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  • Building the U.S. Battery Industry for Electric Drive Vehicles: Summary of a Symposium

    Cover imageSince 1991, the National Research Council, under the auspices of the Board on Science, Technology, and Economic Policy, has undertaken a program of activities to improve policymakers’ understandings of the interconnections of science, technology, and economic policy and their importance for the American economy and its international competitive position. The Board’s activities have corresponded with increased policy recognition of the importance of knowledge and technology to economic growth. The goal of the this symposium was to conduct two public symposia to review and analyze the potential contributions of public-private partnerships and identify other relevant issues for the Department of Energy, Office of Vehicle Technologies, Energy Storage Team’s activities in the energy storage research and development area. The symposia will also identify lessons from these and other domestic and international experiences to help inform DoE as to whether its activities are complete and appropriately focused. Additional topics that emerge in the course of the planning may also be addressed. Building the U.S. Battery Industry for Electric Drive Vehicles: Summary of a Symposium gathers representatives from leading battery manufacturers, automotive firms, university researchers, academic and industry analysts, congressional staff, and federal agency representatives. An individually-authored summary of each symposium will be issued.

    The symposium was held in Michigan in order to provide direct access to the policymakers and industrial participants drawn from the concentration of battery manufacturers and automotive firms in the region. The symposium reviewed the current state, needs, and challenges of the U.S. advanced battery manufacturing industry; challenges and opportunities in battery R&D, commercialization, and deployment; collaborations between the automotive industry and battery industry; workforce issues, and supply chain development. It also focused on the impact of DoE’s investments and the role of state and federal programs in support of this growing industry. This task of this report is to summarize the presentations and discussions that took place at this symposium. Needless to say, the battery industry has evolved very substantially since the conference was held, and indeed some of the caveats raised by the speakers with regard to overall demand for batteries and the prospects of multiple producers now seem prescient. At the same time, it is important to understand that it is unrealistic to expect that all recipients of local, state, or federal support in a complex and rapidly evolving industry will necessarily succeed. A number of the firms discussed here have been absorbed by competitors, others have gone out of business, and others continue to progress.

  • Emerging Consensus Shows Climate Change Already Having Major Effects on Ecosystems and Species

    Plant and animal species are shifting their geographic ranges and the timing of their life events – such as flowering, laying eggs or migrating – at faster rates than researchers documented just a few years ago, according to a technical report on biodiversity and ecosystems used as scientific input for the 2013 Third National Climate Assessment.

    The report, Impacts of Climate Change on Biodiversity, Ecosystems, and Ecosystem Services, synthesizes the scientific understanding of the way climate change is affecting ecosystems, ecosystem services and the diversity of species, as well as what strategies might be used by natural resource practitioners to decrease current and future risks. More than 60 federal, academic and other scientists, including the lead authors from the U.S. Geological Survey, the National Wildlife Federation and Arizona State University in Tempe, authored the assessment.

    “These geographic range and timing changes are causing cascading effects that extend through ecosystems, bringing together species that haven’t previously interacted and creating mismatches between animals and their food sources,” said Nancy Grimm, a scientist at ASU and a lead author of the report.

    Grimm explained that such mismatches in the availability and timing of natural resources can influence species’ survival; for example, if insects emerge well before the arrival of migrating birds that rely on them for food, it can adversely affect bird populations. Earlier thaw and shorter winters can extend growing seasons for insect pests such as bark beetles, having devastating consequences for the way ecosystems are structured and function. This can substantially alter the benefits people derive from ecosystems, such as clean water, wood products and food.

    “The impact of climate change on ecosystems has important implications for people and communities,” said Amanda Staudt, a NWF climate scientist and a lead author on the report. “Shifting climate conditions are affecting valuable ecosystem services, such as the role that coastal habitats play in dampening storm surge or the ability of our forests to provide timber and help filter our drinking water.”

    Another key finding is the mounting evidence that population declines and increased extinction risks for some plant and animal species can be directly attributed to climate change. The most vulnerable species are those already degraded by other human-caused stressors such as pollution or exploitation, unable to shift their geographic range or timing of key life events, or that have narrow environmental or ecological tolerance. For example, species that must live at high altitudes or live in cold water with a narrow temperature range, such as salmon, face an even greater risk due to climate change.

    “The report clearly indicates that as climate change continues to impact ecological systems, a net loss of global species’ diversity, as well as major shifts in the provision of ecosystem services, are quite likely,” said Michelle Staudinger, a lead author of the report and a USGS and University of Missouri scientist.

    For example, she added, climate change is already causing shifts in the abundance and geographic range of economically important marine fish. “These changes will almost certainly continue, resulting in some local fisheries declining or disappearing while others may grow and become more valuable if fishing communities can find socially and economically viable ways to adapt to these changes.”

    Natural resource managers are already contending with what climate change means for the way they approach conservation. For example, the report stated, land managers are now more focused on the connectivity of protected habitats, which can improve a species’ ability to shift its geographic range to follow optimal conditions for survival.

    “The conservation community is grappling with how we manage our natural resources in the face of climate change, so that we can help our ecosystems to continue meeting the needs of both people and wildlife,” said Bruce Stein, a lead author of the report and director of climate adaptation at the National Wildlife Federation.

