The new SP1500: bigger, better, faster, stronger
– working area of 1500 x 1250 mm (59 x 49″)
– Trotec IPC – Intelligent Path Control
– up to 400 watt laser power
Working Area + Speed + Productivity + Life span = Profitability
The SP1500 to the most profitable laser cutting and engraving system in its class. It combines highest productivity, a working area of a standard acrylic sheet size, highest system life span and lowest maintenance costs.
Tamoxifen plays an essential role as adjuvant drug in breast cancer treatment. Many people do not know about the mechanism how it functions to prevent the progression of breast cancer. I have found a lot of information about the Tamoxifen to share with all of you.
As what we know, Tamoxifen works to occupy the estrogen receptor and blocks the estrogen. In fact, there is another mode of action to treat the breast cancer instead of just blocking the estrogen. It also works in estrogen-receptor negative breast cancer and progesterone-receptor positive breast cancer. Instead of just blocking the estrogen, it also blocks another type of signal known as Protein Kinase C (PKC). PKC is essential in regulation of activation of oncogenes. By blocking the PKC, the oncogenes will not be activated. Besides, PKC also regulates other signals that control the growth and transformation of cells.
Furthermore, Tamoxifen is able to interfere with the cell cycle too. This is another anti-cancer action of it. As we all know, cell cycle is a predetermined program that leading the cell goes through the division. Normally, the cell cycle will be stopped at the checkpoints to ensure everything is in normal condition. The checks will ensure that the abnormal cells do not replicate. However, the cancer cells have abnormal cell cycles where they lost those checkpoints. Therefore, the cancer cells can replicate without any barrier. Consequently, the traditional chemotherapy is to restore the checkpoint function in cancer cell to stop the cell cycle. Significantly, Tamoxifen is one of the good drugs to be used as chemotherapeutic agent as it can stop the cell cycle in cancer cells.
In the previous post about the hormonal therapy for breast cancer treatment, I have mentioned that Tamoxifen can only work at 2 years. After 2 years, the drug will start to enhance the developing of tamoxifen-dependent cancer. We called this problem as Tamoxifen Resistance. Many cancer researches show that Tamoxifen Resistance is because of the permanent damage caused by the drug. It might damage the tumour suppressor gene, p53. p53 is a main role to stop the cell cycle and prevent the cancer cells to replicate. According to cancer research, p53 regulates the cell cycle when there are abnormal cells and cause them to apoptosis. Tamoxifen may stop p53 from working.
In conclusion, Tamoxifen is an effective drug to regulate the development of breast cancer only with the appropriate used. We need to get the advices from the oncologist before consuming it.
Tamoxifen – Breast Cancer Treatment is a post from: Cytogenetics and Cancer Research
The heavily anticipated Apple iPad was launched over the weekend and the public response, as expected, has been huge, with the device selling in the hundreds of thousands. It’s understandable, then, why everybody is interested in catering for the new, must-have device, Google included. Despite not being in the best of terms with Apple, the two giants … (read more)
Blu-ray Discs are getting a step-up, after the Blu-ray Disc Association announced two new specs for the format—BDXL, and IH-BD. There’s bad news however—you’ll need to buy a new player/recorder to use the 128GB discs. More »
At Whole Foods the other day, I was in the bulk foods section and saw these unique looking nuts. I thought the nuts would be a cool new thing to try. These reddish skinned nuts are called Wild Jungle peanuts and they are raw and organic and are from the forests of the Amazon, including the southern area of Ecuador.
Here are some health benefits of the Wild Jungle peanut. The one benefit that intrigued me the most was that these peanuts contain 26% protein- more than virtually any other nut or
seed, including flax or hemp. Now that is what I call a power food!
The peanuts themselves are not oily like regular peanuts and they are more fleshy because they are bigger in size. I really liked these peanuts and would like to try them ground into a nut butter.
For just a regular snack, I mixed the Wild Jungle peanuts with some dried cherries, black figs, and walnuts. The nice thing about this nut & dried fruit mix is that it’s full of fiber and protein along with some sweetness which is helping me on the sugar wean.
