Abercrombie & Fitch + Weight Watchers Make the CRO Black List (VIDEO)






  • POWER POLITICS: TVA chair steps down to focus on conservative fundraising effort

    mike_duncan.jpgAfter serving as chairman of the Tennessee Valley Authority for a year, Mike Duncan stepped down from the post on Friday, citing his new duties leading a new conservative political fundraising organization.

    The former treasurer, general counsel and chair of the Republican National Committee, Duncan is now directing American Crossroads, a new political action committee that’s competing with the RNC to raise money from corporate donors.

    “I recently have taken on some additional responsibilities that I also believe are extremely important,” Duncan said, adding that he thinks American Crossroads “will become an important player in American politics.”

    Duncan also serves as chair and CEO of Inez Deposit Bank in Inez, Ky.

    American Crossroads has gotten commitments of almost $30 million so far, and is seeking to raise more than $50 million to help dozens of Senate and House candidates this fall, the National Journal reports.

    The new PAC — which has been referred to as the “shadow RNC” — comes as official GOP fundraising efforts have taken a blow from revelations that RNC officials spent almost $2,000 at a risque club in West Hollywood.

    Duncan will remain on the TVA board, to which he was appointed by President George W. Bush. His selection as chair of TVA last February was controversial, passing by a vote of 4-3 — a rare show of dissension by TVA board members, who usually act unanimously. Southern Alliance for Clean Energy Executive Director Stephen Smith described the choice of Duncan as “overly partisan and tone deaf.”

    Unanimously picked to replace Duncan as TVA chair was Dennis Bottorff, chair of the Nashville venture capital firm Council Ventures. Though he’s a major contributor to GOP candidates, Bottorff was one of the board members who voted against Duncan’s chairmanship.

    Bottorff notes that the energy industry is changing in profound ways that will require major capital investments and new ways of doing business:

    “The new environmental regulations that are being contemplated in Washington will present enormous challenges to TVA’s engineering and financial teams, along with challenges — as well as opportunities — to its leadership and employees. I hope I am able to help TVA’s senior management team, and my fellow Board members, provide the leadership that we will need to navigate these critical times.”

    But like Duncan, Bottorff has no prior management experience in the electric power industry.

    Bottorff takes TVA’s helm as the utility giant — a federally owned corporation that generates most of its electricity by burning coal — faces a class-action lawsuit from people impacted by the massive December 2008 spill of more than a billion gallons of toxic coal ash from TVA’s Kingston plant in eastern Tennessee. TVA unsuccessfully sought immunity from the suit by arguing that it was an arm of the federal government, even though it is self-financed. It’s estimated that the cleanup is costing the utility more than $1 billion, not including litigation.

    As a result of the Kingston disaster, the Obama administration is currently considering new regulations for coal ash that could also have a big impact on TVA’s business and bottom line.

  • Seat Alhambra 2010

    La marca española acaba de presentar la nueva versión del actual Seat Alhambra que está basado en la plataforma del Volkswagen Sharan. El nuevo Alhmabra ha aumentado tanto sus dimensiones de largo como de ancho lo cuál le permite tener un interior aun más espacioso y cómodo para sus ocupantes.

    Una de las nuevas características más importantes es sin duda las nuevas puertas traseras correderas, siendo la primera vez que se usan en este modelo. Exteriormente no se diferencia demasiado del Sharan aunque el modelo español tiene un aspecto más deportivo.

    En su interior pueden viajar hasta 7 adultos y si plegamos los asientos con el sistema “Easy-Fold” tendremos un maletero con una carga total de 2.297 litros. En lo que respecta a la motorización, el motor más destacado es el 2.0 TDI de 140 CV con sistema Start/Stop y la función de recuperación de energía de Seat. En Septiembre llegará a los concesionarios a un precio por determinar.

