No huge surprises here, folks.
CPI was benign, as core was flat.
Annualized housing starts were up 8.9%, which was basically in line with expectations.
Join the conversation about this story »
See Also:
SA44FVP76BKR
MCF-7 is a human breast cancer cell line that i will use in my Cancer Research. I am going to share some knowledge about this breast cancer cell line. I’m so sorry for not updating the Cytogenetics and Cancer Research blog for a week time. I just came back from joining a camp. I will continue my lab work start from tomorrow. Let us explore about MCF-7 now!
MCF-7 cell line was first derived from a pleural effusion of a post menopausal 69 years patient with metastatic breast cancer in 1970 (Rebecca et al., 2003). The MCF-7 cell line is the most widely used in cancer research and best characterized of all the human breast cancer cell lines (Dino et al., 2007).
MCF-7 cell line is useful as an investigative tool in laboratories worldwide in cancer research. It possesses the abilities to undergo DNA fragmentation. It also has differential sensitivities to estrogens and anti-estrogens, differential expression of estrogens receptor (ER), ER mRNA, and progesterone receptor, and differences in tumorigenicity and proliferation rates (Matthew et al., 2003). MCF-7 cells is the first hormone-responsive breast cancer cell line (Amanda et al., 2003).
The characteristics of MCF-7 cells like the estradiol-dependence for growth and low metastatic potential has led to the assumption that they represent an early epithelial adenocarcinoma of breast (John et al., 1995). MCF-7 cells are perfect model to study the pathway of malignant progression as they can be subjected to appropriate endocrinologic and physiologic selective pressures for the derivation of variants with more progressed phenotypes (Hans et al., 2007).
The epithelial breast cancer derived MCF-7 cell line is one of the most frequently used model systems for clinical studies. The researchers used it for the studies of breast cancer treatment. The clinical studies have shown that therapeutic agents preventing the synthesis and activity of estrogens are essential in the breast cancer treatment. The addition of extradiol which is one of the fractions of estrogen to the medium of MCF-7 cells induces a proliferative response (Irene et al., 2003).
There are apoptotic responses of MCF-7 cells to the apoptosis-inducing agents like tumor necrosis factor and anti-Fas antibody. The MCF-7 cells still remains as an excellent in vitro model for studying the mechanisms of chemoresistance because of its susceptibility to apoptosis (Richard et al., 2003).
Sources:
1. Rebecca S., Matthew B., Amanda P., Christopher W. & Barbara B. Apoptosis, Chemoresistance, and Breast Cancer: Insights from the MCF-7 Cell Model System. Exp Biol Med (Maywood) 228(9), 995-1003 (2003).
2. John J. P., Jiang S. Y., Michael F. & Jordan V. C. An Estrogen-Independent MCF-7 Breast Cancer Cell Line Which Contains a Novel 80-Kilodalton
MCF-7 – Human Breast Cancer Cell Line is a post from: Cytogenetics and Cancer Research
Global Witness today broadly welcomed a report from the Joint Committee on Human Rights (JCHR) and called on the UK government to heed the recommendations and do more to prevent UK companies operating overseas from being complicit in human rights abuses.
The report, Any of our business? Human rights and the UK private sector, lists several companies operating in conflict areas as being involved in grave human rights abuses. These include Afrimex and Amalgamated Metals Corporation (AMC), companies which trade in minerals from the Democratic Republic of Congo (DRC), about which Global Witness gave written and verbal submissions to the committee.
“This report is welcome but it highlights the inadequate action so far taken by the British government against companies who are violating human rights,” said Gavin Hayman, Campaigns Director at Global Witness. “It should act as a wake up call for tougher standards and better regulation of companies that exploit natural resources in conflict or high risk areas.”
Global Witness backed the report’s finding that there was an undue reliance on voluntary standards, which are often not enforced, and said that greater emphasis should be placed on legislative remedies. So far the UK Government has failed to take adequate action to prevent or deter abuses by UK companies operating in conflict areas, in particular in the DRC.