I enjoyed these Wild Jungle peanuts and are definitely getting more to nosh on.
(AFP/Getty Images/Matt Sullivan)
Overnight the mine disaster in West Virginia has become even worse.
Rescue teams planned to search again for four workers missing in a coal mine where a massive explosion killed 25 in the worst U.S. mining disaster in more than two decades, though officials said Tuesday that the chances were slim that the miners survived.
All the deaths were tragic, of course, and poignant:
Benny R. Willingham, 62, who was five weeks away from retiring, was among those who perished, said his sister-in-law Sheila Prillaman.
He had mined for 30 years, the last 17 with Massey, and planned to take his wife on a cruise to the Virgin Islands next month, she said.
And not surprisingly:
Though the cause of the blast was not known, the operation run by Massey subsidiary Performance Coal Co. has a history of violations for not properly ventilating highly combustible methane gas, safety officials said.
THINK has chosen New York as the first port of call in its push to capture a slice of the electric-vehicle market in the United States. The 100 mile range THINK City Electric Car will be rolled-out in New York and “other select cities” later this year with plans to begin manufacturing the THINK City in Elkhart, Indiana from early 2011…
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You’ve heard of the location, now it’s time to know about the settlers. Square Enix has now revealed more information regarding the five new clans that you’ll find in the realm of Eorzea, the place to be
If Supreme Court justice John Paul Stevens retires, and is replaced by Elena Kagan (the favorite), then the Supreme Court of the United States of America will have no Protestants on the bench. This in a nation which is 50% Protestant. Until after World War II the United States of America was in its self-identity fundamentally Protestant (see American Judaism and Catholicism and American Freedom for histories of how Jews & Catholics entered the American religious mainstream in the middle of the 20th century after a century of rejection by the Protestant establishment).* This is clear when you read about attempts to “Christianize” Roman Catholic Filipinos after the conquest of that nation from Spain in the early 20th century, or the reality that both American Catholicism and Judaism were often torn by conflicts between explicit assimilationists who wished to emulate the Protestant congregational model dominant in the United States, and those which argued for the perpetuation of a separate distinctive religious culture outside of the mainstream. And yet today this doesn’t matter much because the assimilationists won. Consider the fact that Stephen Breyer, who is Jewish, has a daughter who is an Episcopal priest (her mother is an English Anglican). Sonia Sotomayor is likely to be indistinguishable from the other Left-leaning justices, though she shares a Roman Catholic confession with the conservatives on the court. Religion in the United States by and large has become a personal label which serves as a marker toward one’s origins and one’s current loyalties, rather than a confession which indicates identity with a “thick” and exclusive subculture (the Amish, Hasidic Jews and Fundamentalist Mormons being exceptions). In this way the United States is like South Korea or many African nations, where religious pluralism and individual fluidity in choice and identity are the rule and not the exception.
The contrast with race and sex is notable. The predominance of males and whites on the bench is often commented on, but less so the fact that Roman Catholics are overrepresented by a factor of three, and Jews by nearly an order of magnitude. In fact, there seem to be a dearth of white Protestants at the pinnacles of American politics today. In the Congressional leadership Harry Reid is a Mormon, Nancy Pelosi & John Boehner are Roman Catholic. Steny Hoyer and Mitch McConnell “represent” for white Protestants, but the Vice President is a Roman Catholic.
* It is correct that many of the Founding Fathers, most famously Thomas Jefferson, were not orthodox Christians. But they were cultural Christians, more specifically cultural Protestants, and particularly of the denominations of their ancestors. Jefferson and George Washington were affiliated in some way throughout their life with the Episcopal Church of the Virginia gentry. John Adams was a Unitarian Christian whose outlook was shaped by the origins of Unitarianism in New England as a liberal reform movement within Congregational Calvinist Christianity. As such, the Founders shared Protestant suspicions of the Roman Catholic Church, whether it be due to Reform Christian antagonism of old or a newer Enlightenment anti-clericalism. Recall that one of the causa belli for colonial rebellion against the British crown was the toleration given to French Roman Catholics in Canada (this was later discretely removed from enumerations of causes because of the possibility that Quebec would join the rebellion, as well as the need for alliance with Roman Catholic France).