    Related posts:

    1. Seat Ibiza ST, pre-venta disponible
    2. Seat deja de fabricar el Toledo
    3. Seat Ibiza ST en el Salón de Ginebra
  • BREAKING: Toyota will pay $16.4M fine, denies wrongdoing

    Filed under: , , , ,

    Just yesterday, we told you that Toyota was reportedly set to pay the full $16.4 million fine to the U.S. government, so long as the automaker would not be required to admit any wrongdoing. Well, the ‘T’s have been crossed, the ‘I’s have been dotted, and the official statements have been released. The largest civil fine ever issued to an automaker by the U.S. government will be paid by way of electronic funds transfer, and will take place within the next 30 days. For what it’s worth, The Detroit News reports that if the $16.4 million maximum cap on fines didn’t exist, it could have charged $6,000 per vehicle – that’s $13.8 billion. Ouch.

    As part of that process, Toyota now openly admits that it could have (and should have) done a better job of sharing relevant information, and it welcomes “a new, more transparent chapter” in its relationship with the National Highway Traffic Safety Administration. Additionally, the automaker has outlined a few of its next steps, citing that a new Chief Quality Officer has been appointed for North America and that it has strengthened its information-gathering capabilities in an effort to investigate potential problems with quicker response times. Still, Toyota denies that it withheld any pertinent information from NHTSA, saying, “We did not try to hide a defect to avoid dealing with a safety problem.”

    In response, U.S. Transportation Secretary Ray LaHood has issued the following statement regarding Toyota’s decision:

    By failing to report known safety problems as it is required to do under the law, Toyota put consumers at risk. I am pleased that Toyota has accepted responsibility for violating its legal obligations to report any defects promptly. We are continuing to investigate whether the company has lived up to all its disclosure obligations.

    The U.S. House of Representatives oversight panel plans to hold another hearing on May 6 to further investigate Toyota’s conduct. What’s more, remember that Toyota could be in more hot water regarding the ongoing investigation regarding the Lexus GX460 SUV, and there are still lingering questions about possible electronic gremlins in Toyota throttles to contend with. Still, it’s good to see that an initial resolution has been reached between Toyota and NHTSA on this matter, though it is still possible that further fines will follow. Hit the jump to read the automaker’s official release, as well as a statement from the U.S. Department of Transportation.

    [Sources: Toyota, NHTSA, The Detroit News | Image: Ramin Talaie/Getty]

    Continue reading BREAKING: Toyota will pay $16.4M fine, denies wrongdoing

    BREAKING: Toyota will pay $16.4M fine, denies wrongdoing originally appeared on Autoblog on Mon, 19 Apr 2010 10:33:00 EST. Please see our terms for use of feeds.

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  • 80 Percent of Americans Don’t Trust the Government. Here’s Why

    Public trust of government is near its all-time low according to the Pew Research Center, which finds a perfect storm of factors — including a deep recession, high unemployment and polarized Congress — are driving distrust near an all-time high of 80%. 

    What accounts for this outpouring of discontent? After all, the recession is over, the economy is growing, and job losses have slowed dramatically in the last year. But overall distrust has been permanently scared since the early 1970s, and periods of recession and high unemployment depress public trust in government. Here are three key lessons from the Pew poll:

    1) Blame Nixon, and stagflation
    The United States government suffers from not seasonal, but structural disapproval. This poll isn’t an outlying data point. It’s part of an overall decline in government trust since the mid-1960s. The only time since 1975 that government trust broke 50% was in the months following 9/11. After the tumultuous assassinations of the 1960s, the Vietnam War, the resignation of President Nixon, and the stagflation of the late 1970s, public trust fell from 80% in 1966 to about 25% in 1981. Since then it’s only peaked over 50% once, after 9/11. Nixon’s scandal, the regularity of hyperpartisanship, the rise of cable news, and the annual parade of government frustrations that belie the quixotic campaign promises Americans now expect from outside candidates has permanently eroded faith in the US government.