Global Witness’s submissions to the JCHR showed that UK companies operating in conflict or high risk areas are at a greater risk of committing and exacerbating human rights violations. In these places, there is often fighting and widespread repression, and governments are often unwilling or unable to assume their responsibilities in safeguarding human rights.
In August 2008, Afrimex was found by the UK National Contact Point (NCP) for the OECD Guidelines on Multinational Enterprises to have failed to ensure that its trading activities did not support armed conflict and forced labour in the eastern DRC. Despite this clear finding against Afrimex, the JCHR report says that the Government is still “considering how to follow up on a negative decision of the UK NCP.”
“The Government must make immediate efforts to make sure the National Contact Point’s final statements have more teeth, and that companies which continue to operate in violation of the OECD guidelines are duly sanctioned,” said Hayman.
The latest UN Group of Experts report on the DRC released in November 2009, states that a company closely affiliated with Afrimex is still operating in the DRC.
“With respect to Afrimex, the UK Government should have taken steps to sanction the company long before Global Witness’ intervention. These important cases should not be left to civil society to undertake: the Government must take a more proactive role,” said Hayman.
/ Ends
Contact: Seema Joshi +44 207 492 5890; Amy Barry +44 207 492 5858; +44 7980 664397
For more information on Global Witness’s work visit www.globalwitness.org
How cool is this? On minute Tom Smallwood is reeling after losing a (once) steady production job at General Motors’ Truck Plant in Pontiac, MI, and the next minute he takes the PBA championship. In a real-life event that mimics some of the great tales in the history of underdog turned champion, Smallwood took third in a PBA qualifier event, making him eligible for one year on the prestigious bowling tour.
That alone barely makes the story interesting, but the tale becomes far more compelling due to the fact that Smallwood rolled into Wichita, Kansas an also-ran and left holding the first place trophy and a $50,000 grand prize. Smallwood, a 15-year recreational bowler, even had to beat out PBA bowler of the year Wes “Big Nasty” Malott in the final round. The former GM line worker performed superbly under pressure by hitting two strikes in the decisive tenth frame to take the match 244-228. After Smallwood’s big win he was called by GM to take another plant job but the suddenly high-flying bowler turned down the offer in order to stick with his new profession.
We’re thinking Smallwood’s meteoric rise to the top of the bowling world will net him quite a bit more than his $50,000 top prize. Advertisers love a rags-to riches-story and Smallwood may be selling resin and those wrist things bowlers wear before you’re even finished reading this post. Congratulations Tom!
[Source: Kicking Tires]
Bowling for Michigan: Laid-off GM worker wins PBA championship originally appeared on Autoblog on Wed, 16 Dec 2009 08:30:00 EST. Please see our terms for use of feeds.
Read | Permalink | Email this | Comments
The site was down for a little while yesterday, so if you tried to enter the Watson t-shirt giveaway and got a weird error, please try again! Here’s the link.
I am a 28 year old, type 1 diabetic that was diagnosed 7/11/09. I have a great wife and 18mo. old daughter. I felt very loopy and flu-like that day (and a couple days before) when I went to the UrgentCare. I’ll never forget the doc saying "There’s no easy way to tell you this, but you’re diabetic and in DKA. I can’t release you to your wife, I must call an ambulance." Scary. My sugar was 375 and ketones were 1000+. I knew something was going on for a while, but didn’t know what. After 3 days in the hospital, I was sent home on insulin.
Now December, I am on a Minimed 722 with CGMS and love it. I use Novolog in the pump with no other meds. I was never given the chance for pills. In September my A1c was 6.9. I didn’t see the rest of the labs (peptide, etc.). I have been working closely with a great team of doctors medtronic trainers, diabetes educators and feel very positive about where I should be with control by summer.
It’s frustrating sometimes as I think scientifically and can’t get things under control as fast as I would like. However, I know that I can do it eventually and I have made healthy lifestyle changes due to the diagnosis (ones I needed to make anyway), so that is encouraging. I am down from 280lbs. to 220lbs., but the doc say that no matter how much weight I loose, I probably will be on insulin for life. I’m exercising more than I used to but am still having spikes and lows, which I’ll post about in other threads. I guess it took a while to get this way and you can’t fix it overnight, right?