The Mentor ‘IDEAS for Mechanical’ site allows users of FloTHERM, FloVENT, FloTHERM PCB and FloEFD to post their software enhancement requests (access via their SupportNet login credentials), comment on other people’s and most importantly vote on those ideas that they believe would be of benefit to them. The result is a prioritised list of possible software features that product management can use to help determine a short term roadmap of the products that has the best chance of ensuring continued satisfaction of the userbase. (more…)
Interesting take on a camera bag. Could be handy on short shoots where you aren’t carrying a lot of gear.
It’d only get you 20 points, mind. Mattel, the Willy Wonka-esque makers of most board games, has relented under the pressure of unimaginative word sleuths by allowing pronouns onto the checkered boards. More »
This post is the fourth in an ongoing series highlighting the artists behind the SculptCAD Rapid Artists Project. (Hit this link for all posts related to the project.)
Brad Ford Smith is a Dallas-based artist and a third generation Texan. His abstract organic forms focus on how the eye and mind translate information, and how that visual experience can be altered by the passing of time. Brad’s works on paper and wall sculptures have been exhibited throughout Dallas and Chicago, where he resided shortly after earning his BFA in painting and printmaking from the Kansas City Art Institute.
In addition to making art, Brad is a professional member of the American Institute of Conservation. He specializes in the restoration of wooden artifacts.
How did you get involved with the RAPID Artists project?
Heather Gorham (ed, note: also a RAPID Artists project participant) introduced me to the folks at SculptCAD about eight years ago. I instantly saw how this 3D modeling program could open up a new world of fabrication options. It has been on my list of must do ever since.
Is this your first experience with 3D/digital sculpting technology and tools?
Other than that first introduction eight years ago, I have kept tabs on the subject, but this is the first time for me to use/learn the program.
How have these technologies changed the way you approach your process?
The challenge is learning how to use the tools, and then using those tools to create in an artistic manner. With each new tool there is the temptation to get carried away with all the new things that that tool offers. For example, the spin tool will take any wiggly profile and spin it on an axis to create a solid form. I played with this tool for an hour or so, creating some really wonderful shapes, but in the end, those shapes were only about using the tool and not about artistic expression. Managing the WOW factor has been tricky.
Are these digital tools a net positive, a net negative or entirely neutral in your artistic process?
I really love learning new processes. They always offer new ways to see and manipulate the world. The only negative is that this sculpture represents the FIRST work of art that I have made using this process, therefore it represents a large learning curve. Hopefully I will have more opportunities to use this technology in the future.
What are your thoughts on the SculptCAD Rapid Artists Project?
When Nancy (Hairston, SculptCAD founder) asked me to be part of this project, and I saw the list of artists involved, I was very excited and honored. Even though the artists in the SCRA project come from a wide range of artistic directions and disciplines, we are all connected by using/learning this technology. That has given us a common thread to build our conversations upon, which has lead to some great insight on the creative process.
Looking beyond the project, what do you have coming up in the near future art-wise? Do you have any shows or projects planned?
As soon as I get my 3D computer sculpture sent off to the printer, I am off to Italy to spend some quality time looking at sculptures made the old fashion way. After that I will be creating a book of my drawings using the iPhoto book program, and then looking for a venue to install a few wall sculptures in.
How can people interested in your work get in touch with you?
You can see more of my artwork as well as links to my blog and flicker site at www.BradFordSmith.us
Do you have any final thoughts on the SculptCAD Rapid Artists Project?
After seeing the first round of sculptures come back from the printers last week, I am really excited about how all the artwork will look when shown together. I am also very interested in the reactions of the people who will see this group exhibit at the RAPID Prototype and 3D Imaging Conference this May.