    2) Blame the recession
    This graph tells a simple story: even as counter-cyclical spending tends to increase government support of Americans during recessions, Americans’ faith in government consistently falls in downtimes. Note the spikes in distrust during the recessions of the mid-1970s, early 1980s, early 1990s and late 2000s. The only recession that did not cause a spike in distrust was the early 2000s, but the era of unity and patriotism that followed 9/11 accounts for that rare burst of trust in government.
    trust distrust.png
    3) Blame partisanship
    Politics is allegedly zero-sum, but eroding trust has hurt both parties. The lesson in the graph below is that while rising public distrust generally spells trouble for incumbents (bad news for Democrats), the current falloff has actually been much more dramatic for the Republican Party, which is experiencing the lowest public trust levels of any party in the last 50 years.
    trust republicans dems.pngWhat does this survey mean for the future? A poll is just a poll, but there is evidence that economic downturns and collapsing distrust in government leave lasting scars on the body politic. In their NBER working paper Growing up in a Recession, co-authors Paola Giuliano and Antonio Spilimbergo found that individuals going through a recession trust Congress less, but rely on it more. It is difficult to determine whether recessions set the stage for rising Democratic or Republican tendencies: “on the one hand, recession-hit individuals believe that the government
    should intervene more, so they lean more to the left. On the other
    hand, these individuals distrust institutions, believing them to be
    ineffective, therefore leaning more to the right.”

    If this sounds schizophrenic, it’s hardly different from the schizophrenia Americans already suffer when we blast the government for deficit spending even as we largely defend entitlements (40% of the budget), defense spending (20%), relief for the unemployed, and the historically low tax rates that make the deficit the deficit. What does it mean that we’ve become a country that expects a government we don’t trust to provide growing benefits from taxes we don’t want to pay?





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  • Ikea Kitchen Squad ready to shock and awe

    If you know people with a dingy kitchen you may want to let loose the Ikea kitchen squad on them. Ikea Kitchen Squad is a TV show in the UK featuring an undercover group of designers, planners, service experts and installers who fly in to save the day for teary and weary homeowners.

    Previously they have already helped three kitchens in crisis, by creating cool Ikea kitchens tailored to their needs and family requirements. Now they want to do the same for Colleen whose dingy kitchen with doors hanging off and an overheating oven is just too small for the family to sit around in together and enjoy an evening meal. 

    Colleen’s kitchen Ikea-Kitchen-Squadified

    The one they killed

    I’m not sure when it’ll air and I won’t be able to catch it (it being on UK TV and all). But if you do, let me know how it when. Check out the trailer.

    Click for more info on Ikea Kitchen Squad.


  • U.S. Navy Targets Microbe that Feasts on Mud for New Fuel Cell

    The U.S. Navy is developing a microbial fuel cell that generates electricity from the nutrients in mud and wastewater“Think of it as a battery that runs on mud,” says the U.S. Office of Naval Research, and there in a nutshell is the concept behind the Navy’s new microbial fuel cell. The Navy has been using small lightweight microbial fuel cells to power sensors (to track sea turtles, for example) and now its goal is to develop one that is powerful enough to steer a small robotic watercraft.

    In a microbial fuel cell, organisms feed on available nutrients and generate an electric current as they metabolize the food. The Navy is working with researchers at the University of Massachusetts on a microbe called Geobacter, which is the most promising in terms of its efficiency at generating electricity. Strains found in the wild have demonstrated a knack for converting nutrients in mud and wastewater into electrical current, and researchers have developed a new strain that is eight times more efficient than others.

    (more…)

  • Quick App: Paintr Lite

       

    Creative types of applications in the App Catalog have tended towards the anemic side of functionality and usefulness, but as time progresses, that trend is beginning to change. We took a quick look at Paintbox ($0.99 in the App Catalog) not too long ago, and if you were excited about the prospects of that app and what it had to offer, you’re in for a real treat here.

    Paintr Lite (Free in the App Catalog) offers a 16 color paint pallet, 3 types of brushes (hard, soft, and dry) with selectable brush size, opacity, speed sensitivity, with the brush textures created being very lifelike.  The color options are nearly limitless, as the user selectable opacity allows for the mixing of hues to create colors that aren’t available in the color picker.  Like many of application’s contemporaries in the Catalog, there’s no way to export your canvas other than taking a screenshot of your work (option key + symbol + P). 