    Other key findings of the report include:

    • Changes in precipitation and extreme weather events can overwhelm the ability of natural systems to reduce or prevent harm to people from these events. For example, more frequent heavy rainfall events increase the movement of nutrients and pollutants to downstream ecosystems, likely resulting not only in ecosystem change, but also in adverse changes in the quality of drinking water and a greater risk of waterborne-disease outbreaks.  
    • Changes in winter have big and surprising effects on ecosystems and their services. Changes in soil freezing, snow cover and air temperature affect the ability of ecosystems to store carbon, which, in turn, influences agricultural and forest production. Seasonally snow-covered regions are especially susceptible to climate change because small precipitation or temperature shifts can cause large ecosystem changes. Longer growing seasons and warmer winters are already increasing the likelihood of pest outbreaks, leading to tree mortality and more intense, extensive fires. Decreased or unreliable snowfall for winter sports and recreation will likely cause high future economic losses.
    • The ecosystem services provided by coastal habitats are especially vulnerable to sea-level rise and more severe storms. The Atlantic and Gulf of Mexico coasts are most vulnerable to the loss of coastal protection services provided by wetlands and coral reefs. Along the Pacific coast, long-term dune erosion caused by increasing wave heights is projected to cause problems for communities and for recreational beach activities. However, other kinds of recreation will probably improve due to better weather, with the net effect being that visitors and tourism dollars will shift away from some communities in favor of others.  
    • Climate change adaptation strategies are vital for the conservation of diverse species and effective natural resource policy and management. As more adaptive management approaches are developed, resource managers can enhance the country’s ability to respond to the impacts of climate change through forward-looking and climate science-informed goals and actions.
    • Ecological monitoring needs to be improved and better coordinated among federal and state agencies to ensure the impacts of climate change are adequately monitored and to support ecological research, management, assessment and policy. Existing tracking networks in the United States will need to improve coverage through time and in geographic area to detect and track climate-induced shifts in ecosystems and species.

     Background:

    Federal law requires that the U.S. Global Change Research Program submit an assessment of climate change and its impacts to the President and the Congress once every four years. Technical reports, articles and books – such as this report — underpin the corresponding chapters of the Third U.S. National Climate Assessment, due out in 2013. This technical report is available at the USGCRP website, as are other completed technical reports. Additional lead authors of this report include Shawn Carter, USGS: F. Stuart Chapin III, University of Alaska, Fairbanks; Peter Kareiva, The Nature Conservancy; and Mary Ruckelshaus, Natural Capital Project.

  • New From NAP 2012-12-18 00:00:00

    Final Book Now Available

    Higher education is a linchpin of the American economy and society: teaching and research at colleges and universities contribute significantly to the nation’s economic activity, both directly and through their impact on future growth; federal and state governments support teaching and research with billions of taxpayers’ dollars; and individuals, communities, and the nation gain from the learning and innovation that occur in higher education.

    In the current environment of increasing tuition and shrinking public funds, a sense of urgency has emerged to better track the performance of colleges and universities in the hope that their costs can be contained without compromising quality or accessibility. Improving Measurement of Productivity in Higher Education presents an analytically well-defined concept of productivity in higher education and recommends empirically valid and operationally practical guidelines for measuring it. In addition to its obvious policy and research value, improved measures of productivity may generate insights that potentially lead to enhanced departmental, institutional, or system educational processes.

    Improving Measurement of Productivity in Higher Education constructs valid productivity measures to supplement the body of information used to guide resource allocation decisions at the system, state, and national levels and to assist policymakers who must assess investments in higher education against other compelling demands on scarce resources. By portraying the productive process in detail, this report will allow stakeholders to better understand the complexities of–and potential approaches to–measuring institution, system and national-level performance in higher education.

    [Read the full report]

    Topics:

  • Future Uses of the Department of Defense Joint Pathology Center Biorepository

    Cover imageFounded during the Civil War as the Army Medical Museum, the Armed Forces Institute of Pathology (AFIP) amassed the world’s largest collection of human pathologic specimens and was considered a premier consultation, education, and research facility by the end of the 20th century. Samples from the AFIP were instrumental in helping to solve public health mysteries, such as the sequence of the genome of the 1918 influenza virus that killed more than 40 million people worldwide.

    In 2005, the federal Base Realignment and Closure Commission recommended that the AFIP be closed, and its biorepository was transferred to the newly created Joint Pathology Center. During the transition, the Department of Defense asked the IOM to provide advice on operating the biorepository, managing its collection, and determining appropriate future use of specimens for consultation, education, and research.

    Future Uses of the Department of Defense Joint Pathology Center Biorepository, the IOM proposes a series of protocols, standards, safeguards, and guidelines that could help to ensure that this national treasure continues to be available to researchers in the years to come, while protecting the privacy of the people who provided the materials and maintaining the security of their personal information.

  • Determining Core Capabilities in Chemical and Biological Defense Science and Technology

    Cover imageThe goal of the U.S. Department of Defense’s (DoD’s) Chemical and Biological Defense Program (CBDP) is to provide support and world-class capabilities enabling he U.S. Armed Forces to fight and win decisively in chemical, biological, radiological, and nuclear (CBRN) environments. To accomplish this objective, the CBDP must maintain robust science and technology capabilities to support the research, development, testing, and evaluation required for the creation and validation of the products the program supplies.

    The threat from chemical and biological attack evolves due to the changing nature of conflict and rapid advances in science and technology (S&T), so the core S&T capabilities that must be maintained by the CBDP must also continue to evolve. In order to address the challenges facing the DoD, the Deputy Assistant Secretary of Defense (DASD) for Chemical and Biological Defense (CBD) asked the National Research Council (NRC) to conduct a study to identify the core capabilities in S&T that must be supported by the program.