Erin Kutz wrote:
Some people feel guilty when evading their doctor’s recommendations; others need a logical reason to follow an instruction. Cambridge, MA-based Vitality tries to factor in these differences in motivations and psychological makeup to spur patients toward a common goal: to make sure they take their medications as prescribed.
On its most basic level, Vitality’s GlowCap system functions to remind users of when they’re forgetting their prescriptions. It involves an Internet-connected pill cap that also sends signals to a device that resembles a nightlight. When a deadline is missed, the system will blink and sound an alarm, which gets louder as time goes by. If the medication is still not taken, GlowCaps generate an automated phone call to the user to remind them to take a pill and ask them why they’ve forgotten it so far.
“We have a device that notices right in the moment that someone is making a decision and intervenes right away,” says founder and CEO David Rose, who previously founded and ran Ambient Devices, a Cambridge-based company that pioneered the use of household devices like clocks to convey information to people, on everything from the stock market to the weather.
The answers culled in these phone calls, in addition to initial interview questions with the user, help the Vitality system create a profile and determine the forces that motivate them, such as authority, social support, or rewards. Rose says there are many reasons beyond forgetfulness that users skip meds, such as concerns of cost, side effects, or lack of education on the effects of their disease. The GlowCaps system aims to both prevent those factors from becoming hindrances, and implement services that encourage users to take their drugs in the future, based on their individual psychological profiles.
For example, if the co-pay costs of a prescription cause a patient to skip meds, the system could help implement financial incentives for users who take their prescription when they’re supposed to. For patients motivated by authority figures, the system can help coordinate regular reports with their doctors, documenting their prescription adherence. GlowCaps helps coordinate refills with a patient’s pharmacy, too.
It also offers the capability to e-mail your adherence rate to a selected friend or family member, if you’re someone who is spurred by social support. Many patients taking medications to treat diseases that don’t cause immediate discomfort, such as high blood pressure, osteoporosis, or high cholesterol, are more inclined to skip pills. Vitality can target this user with regular, interactive, educational e-mails on the long-term effects of their disease.
“Just like an exquisite friend or boyfriend, we try to make a system that learns to adapt over time with what happens to work for you,” Rose says.
Wade wrote about the Vitality when the company’s Ethernet-connected device hit Amazon.com in August, selling for $99 each directly consumers, skewed toward baby boomers who need a way to keep their aging parents on track with taking medication. But Rose has since evolved his business to market and test-drive the product alongside bigger organizations. And Vitality has a new version of the GlowCap device, which uses a cellular network to connect to the Internet, and will be used in future distribution programs.
Later this month the company will …Next Page »
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The Point of Inquiry podcast has a great discussion with psychologist Scott Lilienfeld about his new book ’50 Great Myths of Popular Psychology’ and why scientific-sounding mental fairy tales persist, despite them having no good evidence to support them.
The most interesting bit is where Lilienfeld tackles why such myths have their psychological power, which to me is far the most interesting aspect of why certain stories perpetuate.
Some ideas seem to have properties that give them social currency. Here’s one of my favourite and you can try it out yourself – the usual format of the conversation goes something like this:
– Remember Bobby McFerrin, the ‘Don’t Worry Be Happy’ guy?
– Yeah, I remember him.
– Killed himself.
– Huh, that figures.
This myth has no evidence for it whatsoever, Bobby McFerrrin is alive and well, but it became so widespread that Snopes created a page debunking the story.
What is it about this story that makes it so easily accepted? Or perhaps, we should ask, what is it about this story which makes it so attractive to pass on to others?
There has been a considerable amount of research on the psychology of rumours that attempts to explain why we are motivated to spread them. A fantastic book called Rumor Psychology reviews the research which indicates that uncertainty, importance or outcome-relevant involvement, lack of control, anxiety, and belief are crucial – but this doesn’t seem to apply to all such rumours (as an aside, it’s interesting that these principles seem rarely applied in military PsyOps campaigns e.g. see PsyWar.org Iraq war leaflet archive).
On a personal level, you can see how these principles might apply to trite ‘women are from mars, women are from venus’ pop relationship psychology, but it doesn’t seem to apply quite so well to the commonly repeated myth that we use only 10% of our brains.