    The program, as basic as it may seem, has allowed people to create some rather striking images considering that they were done on a 3.1” touchscreen using  an app that utilizes nothing more than web technologies . To show off what the app is capable of, there’s an integrated gallery (where the above screenshot of the Marylin "painting" came from) allowing users to showcase their work.

    The developer is said to be working on a “Paintr Pro”, but the webOS development framework currently lacks the features needed make to make a paid version worthwhile to the end user. That will all change, hopefully, when the masses can release PDK enabled apps into the Catalog. 

  • iPad Accessories Series: Portable Bluetooth Keyboard Roundup

    My recent account of mobile blogging on the iPad with a portable keyboard touched a vein, and I have been flooded with requests for information about other keyboards that will work with the iPad. I have used portable keyboards with UMPCs and other devices for a long time and they can definitely turn a mobile device into a full workstation. These questions sent me on a quest for keyboard options for use with the iPad, since the older Stowaway model I am using is no longer available. I didn’t think I would find many options, but found a few that might interest those looking for one to use with the iPad.

    Apple Wireless Keyboard. Apple is touting its wireless keyboard for use with the iPad, and reports are it works well. It is fairly small and fits in most gear bags, but it is not the smallest option on this list. $69.

    Apple iPad Keyboard Dock. This is a dock and keyboard all in one, and is designed for the iPad. It is a bit bulky to carry while mobile, but some are doing that and loving it. $69.

    iGo Ultra-Slim Bluetooth Keyboard. This keyboard is no longer made by iGo, but is still available in quantities online. The iGo keyboard folds up to a pocketable size, yet opens to a full-sized keyboard that works with PDAs, smartphones and PCs. The small size is due to the lack of a number key row, which some will not like. It works well with the iPad. Around $150.

    Freedom Portable Keyboard. The Freedom is a Bluetooth keyboard that folds in half for transport in a small form. $80.

    Palm Wireless Keyboard. Palm made a keyboard for use with the Treo, and it is still sold online. The Palm keyboard is a portable keyboard that works with Windows PCs, so it should work with the iPad. $66.

    Fentek Portable Keyboard. Not much is known about this keyboard but there are both Windows and Mac key layouts available. It’s not the smallest keyboard but it folds in half for transport. $95.

    These are by no means the only portable keyboards available, but the list is a good place to get started when looking for a wireless keyboard. These keyboards should work with any computer as well as the iPad, but there are no guarantees.

    Don’t miss the other installments in the iPad Accessories Series:

    Related content on GigaOM Pro (subscription required):

    Hot Topic: Apple’s iPad

  • NanoString Unveils MicroRNA Kit

    Luke Timmerman wrote:

    NanoString Technologies, the Seattle-based maker of tools for genetic analysis, said today it has introduced a new product to analyze microRNA molecules on its nCounter instrument. MicroRNAs are tiny strings of RNA that don’t make genes, but are thought to regulate the activity of important biological processes. NanoString is rolling out the new application to coincide with the annual meeting of the American Association for Cancer Research in Washington D.C., where a number of enthused microRNA researchers are gathered today. NanoString primarily sells its instrument to researchers who want to look at how genes are dialled on or off in a sample, and it also foresees using the technology as a diagnostic tool.

    UNDERWRITERS AND PARTNERS



























  • Neil Patrick Harris To Narrate PBS Documentary “Through A Dog’s Eyes”

    Emmy-nominated star/pooch lover Neil Patrick Harris takes a look at the incredible world of service dogs as the narrator of the new PBS documentary Through a Dog’s Eyes.

    Neil dropped by The Early Show Monday to talk about the special, which airs on PBS April 21. Check your local listings for showtimes….


  • Next Generation Smart Cars Will Get Diesel, Hybrid, Electric Versions

    I’m not a huge fan of Daimler’s ‘other’ brand. Smart cars just look so… small and awkward. But, before you hate on me, I do realize that they are relatively affordable, sip fuel, and remarkably safe for their size. Just… they’re not for me. Seems a boatload of other people agree as Smart sales have been plunging off a cliff lately for who-knows-what reason.