Thanks for listening and for sharing your knowledge!! I look forward to see you all in the threads!
Two men walked out of prison yesterday across the country from one another, both victims of wrongful convictions. Their cases are quite different, but both shed light on a broken system that continues to incarcerate countless innocent people.
Donald Eugene Gates was freed in Arizona yesterday after 28 years in federal prisons for a 1981 Washington, D.C., murder that DNA now shows he didn’t commit. He was convicted based largely on the testimony of an FBI forensic analyst whose work was later discredited. The analyst testified that hairs from the crime scene were “microscopically indistinguishable” from Gates’ hairs — a gross exaggeration of the possibilities of hair science.
In Georgia, Michael Marshall was freed yesterday after serving two years in prison for a 2007 carjacking, based on DNA tests obtained by the Georgia Innocence Project showing that items left by the perpetrator did not belong to Marshall. The most disturbing part of Marshall’s case is that the items that now proved his innocence were available before his conviction, but nobody chose to test them. He pled guilty to the crime he didn’t commit “out of being scared,” he wrote to the Georgia Innocence Project. (Marshall is pictured at left leaving the courthouse yesterday with Georgia Innocence Project Intern Christina Rupp)
These two exonerations are bittersweet — two men are free for the holidays and their wrongful incarcerations have come to an end, but their freedom came with an immense cost. And they aren’t alone. Their exonerations demonstrate exactly why wrongful convictions are so common — and why they’ll continue if we don’t address the causes.
We’ve never been to American Idol, but this sounded awesome. Way more interesting and important.
Fortunately we found a few wire photos, and we can see what he means.
Rather than watching singers perform warmed over classics, watching Americans, Chinese, Russians, and Norwegians battle over multi-billion dollar oil fields is seriously good TV.
Join the conversation about this story »
See Also:
An industrious Italian Argentinian hacker named Rodrigofd over at MoDaCo using ginkage’s OpenGl v1 wrapper library has been working on porting the HTC HD2 ROM to the Samsung Omnia 2, and seems to have nearly perfected the process.
The above video shows his work in action and seems about 90% feature complete, and combine the best of Samsung and HTC’s work.
Read more at Hdblog.it here.
Thanks Giuseppe for the tip.
Recent studies have shown that — despite a massive recession — both the music and movie industries are having fantastic years. However, both industries are complaining about how they’re being “killed” by “piracy.” There’s no evidence of this of course, but when it comes to copyright, politicians don’t seem to believe evidence is necessary. They just spring into action. So, just as a bunch of Federal government representatives sat down for a private meeting with entertainment industry bosses, Congress agreed to earmark another $30 million to propping up their obsolete business models fighting “piracy.” It’s a nice deal. Copyright infringement should, by any honest definition of the term, be a civil issue, taken up between private parties. There is a criminal component to copyright law, but it makes little sense. However, now the Justice Department and other local officials have a pool of cash so that they can be the entertainment industry’s police force and private prosecutors.
Permalink | Comments | Email This Story
YouTube is, by far, the largest video site on the planet so if you want to know what were the hottest videos of 2009, there’s no need to look any further. And since this was the biggest year for online video ever, with month after month of record-breaking audiences, there were some pretty big hits out there, most of them completely unexpected, showing that YouTube hasn’t lost its touch.
“This year has been the biggest yet for online video, and for the first time we’re sharing our official Most Watched lists and some of the fastest-rising search terms on YouTube. Some moments were big (President Obama’s inauguration), some small (a Minnesota wedding party erupts into dance), some expected (“New Moon”), some surprising (Susan Boyle) — but all of them inspired, entertained and connected millions of people around the world via YouTube,” Jamie Davidson, associate product manager at YouTube wrote.