And when we consider the ‘Bobby McFerrin topped himself’ story, none of it seems relevant. Perhaps this is better thought of as ‘gossip’, but unfortunately the psychology of gossip is much less developed and relies largely on pseudo-evolutionary ideas about social bonding and the like (Robin Dunbar’s book Grooming, Gossip, and the Evolution of Language is perhaps the most developed example of this).
I often wonder if we need an experimental aesthetics of information that helps us understand why such stories are inherently attractive, in the same way that studies have begun to focus on what makes certain tunes catchy.
Link to Point of Inquiry podcast on PopPsy myths.
Filed under: Morning Scoop
Each morning, we dish out a few links we love.
Are these words damaging your eyesight? Here’s some important information on computer screens and eye damage, plus advice on how to avoid it.
When it comes to choosing friends, maybe you should take some advice from your husband — here’s why.
You know those proposed soda taxes? As it turns out, they’ll have to be pretttttty high if they’re going to make any sort of difference.
Addicted to washing your hands? Hygiene is important, but being too vigilant could be making you fat.
If you lose weight, what are you chances of regaining it? Some estimates say that 95 percent will gain it back — ouch!
Much has been made about the iPad as a consumptive, rather than creative, device. Some, including law professor Tim Wu at a recent New America event, have voiced concern that it heralds the end of a golden era of user-generated content. But to truly understand the importance and impact of user-generated content – including on the traditional media that Clay Shirky has recently argued are fatally too complex to survive – we must have better measurement of the phenomenon. Without reliable data and sensible comparative metrics, it is impossible to say if we have even experienced a golden age of open creative possibility.
For example, nearly two years ago in response to Shirky, Nick Carr bristled at the idea that the Web was the necessary component for creative production, participation and sharing. According to Carr, the people he knew back before the Web were also creating – writing, photographing, drawing, constructing and volunteering. This is undoubtedly true, but because technology did not enable the inexpensive recording, archiving, sharing and finding of this creativity, it went largely unnoticed. Of course, cheaper technology almost certainly does enable more creative production, but how much is hard to say.
When Shirky notes that an amateur video of two children has garnered more views than American Idol, Dancing with the Stars, and the Superbowl combined, it is comparing apples and oranges. A minute video hardly competes with the Superbowl for eyeballs; certainly the Internet has opened opportunities to competitors to the Superbowl, but let’s compare those. The problem is, we don’t currently have the categories and metrics necessary to make sense of the rise (and potential fall) of creation. Some people are trying to create quantify the impact of blogs on the news cycle, but in regards to other media types, we seem to be ignoring the problem and living off anecdotes. So, how can we move ahead with better metrics for user-generated content and what should those metrics be?
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Self-reliant bloggers everywhere should be getting pretty excited as WordPress 3.0 is coming very, very soon. For now, they can play with WordPress 3.0 Beta 1, released last week, which comes with most of the new and updated features slated for the big release, but it still has some rough edges in a few areas. The highlights include a new default theme, the WordPre… (read more)
Postal service in Finland, it seems, has had enough of sending postmen out in freezing temperatures and on long routes. In order to be more time and energy efficient, they will now open the letters, scan them and send them electronically to recipients. Currently, the program is in a trial mode and 126 households and 20 businesses are participating.
The message would be sent to a secure digital mailbox that can only be accessed by the original recipient. An email and mobile phone alert would also be sent informing the recipient about new mail. The exercise of opening and scanning the mail would take place in specially secured premises where the staff is bound by confidentiality obligations.
The program aims at reducing CO2 emissions and the number of employees used to distribute mail in the scattered population of one of the coldest countries in the world. The trial program starts on April 12th and will continue through the end of the year. However, despite all the claimed social, economical and environmental benefits, the program is being heavily debated by people who think that it would compromise the privacy. People are going as far as to suggest that this program will be used to spy on the confidential communication.
Do you think it will work in Finland or elsewhere in the world? Or is it too impractical due to privacy and other issues?