    Daimler, who owns Smart, has big plans for the small brand of cars though, and those plans include a strategic alliance with Renault-Nissan. Apparently they’ll be resurrecting the four-person ForFour model (they really need better names) and adding diesel, hybrid, and fully electric drive systems to their vehicles. Smart 2.0 sounds like it might have a chance.

    (more…)

  • Cases of E. Coli Food Poisoning Declined in 2009: CDC

    The number of illnesses from E. coli food poisoning dropped 12% in 2009, dipping to a five year low according to newly released federal statistics. 

    The U.S. Centers for Disease, Control and Prevention (CDC) announced the decline in cases of E. coli on Thursday in a new report on 2009 food poisoning rates. The CDC said the drop brought E. coli poisoning incidents to their lowest numbers since 2004.

    The CDC looked at nine different foodborne pathogens in the United States. While most remained flat, sickness from eating foods contaminated with E. coli O157:H7 dropped 12%. There was also a major drop in the number of illnesses caused by shigella bacteria, which is harder to track because it is believed that only about 20% of shigella illnesses are caused by contaminated food.

    Federal health officials tracked food poisoning cases through data from 10 states collected by the Foodborne Diseases Active Surveillance Network, or Foodnet. The network has found that E. coli O157:H7 and Shigella illnesses have declined 41% and 55%, respectively, since it first started tracking foodborne illnesses in 1996. Salmonella food poisoning has only had a moderate decline of about 10% over the same time period.

    CDC officials say that the decrease in E. coli illnesses is most likely due to improved safety measures in the meat and produce industries. E. coli O157:H7 is of particular concern because up to 10% of food poisoning from that particular strain of E. coli results in kidney failure.

    E. coli O157:H7 is one of the more common causes of food poisoning in the United States. When left untreated, it can lead to dehydration and potentially life-threatening illness. While most healthy adults recover within a few week from E. coli food poisoning, young children and the elderly could be at risk for more severe illness. If the toxin enters the blood stream, E. coli could also lead to kidney failure known as Hemolytic-Uremic Syndrome (HUS).

    The CDC reports that there are about 76 million cases of food-related illnesses reported every year, with more than 300,000 people hospitalized and 5,000 deaths. There were at least nine major recalls of beef products in 2009.

  • Oil & Gas in Algeria: $100M deal as LNG summit starts

    The biggest players in the oil and gas industries are assembling in Oran, Algeria today for the 3-day LNG 16 conference, which brings together more than 2,500 attendees for the largest event in the world dedicated to the liquefied natural gas industry. As a global leader in LNG technology, GE Oil & Gas — which has been operating in Algeria for over 45 years — not only has a big presence at the summit, but it has just announced new deals in the country. In a $100 million contract with Petrofac, which provides services to many of the world’s largest oil & gas companies, GE is providing turbo compression equipment for the use in the El Merk Project, which is located in a harsh, remote section of the Sahara. It comes as GE’s new $36M investment in Algeria to expand the ALGESCO Service Center — which will be the largest GE Oil & Gas Service Center in the world — is nearing completion and will be formally inaugurated later this year.

    GE Oil & Gas, with $7.7 billion in revenue in 2009, has more than 12,000 employees in 100 countries.
    Thinking big: GE Oil & Gas, with $7.7 billion in revenue in 2009, has more than 12,000 employees in 100 countries. Algeria, which is the third largest supplier of gas to Europe, has one of GE’s largest installed equipment bases including more than 400 gas turbines, more than 340 compressors and 35,000 km of inspected pipelines.

    In LNG production, gas is liquefied to make it easier to transport via ship or pipeline. As The Center for LNG describes it: “Natural gas is converted to LNG by cooling it to -260° F, at which point it becomes a liquid. This process reduces its volume by a factor of more than 600 — similar to reducing the volume of a beach ball to the volume of a ping-pong ball.”

    GE supplies technologies used up and down the full LNG chain, including the critical series of compressors known as “compression trains” that are required for virtually all of the major LNG processes. For example, in the massive Gorgon project off the coast of Australia, GE’s “Refrigerant Compression Trains” will be chilling the natural gas to a liquid state. That technology is also driving the QatarGas 2 project, which now boasts the largest LNG plant in the world, featuring four trains. And at the heart of those LNG trains are twelve of the largest refrigeration compressor systems manufactured by GE.