The biggest video this year, without any shred of doubt was Susan Boyle’s performance at Britain’s Got Talent which went on to get more than 120 million views so far this year, easily overtaking any other popular video even from the previous years. A distant second came the David after Dentist video which was streamed 37 million times. This summer’s most talked-about video, the JK Wedding Entrance Dance, g… (read more)
Yesterday we issued our twelve predictions for 2010. Once again, I’ll look back at our 2009 predictions and see how we did. (You can see how we assessed our 2008 predictions here.) The 2009 predictions were:
1. Open source ECM players get an initial boost
Yes, the recession gave them a boost, though smart customers are still asking tough questions about multi-year total cost of ownership.
2. Office14 casts long shadow on SharePoint
Yes, and no. SharePoint 2010 has energized Redmond’s consulting channel. The new version is mostly casting a long shadow on 3rd-party SharePoint add-ons and some enterprise procurement teams looking to delay strategic decisions.
3. "Taxonomies are dead. Long live metadata!"
Definitely less interest in complicated, human-maintained hierarchies.
4. Regulatory-compliance concerns reignited
Yes, though somewhat sector-specific.
5. Renewed interest in pro-active e-discovery
Not sure there was a major wave here in 2009. What do you think?
6. SaaS vendors expand offerings
Yes, though perhaps not as much as we predicted. Salesforce has certainly been active.
7. Oracle falls behind in battle for knowledge workers
Yes, but that was an easy one.
8. New emphasis on application search
I think so, but then again, we predict it again this year, albeit with some new twists.
9. Social computing diffuses into the Enterprise
Definitely.
10. Long-awaited consolidation comes to the WCM space
No way. What was I thinking?!?
11. Mobile and multimedia web analytics become key requirements…and disrupters
Multimedia for sure, mobile only half way.
12. Buyers remain in driver’s seat
Yes. This is another easy one. Just remember that vendors don’t chase every lead in this economy, either.
So, I give us a cumulative score of 9 out of 12, or pretty much the same average as last year. Maybe .75 is a good co-efficient to apply to our 2010 predictions.
Via The Real Deal, Mort Zuckerman popped by CNBC yesterday to talk commercial real estate, among other things. A key message. Big cities are actually holding up. Small cities. Not so good.
Join the conversation about this story »
See Also:
Content: Alien Breed Episode 1
Price: 800 Microsoft Points
Availability: All Xbox LIVE regions
Dash Text: Better get ready for some action! The 'breed' are back and must be stopped! Choose to go it alone or buddy up with a friend offline or online and take fight to the enemy in this fast-paced action horror set in a foreboding world of dread and terror. You will have to kick fear into touch if you are to fight your way through this myriad of challenges in order to complete this seat-of-the-pants adventure…Just remember to release the safety catch! There are no refunds for this item. For more information, see www.xbox.com/live/accounts.
Add Alien Breed Episode 1 to your Xbox 360 download queue
Aeroflex announced the 3280A Series spectrum analyzers with 30 MHz digital demodulator and generic vector demodulation as standard features with no price increase over its predecessor, the 3280 Series. Digital demodulation in the 3280A Series spectrum analyzers allows engineers to analyze the transmitter characteristics of wireless devices. The 3280A Series includes many optional measurement suites including WiMAX, WLAN, UMTS, CDMA2000, and GSM/EDGE.
The 3280A Series spectrum analyzers are accurate, flexible, and easy-to-use. By including a 30 MHz digital demodulator as standard, the 3280A Series provides even more functionality for the price—offering frequency coverage from 3 Hz to 26.5 GHz, impressive RF and microwave specifications, exceptional connectivity, and many ease-of-use features at an affordable price.
The 3280A Series maintains a high level of accuracy as its predecessor, ±0.15 dB up to 3 GHz. Other performance features include an excellent local oscillator (LO) phase noise <-115 dBm/Hz, 1GHz/ 10 kHz offset and +18 dBm third order intermodulation (TOI) performance. Digital intermediate frequency (IF) offers resolution bandwidths from 5 MHz to 1 Hz.
The Windows® XP operating system, internal hard drive and built-in CD-ROM make the 3280A Series easy to operate and allows for a wide range of interfaces, including LAN access, USB interface, RS-232, IEEE 488 (GPIB) and VGA outputs. Centronics parallel ports are provided for printer, mouse, and keyboard connectivity. An optional removable hard drive is available for when the instrument is used in a secure area.