    The NRC Committee on Determining Core Capabilities in Chemical and Biological Defense Research and Development examined the capabilities necessary for the chemical and biological defense S&T program in the context of the threat and of the program’s stated mission and priorities. Determining Core Capabilities in Chemical and Biological Defense Science and Technology contains the committee’s findings and recommendations. It is intended to assist the DASD CBD in determining the best strategy for acquiring, developing, and/or maintaining the needed capabilities.

  • Mining Waste Byproduct Capable of Helping Clean Water

    LEETOWN, W.Va.A byproduct resulting from the treatment of acid mine drainage may have a second life in helping clean waters coming from agricultural and wastewater discharges, according to a recent study by scientists from the U.S. Geological Survey Leetown Science Center.  

    The report, published in the Journal Water, Air, and Soil Pollution, shows that dried acid mine drainage sludge, or residuals, that result from treating acid mine drainage discharges can be used as a low-cost adsorbent elsewhere to efficiently remove phosphorus from agricultural and municipal wastewaters.  The phosphorus that has been adsorbed by the mine drainage residuals can later be stripped from the residuals and recycled into fertilizer.  The mine drainage residuals can be regenerated and reused for a number of additional treatment cycles.  Application of this novel, patented technology has the potential to simultaneously help to decrease acid mine drainage treatment costs, prevent degradation of aquatic ecosystems, and recycle valuable nutrients. 

    “This wonderful result shows the inventive application of some very sophisticated environmental chemistry to create a new life cycle for what otherwise would have been some problematic waste products,” said USGS Director Marcia McNutt. “It sets the bar high for future studies in environmental remediation.” 

    Acid mine drainage is produced whenever sulfide minerals associated with coal and metal deposits are exposed to air and moisture. The resulting acid and dissolved metals are toxic to most forms of aquatic life, and untreated acid mine drainage has impacted more than 5000 miles of streams in the Appalachian region, with associated economic impacts of millions of lost dollars in the tourism and sport fishing industries.  

    When acid mine drainage is remediated, it is neutralized with a base, such as limestone or lime, and an iron-rich sludge is formed that must be disposed of, sometimes at considerable cost.  The new process of using the sludge to filter wastewaters has the potential to reduce the need to dispose of the sludge, while providing an added and previously unknown benefit of using the residuals to effectively reduce phosphorus from wastewater discharges wherever needed.  

    Excess phosphorus releases to the environment from agricultural and municipal wastewaters have resulted in significant impairment of aquatic ecosystems such as the Chesapeake Bay and other bodies of water worldwide.  At the same time, as depletion of high-grade phosphorus-bearing deposits continues, the possibility of future shortages of fertilizer phosphorus has been suggested.  

    Current technology for the removal of phosphorus from wastewater consists of addition of aluminum or iron salts to precipitate and adsorb phosphorus, but this is too expensive for the low concentrations and high volumes often encountered in many wastewaters.  This new technology provides a more efficient and cost effective option. 

    “As environmental scientists, we kind of hesitate to use this analogy, but it really is like killing two birds with one stone,” says Philip Sibrell, lead author of the study. “This new technology could reduce or eliminate the need to dispose of acid mine drainage sludge, instead making that same sludge useful in addressing the urgent need to reduce the amount of phosphorus going into aquatic ecosystems; it’s a win-win situation.” 

    Study citation: 

    Sibrell, P. L. and Tucker, T. W.  2012.  Fixed bed sorption of phosphorus from wastewater using iron oxide-based media derived from acid mine drainage.  Water, Air and Soil Pollution, 223:5105-5117.

  • UCLA stem cell researchers receive more than $6 million in grants from state agency

    Two cardiology investigators from the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA have been awarded grants totaling more than $6 million from the California Institute of Regenerative Medicine (CIRM), the state’s stem cell agency.
     
    The young physician–scientists, Dr. Reza Ardehali and Dr. Ali Nsair, will use the CIRM funds to conduct leading-edge research into the developmental and molecular biology of stem cells in their efforts to advance regenerative medicine for heart disease. Their studies will help form the foundation for translational and clinical advances, enabling human stem cells to be used for potential therapies and as tools for biomedical innovation.
     
    The CIRM grants, known as New Faculty Physician Scientist Translational Research Awards, are given to clinician–scientists in the first six years of their first independent faculty appointments. The awards were announced Dec. 12 during the regular meeting of the CIRM Independent Citizens Oversight Committee at the Luxe Hotel in Los Angeles.
     
    Dr. Reza Ardehali

    Ardehali

    Dr. Reza Ardehali, an assistant professor of cardiology and a member of the Broad Stem Cell Research Center, was awarded more than $2.9 million for research to isolate heart stem cells derived from human embryonic stem cells — cells that can  become any cell in the body — to determine if these heart cells can be integrated successfully into the environment of a living heart or if they will function in isolation at a different pace.

     
    Ardehali uses an analogy: “The performance of a symphony can go into chaos if one member plays in isolation from all surrounding cues. Therefore, it is important to determine if the transplanted cells can beat in harmony with the rest of the heart and if these cells will provide functional benefit to the injured heart.”
     
    Ardehali will transplant the heart stem cells into injured hearts in an animal model to determine if the cells improve heart function. He also will perform detailed analysis of the electrical activities of the heart to determine how well the stem cells grow and integrate into new heart tissue. The success of this proposed project could lead to future clinical trials of stem cell therapy for heart disease.
     
    Dr. Ali Nsair

    Nsair

    Dr. Ali Nsair, an assistant professor of medicine and cardiology and a member of the Broad Stem Cell Research Center, was awarded more than $3 million for research using induced pluripotent stem cells — tissue-specific blood or skin cells that have been reprogrammed to become like human embryonic stem cells — to develop heart tissue cells known as cardiac progenitor cells. Once these cardiac progenitor cells are grown in the laboratory, they will be used to regenerate heart muscle damaged by heart attack.

     
    The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research: UCLA’s stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Broad Stem Cell Research Center is committed to a multidisciplinary, integrated collaboration among scientific, academic and medical disciplines for the purpose of understanding adult and human embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed toward future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine at UCLA, UCLA’s Jonsson Cancer Center, the UCLA Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science.
     
    For more news, visit the UCLA Newsroom and follow us on Twitter.

  • New From NAP 2012-12-14 08:45:29

    Final Book Now Available

    Since 1991, the National Research Council, under the auspices of the Board on Science, Technology, and Economic Policy, has undertaken a program of activities to improve policymakers’ understandings of the interconnections of science, technology, and economic policy and their importance for the American economy and its international competitive position. The Board’s activities have corresponded with increased policy recognition of the importance of knowledge and technology to economic growth. The goal of the this symposium was to conduct two public symposia to review and analyze the potential contributions of public-private partnerships and identify other relevant issues for the Department of Energy, Office of Vehicle Technologies, Energy Storage Team’s activities in the energy storage research and development area. The symposia will also identify lessons from these and other domestic and international experiences to help inform DoE as to whether its activities are complete and appropriately focused. Additional topics that emerge in the course of the planning may also be addressed. Building the U.S. Battery Industry for Electric Drive Vehicles: Summary of a Symposium gathers representatives from leading battery manufacturers, automotive firms, university researchers, academic and industry analysts, congressional staff, and federal agency representatives. An individually-authored summary of each symposium will be issued.

    The symposium was held in Michigan in order to provide direct access to the policymakers and industrial participants drawn from the concentration of battery manufacturers and automotive firms in the region. The symposium reviewed the current state, needs, and challenges of the U.S. advanced battery manufacturing industry; challenges and opportunities in battery R&D, commercialization, and deployment; collaborations between the automotive industry and battery industry; workforce issues, and supply chain development. It also focused on the impact of DoE’s investments and the role of state and federal programs in support of this growing industry. This task of this report is to summarize the presentations and discussions that took place at this symposium. Needless to say, the battery industry has evolved very substantially since the conference was held, and indeed some of the caveats raised by the speakers with regard to overall demand for batteries and the prospects of multiple producers now seem prescient. At the same time, it is important to understand that it is unrealistic to expect that all recipients of local, state, or federal support in a complex and rapidly evolving industry will necessarily succeed. A number of the firms discussed here have been absorbed by competitors, others have gone out of business, and others continue to progress.

    [Read the full report]

    Topics: | |

  • New From NAP 2012-12-14 08:45:15

    Final Book Now Available

    A committee under the auspices of the Board on Science, Technology, and Economic Policy (STEP), is conducting a study of selected state and regional programs in order to identify best practices with regard to their goals, structures, instruments, modes of operation, synergies across private and public programs, funding mechanisms and levels, and evaluation efforts. The committee is reviewing selected state and regional efforts to capitalize on federal and state investments in areas of critical national needs. Building the Arkansas Innovation Economy: Summary of a Symposium includes both efforts to strengthen existing industries as well as specific new technology focus areas such as nanotechnology, stem cells, and energy in order to better understand program goals, challenges, and accomplishments. As a part of this review, the committee is convening a series of public workshops and symposia involving responsible local, state, and federal officials and other stakeholders. These meetings and symposia will enable an exchange of views, information, experience, and analysis to identify best practice in the range of programs and incentives adopted. Drawing from discussions at these symposia, fact-finding meetings, and commissioned analyses of existing state and regional programs and technology focus areas, the committee will subsequently produce a final report with findings and recommendations focused on lessons, issues, and opportunities for complementary U.S. policies created by these state and regional initiatives.

    Since 1991, the National Research Council, under the auspices of the Board on Science, Technology, and Economic Policy, has undertaken a program of activities to improve policymakers’ understandings of the interconnections of science, technology, and economic policy and their importance for the American economy and its international competitive position. The Board’s activities have corresponded with increased policy recognition of the importance of knowledge and technology to economic growth. One important element of STEP’s analysis concerns the growth and impact of foreign technology programs.1 U.S. competitors have launched substantial programs to support new technologies, small firm development, and consortia among large and small firms to strengthen national and regional positions in strategic sectors. Some governments overseas have chosen to provide public support to innovation to overcome the market imperfections apparent in their national innovation systems. They believe that the rising costs and risks associated with new potentially high-payoff technologies, and the growing global dispersal of technical expertise, underscore the need for national R&D programs to support new and existing high-technology firms within their borders.

    [Read the full report]

    Topics: | |

  • Update regarding problems with "Egyptological"

    Kate and Andrea are very sad to announce that Egyptological will be unavailable for the forseeable future.  It has been targeted by a professional hacking group as part of an onslaught on Egypt-related web sites during the current unrest in Egypt.

    Although we have been in negotiations with the hackers, which seemed to be going well, they have now announced their intention of resuming hostilities against us.  They apparently see Egyptology sites such as ours as representing a form of political threat.

    Until we have been able to assess the level of damage inflicted upon our backup solution, and have been able to devise a new strategy for the future security of Egyptological, our site will remain unavailable.  We do not expect it to be recovered until the end of January.

    Please be aware, however, that we are fully committed to restoring Egyptological to its former state, together with the latest unpublished edition of the Magazine, and we are investigating the possibility of publishing a temporary archive at an earlier date.

    We recommend that anyone with similar web sites should upgrade their own security arrangements, as you may now be interpreted as representing a political or religious affiliation.

    Kind regards from both of us

    Andrea Byrnes and Kate Phizackerley
    Egyptological

  • The Future of Scientific Knowledge Discovery in Open Networked Environments: Summary of a Workshop

    Cover imageDigital technologies and networks are now part of everyday work in the sciences, and have enhanced access to and use of scientific data, information, and literature significantly. They offer the promise of accelerating the discovery and communication of knowledge, both within the scientific community and in the broader society, as scientific data and information are made openly available online. The focus of this project was on computer-mediated or computational scientific knowledge discovery, taken broadly as any research processes enabled by digital computing technologies. Such technologies may include data mining, information retrieval and extraction, artificial intelligence, distributed grid computing, and others. These technological capabilities support computer-mediated knowledge discovery, which some believe is a new paradigm in the conduct of research. The emphasis was primarily on digitally networked data, rather than on the scientific, technical, and medical literature. The meeting also focused mostly on the advantages of knowledge discovery in open networked environments, although some of the disadvantages were raised as well.

    The workshop brought together a set of stakeholders in this area for intensive and structured discussions. The purpose was not to make a final declaration about the directions that should be taken, but to further the examination of trends in computational knowledge discovery in the open networked environments, based on the following questions and tasks:

    1. Opportunities and Benefits: What are the opportunities over the next 5 to 10 years associated with the use of computer-mediated scientific knowledge discovery across disciplines in the open online environment? What are the potential benefits to science and society of such techniques?
    2. Techniques and Methods for Development and Study of Computer-mediated Scientific Knowledge Discovery: What are the techniques and methods used in government, academia, and industry to study and understand these processes, the validity and reliability of their results, and their impact inside and outside science?
    3. Barriers: What are the major scientific, technological, institutional, sociological, and policy barriers to computer-mediated scientific knowledge discovery in the open online environment within the scientific community? What needs to be known and studied about each of these barriers to help achieve the opportunities for interdisciplinary science and complex problem solving?
    4. Range of Options: Based on the results obtained in response to items 1-3, define a range of options that can be used by the sponsors of the project, as well as other similar organizations, to obtain and promote a better understanding of the computer-mediated scientific knowledge discovery processes and mechanisms for openly available data and information online across the scientific domains. The objective of defining these options is to improve the activities of the sponsors (and other similar organizations) and the activities of researchers that they fund externally in this emerging research area.

    The Future of Scientific Knowledge Discovery in Open Networked Environments: Summary of a Workshop summarizes the responses to these questions and tasks at hand.

  • The Case for International Sharing of Scientific Data: A Focus on Developing Countries: Proceedings of a Symposium

    Cover imageThe theme of this international symposium is the promotion of greater sharing of scientific data for the benefit of research and broader development, particularly in the developing world. This is an extraordinarily important topic. Indeed, I have devoted much of my own career to matters related to the concept of openness. I had the opportunity to promote and help build the open courseware program at the Massachusetts Institute of Technology (MIT). This program has made the teaching materials for all 2,000 subjects taught at MIT available on the Web for anyone, anywhere, to use anytime at no cost. In countries where basic broadband was not available, we shipped it in on hard drives and compact disks. Its impact has been worldwide, but it has surely had the greatest impact on the developing world. I am also a trustee of a nonprofit organization named Ithaca that operates Journal Storage (JSTOR) and other entities that make scholarly information available at very low cost.

    The culture of science has been international and open for centuries. Indeed, the scientific enterprise can only work when all information is open and accessible, because science works through critical analysis and replication of results. In recent years, as some scientific data, and especially technological data, have increased in economic value frequently has caused us to be far less open with information than business and free enterprise require us to be. Indeed, the worldwide shift to what is known as open innovation is strengthening every day.

    Finally, since the end of World War II, the realities of modern military conflict and now terrorism have led governments to restrict information through classification. This is important, but I believe that we classify far too much information. The last thing we need today, at the beginning of the twenty-first century, is further arbitrary limitations on the free flow of scientific information, whether by policies established by governments and businesses, or by lack of information infrastructure. For all these reasons, the international sharing of scientific data is one of the topics of great interest here at the National Academies and has been the subject of many of our past reports. This is the primary reason why this symposium has been co-organized by the NRC’s Policy and Global Affairs Division—the Board on International Scientific Organizations (BISO) and the Board on Research Data and Information (BRDI). The Case for International Sharing of Scientific Data: A Focus on Developing Countries: Proceedings of a Symposium summarizes the symposium.

  • Two PNNL researchers named American Physical Society Fellows

    Two scientists from the Department of Energy’s Pacific Northwest National Laboratory have been named Fellows of the American Physical Society. Wayne Hess and Hongfei Wang were recognized for their “exceptional contributions to the physics enterprise.”

    APS fellows are nominated by APS members and selected by the APS Council. Fellows are limited to no more than one half of one percent of the society membership, which currently stands at about 50,000.

    Hess and Wang will be recognized at the annual APS meeting in March in Baltimore.

    Wayne Hess

    Hess is known for research on how materials respond to light. These materials can be used to perform chemical reactions driven by light or to convert light into electricity. Some of these materials are based on tiny particles of silver or gold that can absorb light strongly and then use that light efficiently. Hess also develops materials to improve advanced scientific equipment such as synchrotron light sources and high resolution electron microscopes.

    Hess regularly mentors post-doctoral fellows and college students, working to engage them in collaborative efforts between theory and experimentation. He has authored or co-authored more than 90 journal articles.

    Hess earned a bachelor’s degree and doctorate in chemistry from the University of Colorado in Boulder, and a master’s degree from the University of Oregon in Eugene.

    Hongfei Wang

    Wang was recognized for his original contributions to the development of “nonlinear vibrational spectroscopy” — an advanced laser-based method for better understanding the structure and dynamics of chemical systems — and for improving the understanding of how molecules interact with each other and with structures at places where gas, liquid or solids intersect. His research has implications for environmental and biological processes, such as improving protective coatings and controlling drug interactions.

    In the past decade, Wang systematically developed the theory and experimental methodology in surface nonlinear vibrational spectroscopy. At EMSL, Wang custom-built the first spectrometer with unprecedented resolution that can characterize surfaces and interfaces in ways never before possible. Together with the theory and methodology he had developed, this instrument provides deeper understanding of chemistry at surfaces and interfaces that are ubiquitous in natural and industrial processes. Such detailed knowledge can lead to building better solar cells and better catalysts for alternative energy.  This new instrument is available to the broad scientific community at EMSL, the Environmental Molecular Sciences Laboratory, a user facility at PNNL.

    Wang earned a bachelor’s degree in chemical physics at University of Science & Technology in China, and master’s and doctorate degrees in chemistry from Columbia University. Before joining PNNL in 2009, he was a research professor at the Institute of Chemistry in the Chinese Academy of Sciences at Beijing for 10 years.

    Hess and Wang join nine other PNNL staff as APS Fellows — Liem Dang, Michel Dupuis, Jean Futrell, Bruce Garrett, Bruce Kay, Greg Kimmel, Greg Schenter, Lou Terminello and Sotiris Xantheas.


    The American Physical Society is a non-profit membership organization working to advance and diffuse the knowledge of physics through its outstanding research journals, scientific meetings, and education, outreach, advocacy and international activities. APS represents 50,000 members, including physicists in academia, national laboratories and industry in the United States and throughout the world. Society headquarters are located in College Park, Md.

  • UCLA, First 5 LA partner to provide vision services for county’s most vulnerable preschoolers

    Young children in Los Angeles County who are in need of vision services will soon be seeing things a lot clearer, thanks to a new collaboration between the Jules Stein Eye Institute at UCLA and First 5 LA, the child advocacy and grant-making organization. 
     
    The UCLA Mobile Eye Clinic, an outreach program of the Jules Stein Institute, has received an allocation of $4.1 million from the First 5 LA commission that will be used to screen more than 90,000 children between the ages of 3 and 5 from underserved populations in the county over the next five years. 
     
    Under the collaboration, the UCLA Mobile Eye Clinic will provide services to preschoolers, including initial vision screenings at preschool locations; full-eye exams conducted by ophthalmologists and optometrists for children who fail the initial exam; referrals to partner specialists for visually impaired children who need special medical or surgical treatment; and free eyeglasses for those with refractive errors. 
     
    Additionally, the mobile clinic has an automated scheduling, coordination and data-registration program that makes it easy for parents to schedule appointments, and the clinic’s staff will work hand-in-hand with preschool teachers and parents to ensure follow-up care and compliance.
     
    “Much of children’s health and learning abilities is greatly dependent on their sight,” said Dr. Anne L. Coleman, who directs the Mobile Eye Clinic and the Jules Stein Eye Institute Center for Community Outreach and is vice chair of academic affairs for the UCLA Department of Ophthalmology. “It is estimated that one in five preschool children has a vision problem that
     
    affects their learning ability. Improving vision in these children not only helps improve their academic performance, but it also protects them from environmental hazards and enhances the quality of their social and personal lives.”
     
    “The Jules Stein Institute is dedicated to the preservation and restoration of vision worldwide,” said Dr. Bartly J. Mondino, the institute’s director and chair of the UCLA Department of Ophthalmology since 1994. “The First 5 collaboration supports the Jules Stein Eye Institute’s mission, part of which is to address the needs of some of the most vulnerable in Los Angeles County who are at risk of losing their sight unnecessarily.”
     
    The Jules Stein Eye Institute at UCLA is a vision science campus dedicated to the preservation and restoration of vision through its global programs in innovative research, quality patient care, and multidisciplinary and integrative education. The institute’s community outreach efforts range from its Mobile Eye Clinic, which travels to schools, shelters, health fairs and other organizations that assist homeless and low-income families, to programs like Vision IN-School, for vision education; Shared Vision, for the collection and  donation of used eyeglasses; the Preschool Vision Screening program; and the Indigent Children and Families program. For more information or to make an appointment, call 310-825-5000 or visit www.jsei.org.
     
    For more news, visit the UCLA Newsroom and follow us on Twitter

  • New From NAP 2012-12-13 10:45:01

    Final Book Now Available

    Digital technologies and networks are now part of everyday work in the sciences, and have enhanced access to and use of scientific data, information, and literature significantly. They offer the promise of accelerating the discovery and communication of knowledge, both within the scientific community and in the broader society, as scientific data and information are made openly available online. The focus of this project was on computer-mediated or computational scientific knowledge discovery, taken broadly as any research processes enabled by digital computing technologies. Such technologies may include data mining, information retrieval and extraction, artificial intelligence, distributed grid computing, and others. These technological capabilities support computer-mediated knowledge discovery, which some believe is a new paradigm in the conduct of research. The emphasis was primarily on digitally networked data, rather than on the scientific, technical, and medical literature. The meeting also focused mostly on the advantages of knowledge discovery in open networked environments, although some of the disadvantages were raised as well.

    The workshop brought together a set of stakeholders in this area for intensive and structured discussions. The purpose was not to make a final declaration about the directions that should be taken, but to further the examination of trends in computational knowledge discovery in the open networked environments, based on the following questions and tasks:

    1. Opportunities and Benefits: What are the opportunities over the next 5 to 10 years associated with the use of computer-mediated scientific knowledge discovery across disciplines in the open online environment? What are the potential benefits to science and society of such techniques?
    2. Techniques and Methods for Development and Study of Computer-mediated Scientific Knowledge Discovery: What are the techniques and methods used in government, academia, and industry to study and understand these processes, the validity and reliability of their results, and their impact inside and outside science?
    3. Barriers: What are the major scientific, technological, institutional, sociological, and policy barriers to computer-mediated scientific knowledge discovery in the open online environment within the scientific community? What needs to be known and studied about each of these barriers to help achieve the opportunities for interdisciplinary science and complex problem solving?
    4. Range of Options: Based on the results obtained in response to items 1-3, define a range of options that can be used by the sponsors of the project, as well as other similar organizations, to obtain and promote a better understanding of the computer-mediated scientific knowledge discovery processes and mechanisms for openly available data and information online across the scientific domains. The objective of defining these options is to improve the activities of the sponsors (and other similar organizations) and the activities of researchers that they fund externally in this emerging research area.

    The Future of Scientific Knowledge Discovery in Open Networked Environments: Summary of a Workshop summarizes the responses to these questions and tasks at hand.

    [Read the full report]

    Topics:

  • New From NAP 2012-12-13 00:00:00

    Final Book Now Available

    Founded during the Civil War as the Army Medical Museum, the Armed Forces Institute of Pathology (AFIP) amassed the world’s largest collection of human pathologic specimens and was considered a premier consultation, education, and research facility by the end of the 20th century. Samples from the AFIP were instrumental in helping to solve public health mysteries, such as the sequence of the genome of the 1918 influenza virus that killed more than 40 million people worldwide.

    In 2005, the federal Base Realignment and Closure Commission recommended that the AFIP be closed, and its biorepository was transferred to the newly created Joint Pathology Center. During the transition, the Department of Defense asked the IOM to provide advice on operating the biorepository, managing its collection, and determining appropriate future use of specimens for consultation, education, and research.

    Future Uses of the Department of Defense Joint Pathology Center Biorepository, the IOM proposes a series of protocols, standards, safeguards, and guidelines that could help to ensure that this national treasure continues to be available to researchers in the years to come, while protecting the privacy of the people who provided the materials and maintaining the security of their personal information.

    [Read the full report]

    Topics: |

  • Aging and the Macroeconomy: Long-Term Implications of an Older Population

    Cover imageThe United States is in the midst of a major demographic shift. In the coming decades, people aged 65 and over will make up an increasingly large percentage of the population: The ratio of people aged 65+ to people aged 20-64 will rise by 80%. This shift is happening for two reasons: People are living longer, and many couples are choosing to have fewer children and to have those children somewhat later in life. The resulting demographic shift will present the nation with economic challenges, both to absorb the costs and to leverage the benefits of an aging population.

    Aging and the Macroeconomy: Long-Term Implications of an Older Population presents the fundamental factors driving the aging of the U.S. population, as well as its societal implications and likely long-term macroeconomic effects in a global context. The report finds that, while population aging does not pose an insurmountable challenge to the nation, it is imperative that sensible policies are implemented soon to allow companies and households to respond. It offers four practical approaches for preparing resources to support the future consumption of households and for adapting to the new economic landscape.

  • Reusable Booster System: Review and Assessment

    Cover imageOn June 15, 2011, the Air Force Space Command established a new vision, mission, and set of goals to ensure continued U.S. dominance in space and cyberspace mission areas. Subsequently, and in coordination with the Air Force Research Laboratory, the Space and Missile Systems Center, and the 14th and 24th Air Forces, the Air Force Space Command identified four long-term science and technology (S&T) challenges critical to meeting these goals. One of these challenges is to provide full-spectrum launch capability at dramatically lower cost, and a reusable booster system (RBS) has been proposed as an approach to meet this challenge.

    The Air Force Space Command asked the Aeronautics and Space Engineering Board of the National Research Council to conduct an independent review and assessment of the RBS concept prior to considering a continuation of RBS-related activities within the Air Force Research Laboratory portfolio and before initiating a more extensive RBS development program. The committee for the Reusable Booster System: Review and Assessment was formed in response to that request and charged with reviewing and assessing the criteria and assumptions used in the current RBS plans, the cost model methodologies used to fame [frame?] the RBS business case, and the technical maturity and development plans of key elements critical to RBS implementation.

    The committee consisted of experts not connected with current RBS activities who have significant expertise in launch vehicle design and operation, research and technology development and implementation, space system operations, and cost analysis. The committee solicited and received input on the Air Force launch requirements, the baseline RBS concept, cost models and assessment, and technology readiness. The committee also received input from industry associated with RBS concept, industry independent of the RBS concept, and propulsion system providers which is summarized in Reusable Booster System: Review and Assessment.

  • Fitness Measures and Health Outcomes in Youth

    Cover imagePhysical fitness affects our ability to function and be active. At poor levels, it is associated with such health outcomes as diabetes and cardiovascular disease. Physical fitness testing in American youth was established on a large scale in the 1950s with an early focus on performance-related fitness that gradually gave way to an emphasis on health-related fitness. Using appropriately selected measures to collected fitness data in youth will advance our understanding of how fitness among youth translates into better health.

    In Fitness Measures and Health Outcomes in Youth, the IOM assesses the relationship between youth fitness test items and health outcomes, recommends the best fitness test items, provides guidance for interpreting fitness scores, and provides an agenda for needed research.

    The report concludes that selected cardiorespiratory endurance, musculoskeletal fitness, and body composition measures should be in fitness surveys and in schools. Collecting fitness data nationally and in schools helps with setting and achieving fitness goals and priorities for public health at an individual and national level.

  • Scientists find drug that may help in fight against Duchenne muscular dystrophy

    Drugs that are currently being tested show promise for treating patients with Duchenne muscular dystrophy, an inherited disease that affects about one in 3,600 boys and results in muscle degeneration and, eventually, death.
                          
    Now, scientists at UCLA have identified an additional drug — one that is already approved by the U.S. Food and Drug Administration and is being used in humans — that provides a powerful boost to the therapy now being tested in clinical trials. They hope that when used in combination, the drugs will provide a one-two punch that will overcome the genetic mutations that cause Duchenne muscular dystrophy (DMD), restore a missing protein needed for proper muscle function, and allow those affected by the disease to lead relatively normal lives.
     
    The drug, called dantrolene, was found after researchers examined thousands of small molecules using a high-throughput molecular screening technique that allows them to scrutinize many molecules at the same time, said the study’s senior authors, Dr. Stanley Nelson, a UCLA professor of human genetics, and Carrie Miceli, a UCLA professor of microbiology, immunology and molecular genetics.
     
    Dantrolene is a muscle relaxant that is used to treat malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. It is also used in the treatment of severe muscle spasms.
     
    “Dantrolene is such an attractive candidate to test in this disease, as it is already approved and has been used safely in humans for decades, and we won’t have to go through the lengthy and costly drug development process,” Nelson said. “We were very pleased to find out that this drug seems to work synergistically with the drugs being tested now on boys with DMD.”
     
    The study appears Dec. 12 in the peer-reviewed journal Science Translational Medicine.
     
    The research by Miceli and Nelson, who are married, is driven by more than just scientific curiosity. Their youngest son, Dylan, 11, was diagnosed with DMD in 2004. While he’s still ambulatory — many DMD patients require the use of wheelchairs by about age 10 — Dylan can no longer run or climb stairs, and he can’t shoot a basketball over his head like other boys his age. Despite these challenges, Miceli said Dylan remains a happy, funny and engaged boy, full of life and passion.
     
    “We entered into this field because of the diagnosis of our son, but we hope our research can help many others,” she said. “There are drugs that can help manage the symptoms of the disease but nothing that changes its course dramatically. We’re trying to correct the defect that causes DMD with highly personalized genetic medicine.”
     
    DMD is caused by mutations in the Duchene gene, which is located on the X chromosome and is necessary for correct muscle-cell function. These mutations prohibit production of the protein dystrophin, causing the muscles, as well as the heart and respiratory system, to deteriorate. An exon — a sequence of DNA — or multiple exons are deleted in the mutant gene, causing the cellular machinery to “skip over” the exon; what was once a readable genetic instruction is thus rendered unreadable.
     
    The drugs being tested in boys with DMD now use small pieces of DNA called antisense oligonucleotides that act as molecular “patches,” allowing for the production of dystrophin. The trials thus far have shown that the exon-skipping therapy is working. However not enough dystrophin is being produced for fully normal muscle function. Nelson and Miceli sought out molecules that could give a boost to the exon-skipping drugs so that DMD patients could produce enough dystrophin for more normal muscle function.
     
    Miceli and Nelson, members of the Broad Stem Cell Research Center at UCLA, used DMD patient–specific stem cells, reprogrammed them into muscle cells and then treated the cells with the exon-skipping drugs. The molecular screening technique then added the thousands of small molecules to the cells, and the results were analyzed by studying the treated cells to see which cells responded to which molecule. Dantrolene showed promise, Nelson said.
     
    In collaboration with Melissa Spencer, a professor of neurology at UCLA, the scientists tested the combination in a DMD mouse model. The animals were treated with dantrolene in combination with the exon-skipping drugs. The treated mice produced more dystrophin and showed improved muscle function. Tests showed the DMD mice treated with the combination therapy were significantly stronger than those that weren’t.
     
    DMD, the most common of childhood’s deadly DNA-linked diseases, generally leads to death by respiratory or heart failure in the teens or early 20s. Miceli and Nelson hope that their combination therapy could lead to longer life spans for boys with DMD.
     
    “Our hope is that these boys won’t have to die so young and suffer from the progressive muscle degeneration and the loss of mobility that they do now,” Miceli said. “We hope to find a therapy that at the least results in much more mild symptoms and delays by many years the onset of this disease.”
     
    Going forward, Nelson and Miceli will further their research with the goal of translating their findings from the bench to the bedside. The pair has received a $6 million grant from the California Institute for Regenerative Medicine to do longer-term studies of their drug combination therapy in mouse models to ensure that it can restore dystrophin levels to normal or near-normal levels. They also will explore whether DMD patients with other mutations can benefit from the combination therapy. They hope their work will result in clinical trials testing the exon-skipping drugs together with dantrolene or dantrolene-like drugs togetherin boys with DMD.
     
    “These findings highlight the value of combination therapies and the repurposing of FDA-approved medications as powerful translational strategies,” the study states.
     
    The seven-year study, conducted in three UCLA laboratories, was funded by the Foundation to Eradicate Duchenne, the Department of Defense and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. It was performed within the Center for Duchenne Muscular Dystrophy at UCLA.
     
    For more news, visit the UCLA Newsroom and follow us on Twitter.