    Liquefied natural gas is loaded onto ships and eventually offloaded and turned back into a gas.
    Tech talk: Liquefied natural gas is loaded onto ships and eventually offloaded and turned back into a gas. In addition to presenting technical papers at the summit, the Oil & Gas team is participating in a panel with Shell and ExxonMobil on “Technical Innovations for the Future of the LNG business.” Some of GE’s latest innovations are being put through their paces in Massa, Italy, where GE Oil & Gas recently invested over $9 million in a new test bed in preparation for the oncoming increase in liquefied natural gas activity. The new facility is designed for thermodynamic and mechanical tests on large compressors.

    In addition to the Algeria news, GE Oil & Gas last week announced a joint venture in India to design, manufacture, supply, sell and service advanced technology steam turbines. It also announced a new memorandum of understanding with Vietnam that will be the basis for a long-term collaboration on the supply of advanced oil and gas equipment, services and spare parts.

    The M.O.U. with Vietnam was signed by Nguyen Quoc Thap, vice president of Petrovietnam and Marco Caccavale, general manager of GE Oil & Gas in North America.
    Filling the pipeline: The M.O.U. with Vietnam was signed by Nguyen Quoc Thap, vice president of Petrovietnam and Marco Caccavale, general manager of GE Oil & Gas in North America. Vietnamese Prime Minister Nguyen Tan Dung, center, attended the ceremony in Washington D.C.

    * Read today’s Algeria announcement
    * Read the announcement about GE’s joint venture in India
    * Read the announcement about GE’s new agreement in Vietnam
    * Read “A monster of a deal gets bigger: Gorgon passes $1.1B” on GE Reports
    * See more GE Oil & Gas stories on GE Reports
    * Read about GE’s new turbine becoming an ecomagination-certified product
    * Learn more about LNG technology
    * Learn more about our LNG test facility

  • Corporations love to talk about going green, but not many are planning for a changing climate

    by Felix Salmon

    .series-head{background:url(http://www.grist.org/i/assets/climate_desk/header.gif) no-repeat; height:68px; text-indent:-9999px;} h3.subscribe-head{padding-left:5px;background-color:black;color:#ff8400;} dl.series-nav{margin-top:-15px;}

    About a decade ago, Miguel Torres planted 104
    hectares of pinot noir grapes in the Spanish Pyrenees, 3,300 feet above sea
    level. It’s cold up there and not much good for grapes—at least not these
    days. But Torres, the head of one of Spain’s foremost wine families, knows that the climate is changing.

    His company’s scientists reckon that the Rioja wine
    region could be unviable within 40 to 70 years, as temperatures increase and
    Europe’s wine belt moves north by up to 25 miles per decade. Other winemakers
    are talking about growing grapes as far north as Scandinavia and southern
    England.

    Torres’ Pyrenees vineyards are a hedge and may
    not be necessary. But if climate change redraws the map of Europe’s wine world,
    he will be prepared. And his company will be one of a very few taking steps to
    adapt to the future effects of climate change.

    How companies are preparing for these changes is a
    pressing topic, but when I agreed to write this piece I knew I was no expert. I
    set out to educate myself by posting open requests on my finance blog at
    Reuters
    , asking my eager-to-comment audience of business wonks to
    tell me stories of how big corporations are getting ready.

    The idea was that my readers and other bloggers
    would cheerfully provide me with examples of how companies are preparing for
    the downsides—not to mention the opportunities—of climate change. I braced
    myself for the inevitable barrage of responses; what I got was a shocking lack
    of evidence that the corporate sector is doing much of anything.

    Most companies seem to focus solely on mitigating
    changes to the climate: reducing carbon emissions, improving environmental
    sustainability, and striving to be an enlightened steward of the planet.
    Adaptation is the opposite, more pessimistic approach: It is about ensuring
    survival in the exceedingly likely event that climate change occurs.

    The U.S. government is trying to create
    incentives for businesses and their investors to plan ahead. Newly issued SEC regulations mandate that any material risk
    connected to climate change has to be revealed, in an attempt to bring these
    issues out into the open and to allow investors to compare the ways that
    companies see climate risks and adapt their strategies accordingly.

    There are, to be sure, a few examples of
    corporations that are treating climate change as an ominous reality, or even as
    an opportunity. The biggest funders of Brazilian agricultural projects, state-owned
    banks BNDES and Banco do Brasil, are looking carefully at whether it makes
    sense to support projects which might not be viable in 20 or 30 years’ time. Agribusiness
    giants like Cargill and Monsanto are developing hardier crops, global shipping firms
    are planning for an ice-free Arctic passage [Clive link TK], and power company TransAlta
    has scrapped potential new plants in the American West because it couldn’t
    ensure that water rights would be available for the next 40 years.

    But those are at the margins. In the mainstream
    business world, climate change adaptation strategies are scant. The reasons for
    inaction are sometimes simple, but also counter-intuitively complex.

    Start with the superficial: Adaptation strategies
    have essentially zero PR value. They
    have nothing to do with saving the planet. Instead, they’re all about trying to
    thrive if and when the planet starts to fall apart. That’s not something any
    savvy company wants to trumpet to the world.

    Then there is the mismatch of time horizons. Climate change takes place over decades,
    and corporate timescales generally max out in the five to seven year range. Businesses
    typically won’t spend significant money planning beyond that period, especially
    because the effects on business models and future profitability are so
    difficult to predict.

    It’s easy to talk about how hotel companies with
    coastal property might have to face more hurricanes, or rising sea levels. But
    it’s quite hard to know what is going to happen to any given beachfront resort with
    a sufficiently high degree of certainty.
    Given the enormous amount of variability in any complex model, if a company
    spent a lot of money carefully mitigating the risk of X, it could end up
    getting blindsided by Y instead.

    “There are very difficult models to develop,
    with more rain here, less rain there,” says Andy Hoffman, associate director of
    the Erb Institute for Global Sustainable Enterprise at the University of
    Michigan.

    Finally, even if the effects of climate change
    are foreseeable, they can be impossible
    to hedge
    .

    Say you’re an electronics manufacturer who is
    pretty sure that climate change is going to wallop Bolivia, resulting in political
    unrest and a spike in the price of lithium. All your devices run on lithium
    batteries, so this is a serious risk, but it’s far from obvious what you can do
    about it. It’s silly to start stockpiling lithium, and you can’t even bet on
    rising lithium prices 10 years from now, since it’s not a metal that is heavily
    traded in the futures markets. Essentially all that you can do is be very clear
    about the risk in your SEC filings, and go about your business as normal. And identifying
    a risk is not the same thing as being able to negate it.

    A classic business hedging strategy is to buy
    insurance. Reinsurance companies have expensive and sophisticated
    climate-change models. Pricing such risk is what they do. In many cases, they
    will make more money as the effects of climate change become increasingly
    visible and expensive, since they’ll simply raise premiums on everybody while
    refusing to insure the most vulnerable at any price.

    But insurance
    doesn’t work very well as an adaptation strategy
    . Policies only last for
    one year, or at most two. The insurance companies don’t need to charge higher
    rates now if they see big and nasty things happening to the global climate in
    20 years’ time—they can continue more or less as they are for the time
    being. It’s easy to forget that if you’re simply renewing an insurance policy
    every year: the existence of the insurance market gives companies a sense of
    false security that their risks are hedged.

    To put it another way, insurance is a highly
    imperfect hedge for climate change, because it can go away or rise in cost very
    suddenly. After the Bhopal disaster in 1984, pollution liability insurance
    first disappeared entirely, and then, when it came back, cost ten times as
    much. The risk of rising insurance costs—or insurance becoming impossible to
    buy at any price—is something so inherently difficult to protect against, most
    companies don’t even bother trying.

    The behavioral economist Dan Ariely, author of “Predictably
    Irrational,” likes to say that climate change is a problem that is perfectly designed to make people do
    nothing
    : It happens far in the future; its effects will be felt most
    greatly by other people; and the efforts of any one individual are minuscule.

    Companies too tend to behave in predictably
    irrational ways. Executives should try to imagine their companies 30 years down
    the line, struggling with the deleterious effects of climate change on
    profitability and corporate survival. But they don’t. That’s a job for the next
    CEO’s successor’s successor. Right now there are a million other things that seem
    much more urgent, starting with this quarter’s earnings.

    Related Links:

    Betting on change

    Will an SEC ruling convert short-term greed into long-term sustainability?

    Dems more trusted on energy than any other issue, continue pursuing polluter-friendly GOP ideas






  • Morgan Stanley: ‘Bridge Painting’ Stimulus Is Over, Now Come The Real Industrial Projects

    Most U.S. stimulus spending hasn’t even hit the economy yet, as shown in the Morgan Stanley Chart below. Only about 40% has been paid out, and about 30% hasn’t even been allocated yet.

    Moreover, the stimulus spending that we’re still waiting for is more geared towards U.S. industrials, and thus we believe is the kind that could deliver more bang for the buck when it comes to stimulating U.S. capital equipment spending and manufacturing activity. The peak effect of stimulus spending hasn’t even happened yet.

    Chart

    (Via Morgan Stanley, Industrials, Scott Davis & Robert Wertheimer, 19 April 2010)

    Join the conversation about this story »

  • Blog Post:The Debate about Liquid Cooled Data Centers

    I’ve been remiss in not posting for a couple of weeks, so I’m trying to get back in the saddle. I’ve been working on other things that have taken up a fair bit of time. One is a web seminar on heatsinks – Heatsink 201 – Even More about Heat Sinks which follows on from Alexandra Francois-Saint-Cyr’s very successful Heat Sink 101 web seminar.

    Back in March I posted about IBM’s work on liquid cooling to take Moore’s Law to 2025. As a side note I observed that, one of the main benefits of liquid cooling in a data center is that the high grade waste heat generated can be used for heating purposes. This changes both the economics of deploying a liquid cooling solution and the environmental impact. The reason this is so important is that data centers are one of the fastest growing consumers of energy.

    (more…)

  • San Diego’s Top 10 Venture Deals: Most of the Money Goes to Life Sciences

    Money Tree
    Bruce V. Bigelow wrote:

    The folks who count every leaf that falls off the money tree for venture-backed startups have graciously provided a breakout of the 10 biggest VC deals in San Diego so far this year. This list was drawn primarily from the MoneyTree Report, which is prepared by the National Venture Capital Association, PricewaterhouseCoopers, and Thomson Reuters. We’ve supplemented the list with information from the archives of Xconomy San Diego—since we wrote stories about all of these deals—as well as regional data provided by Dow Jones VentureSource.

    While the MoneyTree survey counted $222 million invested in 29 deals in the San Diego area, it’s still a relatively small sum for this region. I’ve got more on that, but first, here’s our list of the top 10 deals from the first quarter:

    1. Tandem Diabetes Care (San Diego), $31 million, second tranche of Series C.

    2. PatientSafe Solutions (San Diego) $30 million, undisclosed round.

    3. Tioga Pharmaceuticals (San Diego) $18 million, undisclosed round.

    4. Sotera Wireless (San Diego) $17.45 million, undisclosed round.

    5. Genomatica (San Diego) $15 million, Series C.

    6. Elevation Pharmaceuticals (San Diego) $14.96 million, Series A.

    7. EMN8 (San Diego) $14.46 million, undisclosed round.

    8. VentiRx Pharmaceuticals (San Diego and Seattle) $12.5 million, extended Series A.

    9. Avaak (San Diego) $10 million, Series B.

    10. AwarePoint (San Diego) $10 million, Series E.

    The top 10 deals on the list account for $173.35 million, or roughly 78 percent, of the $222.5 million that venture investors sunk into 29 deals in the San Diego area during the first quarter of 2010, according to …Next Page »