The 3280A has a large 10.4 inch LCD display with ample viewing area, so data can be easily seen–even in split screen mode, or with multiple windows open. Three traces can be displayed per window and as many as nine markers can be selected with a marker table viewable in an alternate window.
Built-in functions can simplify the evaluation of many common measurements and the 3280A offers several of these, including: channel power, adjacent channel power, occupied bandwidth, spectrum emission mask, TOI measurement, harmonic distortion, X dB down, and phase noise measurement.
Delivery for the 3280A is 3 weeks upon receipt of order, pending option configuration. Pricing for the series depends upon selections of bandwidth and options. Contact your Aeroflex sales representative at (800) 853-2352 or [email protected] for more details.
Filed under: Government/Legal
The Mexican drug trade business is booming. Drugs are flowing between Mexico and the U.S. on a daily basis, overwhelming the Mexican military and U.S. border patrol officers. Most of the drugs arrive stateside via cars and trucks, and the vehicles transporting contraband range from a Rolls Royce to a VW Rabbit. The New York Times spent some time in Sinaloa, Mexico with Mexican General Federico Solórzano at what looked to be a used car lot.
The general’s troops have seized 766 vehicles to date ranging from Jaguars to brand new SUVs to classic muscle cars. Custom choppers, pickup trucks and sports cars are all accounted for on the lot, but these vehicles are different from cars and trucks you can purchase at your local dealership: they have secret compartments for carrying drugs and weapons across the Mexican boarder. The vehicles housed untold millions of dollars in addition to automatic weapons in false sidewalls, modified bumpers and trap doors. General Solórzano reportedly told the NYT that vehicles have been retrofitted with bullet-proofing tech, machine gun turrets, secret compartments that hold sharp nails for police cruisers in hot pursuit and even a smoke machine to assist in losing the Federalis.
The vehicles are being stored at a military base because drug traffickers have raided police facilities and took back the vehicles seized near the border. In total, the Mexican government is said to have over 14,000 vehicles in its possession, yet tons of drugs make the trip from South America to the U.S. without detection. The vehicles will eventually be sold at auction or will be used by other federal agencies, but the apparent crawl of the Mexican legal system means trials are sometimes years away. Head over to the NYT to read more about the vehicles that bring drugs from the Mexican boarder to a town near you. Pretty interesting stuff. Top tip, Mehul!
[Source: New York Times | Image: Jesus Alcazar/AFP/Getty Images]
How They Roll: NYT investigates the wheels of Mexican drug cartels originally appeared on Autoblog on Wed, 16 Dec 2009 07:59:00 EST. Please see our terms for use of feeds.
Read | Permalink | Email this | Comments
Content: Puzzlegeddon
Price: 800 Microsoft Points
Availability: All Not Available in Australia, India, Japan, Korea or New Zealand
Dash Text: Set in an array of galaxies, Puzzlegeddon™ features a clever mix of puzzle, action and strategy in a game that is fast-paced and addictive! Compete for the top spot on the planet by creating multiple combos for the quickest way to gather enough resources to blast your enemies out of this world! There are no refunds for this item. For more information, see www.xbox.com/live/accounts.
Add Puzzlegeddon to your Xbox 360 download queue
The UN Climate Change Conference is entering the decisive phase, as heads of state and government begin to arrive for the final few days of negotiations.
While UN Secretary General Ban Ki-moon is saying the leaders are facing a “defining moment in history”. British Prime Minister Gordon Brown, offers a more sobering assessment stating the deal “faces problems” and wonders if a deal will be reached at all.
There are many reports coming out of the Danish capital, suggesting that mood inside the conference is just as hostile as outside where police and protestors continue clash.
Politicians are already starting to manage the worlds expectations, and suggest the deal, if any will not be close to ideal.
Danish minister Connie Hedegaard said in her address “in these very hours, we are balancing between success and failure. Success is within reach, but, I must also warn you, we can also fail”. Even the normally positive UN Secretary General is sounding a little defeated, stating “three years of effort have come down to three days of action. Let us not fail in the home stretch. No one will get everything they want in this negotiation”.
Australian Prime Minister Kevin Rudd, who is in Copenhagen without parliamentary approval of his proposed carbon trade laws, said “I think to land a strong agreement in Copenhagen we are going to have to see more compromise all round, from big developed economies as well as the emerging economies. We’ve got a lot of work ahead of us”.
It always worries me when politician’s who by in large have spent most of their careers in some form of negotiation, come out and make obvious statements. It feels like the “spin machine” is hard at work.
Given the name calling between super-power nations, leaders of delegations walking out in anger, you begin to sense that the globe will be getting a lump of coal in their stocking this Christmas.
In other developments.
South Korea announced it will cut its greenhouse gas emissions by four percent by 2020 compared to 2005 levels. This makes the country the first emerging economy to take on an absolute reduction commitment and not only a relative commitment compared to a business as usual scenario.
When Japanese Prime Minister Yukio Hatoyama lands in Copenhagen he will have very big bundle of cash with him. It is reported that Japan is ready to invest $10 billion US dollars to help developing countries fight global warming. Japan is the worlds fifth largest emitter of greenhouse gases.
California Governor Arnold Schwarzenegger in a speech Tuesday he encouraged international agreements, but also said they wont be enough to combat global warming. “The worlds governments alone cannot make the progress that is needed on global climate change. They need the cities, the states, the provinces, the regions. They need the corporations, the activists the scientists, the universities” said Schwarzenegger.
Three days to go, and by most accounts, a lot of work left to be done.
share:
related.posts:
This smart idea from Andrew lets you build the Stolmen bike stand on carpet flooring. Sturdy enough to hold two bikes in mid air.
“This Ikea-hack is mainly an extension of a design already featured, that adapts said design to more applications. The Stolmen Bike Stand seemed like such a great idea, I wanted to make a similar one for my apartment. The basic design is the same, with one significant change: an adapter to use the Stolmen post on carpet.
Normally, the Stolmen posts are only good for wood floors, as the post is held by compression between the floor and ceiling. Using the standard base on carpet, the carpet compresses over time causing the pole to become loose and eventually fall (a well documented issue). The version I made eliminates this problem by replacing the bottom connection with a different design.
Items used:
– 4″ diameter, 1″ thick aluminum round (from Alro metals supply store)
– “Speaker Cabinet 3/8″ Toe Spike Set” from PartsExpress (p/n 240-725)
Instructions:
1. Drill a 1/2 inch diameter hole, 1/2″ deep, into the center of one side of the aluminum round.
2. On the other side of the aluminum round, drill and tap four holes for 1/4-20 thread pattern
3. Install speaker spikes in threaded holes.
4. Use base instead of standard Stolmen base, placing the extendable metal nob from the post into the 1/2″ diameter hole.
This design works because, as you tighten the post (using standard Ikea assembly methods), the speaker spikes drive through the carpet base and into the wood subfloor. This gives them a solid, non-giving, surface and allows the pole to be tightened properly and not fall over.”
Related hack:
– Bike extension for pizza delivery
The Chinese government does not like internet porn. So they are now paying people to surf the web to find it. Makes sense, no?
Shocking as it may sound, this well thought out government plan has actually encouraged people to search for porn more than before. Within 24 hours of the government announcing its incentive program, the Internet Illegal Information Reporting Center received more than 500 phone calls and 13,000 online responses, according to Xinhua, the state news agency.
The Chinese censors are offering as much as 10,000 yuan – nearly $1,500 U.S. dollars (!) – to the first person who reports a sexually obscene site. Sign me up!
This is only the latest round in China’s attempt to weed out evil porn sites. Earlier this year Chinese authorities publicly sanctioned Google for not filtering out porn from its search results. Of course, seasoned porn hounds know that Microsoft’s Bing is the best search engine for porn.
However, the government has backed down – for now – from a program known as Green Dam, which would have installed monitoring software on every computer sold in the country. A small step for porn, a giant leap for horny Chinese men.
photo credit: PinkMoose
Related posts:
